Kiehn Lab

We study the molecular, cellular, and network diversification of locomotor circuitries in mammals with the goal of providing a unified understanding of the functional organization of neuronal circuits that execute movements.

Ole Kiehn info
























































  • Zelenin PV, Vemula MG, Lyalka VF, Kiehn O, Talpalar AE, Deliagina TG.J Neurosci (2021) Apr. Differential Contribution of V0 Interneurons to Execution of Rhythmic and Nonrhythmic Motor Behaviors. J NEUROSCI 14;41(15):3432-3445. doi: 10.1523/JNEUROSCI.1979-20.2021. Epub 2021 Feb 26.PMID: 33637562

  • Wu H, Petitpré C, Fontanet P, Sharma A, Bellardita C, Quadros RM, Jannig PR, Wang Y, Heimel JA, Cheung KKY, Wanderoy S, Xuan Y, Meletis K, Ruas J, Gurumurthy CB, Kiehn O, Hadjab S, Lallemend F. Nat Commun. (2021) Feb. Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. Nature Communications. 15;12(1):1026. doi: 10.1038/s41467-021-21173-9. PMID: 33589589 Free PMC article.

  • Allodi I, Montañana-Rosell R, Selvan R, Löw P, Kiehn O (2021). Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons. Nature Communications. 12, Article number: 3251 (2021) >NatureComm


  • Yuste, R, Hawrylycz, M,...., Kiehn O,..., Lein, E (2020). A community-based transcriptomics classification and nomenclature of neocortical cell types. Nature Neuroscience. Aug 2413 s.  >NatureNeuro 
  • Cregg M J, Leiras R, Montalant A, Wanken P, Wickersham R I, Kiehn O (2020). Brainstem neurons that command mammalian locomotor asymmetries. Nature Neuroscience. May 11. DOI: s41593-020-0633-7 >NatureNeuro 
  • Marcantoni MFuchs ALöw PBartsch DKiehn OBellardita C (2020). Early delivery and prolonged treatment with nimodipine prevents the development of spasticity after spinal cord injury in mice. Science Translational Medicine. Apr 15. DOI: 10.1126/scitranslmed.aay0167 >Scitranslmed


  • Allodi I, Nijssen J, Benitez JA, Schweingruber C, Fuchs A, Bonvicini G, Cao M, Kiehn O, Hedlund E (2019). Modeling Motor Neuron Resilience in ALS Using Stem Cells. Stem Cell Reports >ScienceDirect
  • Wang Y, Wu H, Zelenin P, Fontanet P, Wanderoy S, Petitpré C, Comai G, Bellardita C, Xue-Franzén Y, Huettl RE, Huber AB, Tajbakhsh S, Kiehn O, Ernfors P, Deliagina TG, Lallemend F, Hadjab S (2019). Muscle-selective RