Jakob Balslev Sørensen
Professor
Neuronal Signalling
Blegdamsvej 3
2200 København N.
- Published
A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells
Kedar, G. H., Munch, A. S., van Weering, J. R. T., Malsam, J., Scheutzow, A., de Wit, H., Houy, S., Tawfik, B., Söllner, T. H., Sørensen, Jakob Balslev & Verhage, M., 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 42, p. 14172-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex
Wiederhold, K., Kloepper, T. H., Walter, A. M., Stein, A., Kienle, N., Sørensen, Jakob Balslev & Fasshauer, D., 2010, In: Journal of Biological Chemistry. 285, 28, p. 21549-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A method of modelling time dependent data: swimming in guppies (Poecilia Reticulata) under threat of a predator
Bildsøe, M. & Sørensen, Jakob Balslev, Feb 1994, In: Behavioural Processes. 31, 1, p. 75-96 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A possible postsynaptic role for SNAP-25 in hippocampal synapses
Hussain, S., Ringsevjen, H., Schupps, M., Hvalby, Ø., Sørensen, Jakob Balslev, Jensen, V. & Davanger, S., 2019, In: Brain Structure and Function. 224, 2, p. 521-532Research output: Contribution to journal › Journal article › Research › peer-review
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A sequential vesicle pool model with a single release sensor and a ca(2+)-dependent priming catalyst effectively explains ca(2+)-dependent properties of neurosecretion
Walter, Alexander Matthias, da Silva Pinheiro, P. C., Verhage, M. & Sørensen, Jakob Balslev, Dec 2013, In: P L o S Computational Biology (Online). 9, 12, p. 1-15 15 p., e1003362.Research output: Contribution to journal › Journal article › Research › peer-review
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Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
Schotten, S., Meijer, M., Walter, Alexander Matthias, Huson, V., Mamer, L., Kalogreades, L., Ter Veer, M., Ruiter, M., Brose, N., Rosenmund, C., Sørensen, Jakob Balslev, Verhage, M. & Cornelisse, L. N., 2015, In: eLife. 4, p. 1-25 25 p., e05531.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric stabilization of calcium and lipid binding engages three synaptotagmins in fast exocytosis
Kobbersmed, J. R. L., Berns, M. M. M., Ditlevsen, Susanne, Sørensen, Jakob Balslev & Walter, Alexander Matthias, 23 Oct 2021, bioRxiv, p. 1-56.Research output: Working paper › Preprint › Research
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Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Kobbersmed, J. R. L., Berns, M. M. M., Ditlevsen, Susanne, Sørensen, Jakob Balslev & Walter, Alexander Matthias, 2022, In: eLife. 11, 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain
Nagy, G., Milosevic, I., Fasshauer, D., Müller, E. M., de Groot, B. L., Lang, T., Wilson, M. C. & Sørensen, Jakob Balslev, 2005, In: Molecular Biology of the Cell. 16, 12, p. 5675-85 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Electrostatic Energy Barrier for SNARE-Dependent Spontaneous and Evoked Synaptic Transmission
Ruiter, M., Kádková, Anna, Scheutzow, A., Malsam, J., Söllner, T. H. & Sørensen, Jakob Balslev, 2019, In: Cell Reports. 26, 9, p. 2340-2352, e1-e5Research output: Contribution to journal › Journal article › Research › peer-review
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An Improved Method for Growing Primary Neurons on Electron Microscopy Grids Co-Cultured with Astrocytes
Kumar, I., Paudyal, A., Kádková, Anna, Stewart, M., Sørensen, Jakob Balslev & Radecke, J., 2023, In: International Journal of Molecular Sciences. 24, 20, 15 p., 15191.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of the sodium recirculation theory of solute-coupled water transport in small intestine
Larsen, Erik Hviid, Sørensen, Jakob Balslev & Sørensen, J. N., 2002, In: Journal of Physiology. 542, Pt 1, p. 33-50 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C2-domain containing calcium sensors in neuroendocrine secretion
Pinheiro, P. S., Houy, S. & Sørensen, Jakob Balslev, Dec 2016, In: Journal of Neurochemistry. 139, 6, p. 943-958Research output: Contribution to journal › Review › Research › peer-review
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins
Jockusch, W. J., Speidel, D., Sigler, A., Sørensen, Jakob Balslev, Varoqueaux, F., Rhee, J. & Brose, N., 2007, In: Cell. 131, 4, p. 796-808 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comment on "Penetration of Action Potentials During Collision in the Median and Lateral Giant Axons of Invertebrates"
Berg, Rune W., Stauning, M. T., Sørensen, Jakob Balslev & Jahnsen, Henrik, 2017, In: Physical Review X. 7, 2, 3 p., 028001.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming
Cai, H., Reim, K., Varoqueaux, F., Tapechum, S., Hill, K., Sørensen, Jakob Balslev, Brose, N. & Chow, R. H., Dec 2008, In: PNAS Early Edition. 105, 49, p. 19538-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conflicting views on the membrane fusion machinery and the fusion pore
Sørensen, Jakob Balslev, 2009, In: Annual Review of Cell and Developmental Biology. 25, p. 513-37 24 p.Research output: Contribution to journal › Review › Research
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation
Nagy, G., Kim, J. H., Pang, Z. P., Matti, U., Rettig, J., Südhof, T. C. & Sørensen, Jakob Balslev, 2006, In: Journal of Neuroscience. 26, 2, p. 632-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differential abilities of SNAP-25 homologs to support neuronal function
Delgado-Martínez, I., Nehring, R. B. & Sørensen, Jakob Balslev, 2007, In: Journal of Neuroscience. 27, 35, p. 9380-91 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23
Sørensen, Jakob Balslev, Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C. & Neher, E., 2003, In: Cell. 114, 1, p. 75-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Dissecting docking and tethering of secretory vesicles at the target membrane
Toonen, R. F., Kochubey, O., de Wit, H., Gulyas-Kovacs, A., Konijnenburg, B., Sørensen, Jakob Balslev, Klingauf, J. & Verhage, M., 2006, In: EMBO Journal. 25, 16, p. 3725-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs
Houy, S., Groffen, A. J., Ziomkiewicz, I., Verhage, M., Pinheiro, P. S. & Sørensen, Jakob Balslev, 23 Dec 2017, In: eLife. 6, 29 p., e27000.Research output: Contribution to journal › Journal article › Research › peer-review
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Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release
da Silva Pinheiro, P. C., de Wit, H., Walter, Alexander Matthias, Groffen, A. J., Verhage, M. & Sørensen, Jakob Balslev, 16 Oct 2013, In: Journal of Neuroscience. 33, 42, p. 16459-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Gowrisankaran, S., Houy, S., del Castillo, J. G. P., Steubler, V., Gelker, M., Kroll, J., Pinheiro, P. S., Schwitters, D., Halbsgut, N., Pechstein, A., van Weering, J. R. T., Maritzen, T., Haucke, V., Raimundo, N., Sørensen, Jakob Balslev & Milosevic, I., 2020, In: Nature Communications. 11, 1, 1266.Research output: Contribution to journal › Journal article › Research › peer-review
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+
Sørensen, Jakob Balslev, Fernández-Chacón, R., Südhof, T. C. & Neher, E., 2003, In: Journal of General Physiology. 122, 3, p. 265-76 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extension of Helix 12 in Munc18-1 Induces Vesicle Priming
Munch, A. S., Kedar, G. H., van Weering, J. R. T., Vazquez-Sanchez, S., He, E., André, T., Braun, T., Söllner, T. H., Verhage, M. & Sørensen, Jakob Balslev, 29 Jun 2016, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36, 26, p. 6881-6891 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes
Mohrmann, R., de Wit, H., Verhage, M., Neher, E. & Sørensen, Jakob Balslev, 2010, In: Science.Research output: Contribution to journal › Journal article › Research › peer-review
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles
Sørensen, Jakob Balslev, 2004, In: Pflügers Archiv: European Journal of Physiology. 448, 4, p. 347-62 15 p.Research output: Contribution to journal › Review › Research
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Fusion Machinery: SNARE Protein Complex
Sørensen, Jakob Balslev & Milosevic, I., 2015, Presynaptic Terminals. Japan, p. 87-127 41 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
Maximov, A., Lao, Y., Li, H., Chen, X., Rizo, J., Sørensen, Jakob Balslev & Südhof, T. C., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 10, p. 3986-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
Man, K. M., Imig, Cordelia, Walter, A. M., da Silva Pinheiro, P. C., Stevens, D. R., Rettig, J., Sørensen, Jakob Balslev, Cooper, B. H., Brose, N. & Wojcik, S. M., 17 Nov 2015, In: eLife. 4, p. 1-28 28 p., e10635.Research output: Contribution to journal › Journal article › Research › peer-review
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Innervation by a GABAergic neuron depresses spontaneous release in glutamatergic neurons and unveils the clamping phenotype of synaptotagmin-1
Wierda, K. D. B. & Sørensen, Jakob Balslev, 5 Feb 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 6, p. 2100-10 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission
Schupp, M., Malsam, J., Ruiter, M., Scheutzow, A., Wierda, K. D. B., Söllner, T. H. & Sørensen, Jakob Balslev, 23 Nov 2016, In: Journal of Neuroscience. 36, 47, p. 11865-11880 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Introducing the special issue on “Proteins and Circuits in Memory”
Kjærgaard, M., Petersen, Nicolas Caesar, Sørensen, Jakob Balslev & Takeuchi, T., 2021, In: European Journal of Neuroscience. 54, 8, p. 6691-6695 5 p.Research output: Contribution to journal › Editorial › Research › peer-review
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MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in beta-sheet 10
Pons-Vizcarra, M., Kurps, J., Tawfik, B., Sørensen, Jakob Balslev, van Weering, J. R. T. & Verhage, M., 2019, In: Journal of Cell Science. 132, 23, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurements of Exocytosis by Capacitance Recordings and Calcium Uncaging in Mouse Adrenal Chromaffin Cells
Houy, S., Martins, J. S., Mohrmann, R. & Sørensen, Jakob Balslev, 2021, Methods in Molecular Biology. Niedergang, F., Vitale, N. & Gasman, S. (eds.). 1 ed. New Yorj: Humana Press, p. 233-251 19 p. (Methods in Molecular Biology, Vol. 2233).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability
Brito dos Santos, Altair, Larsen, Silas Dalum, Guo, L., Barbagallo, Paola, Montalant, A., Verhage, M., Sørensen, Jakob Balslev & Perrier, Jean-Francois Marie, 2023, In: Cell Reports Medicine. 4, 12, 19 p., 101308.Research output: Contribution to journal › Journal article › Research › peer-review
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Morphofunctional changes at the active zone during synaptic vesicle exocytosis
Radecke, J., Seeger, R., Kádková, Anna, Laugks, U., Khosrozadeh, A., Goldie, K. N., Lučić, V., Sørensen, Jakob Balslev & Zuber, B., 2023, In: EMBO Reports. 24, 5, 16 p., e55719.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
Walter, Alexander Matthias, Groffen, A. J., Sørensen, Jakob Balslev & Verhage, M., 2011, In: Trends in Neurosciences. 34, 9, p. 487-97 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells
Nili, U., de Wit, H., Gulyas-Kovacs, A., Toonen, R. F., Sørensen, Jakob Balslev, Verhage, M. & Ashery, U., 1 Dec 2006, In: Neuroscience. 143, 2, p. 487-500 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming
Gulyás-Kovács, A., de Wit, H., Milosevic, I., Kochubey, O., Toonen, R., Klingauf, J., Verhage, M. & Sørensen, Jakob Balslev, 2007, In: Journal of Neuroscience. 27, 32, p. 8676-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes
Zilly, F. E., Sørensen, Jakob Balslev, Jahn, R. & Lang, T., 2006, In: PLoS - Biology. 4, 10, p. e330Research output: Contribution to journal › Journal article › Research › peer-review
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Opposing functions of two sub-domains of the SNARE-complex in neurotransmission
Weber, J. P., Reim, K. & Sørensen, Jakob Balslev, 2010, In: EMBO Journal. 29, 15, p. 2477-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform
Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.Research output: Contribution to journal › Journal article › Research › peer-review
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Patch clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channels activated by cyclic AMP
Sørensen, Jakob Balslev & Larsen, Erik Hviid, Jul 1998, In: Journal of General Physiology. 112, 1, p. 19-31 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion
Houy, S., Silvestre Martins, Joana Andreia, Lipstein, N. & Sørensen, Jakob Balslev, 2022, In: eLife. 11, 26 p., e79433.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Walter, Alexander Matthias, Müller, R., Tawfik, B., Wierda, K. D., Pinheiro, P. S., Nadler, A., McCarthy, A. W., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Lehmann, M., Haucke, V., Hille, B., Schultz, C. & Sørensen, Jakob Balslev, 2017, In: eLife. 6, 41 p., e30203.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity
de Jong, A. P. H., Meijer, M., Saarloos, I., Cornelisse, L. N., Toonen, R. F. G., Sørensen, Jakob Balslev & Verhage, M., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 13, 8, p. 5095–5100 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells
Milosevic, I., Sørensen, Jakob Balslev, Lang, T., Krauss, M., Nagy, G., Haucke, V., Jahn, R. & Neher, E., 2005, In: Journal of Neuroscience. 25, 10, p. 2557-65 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing the Interaction Between Synaptotagmin-1 and SNARES using Mutations in SNAP-25
Schupp, M. & Sørensen, Jakob Balslev, 27 Jan 2015, In: Biophysical Journal. 108, 2, Supplement 1 , p. 102A-102A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
ID: 9847273
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Spatial distribution and temporal evolution of DRONPA-fused SNAP25 clusters in adrenal chromaffin cells
Research output: Contribution to journal › Journal article › Research › peer-review
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254
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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
249
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Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
Research output: Contribution to journal › Comment/debate › Research
Published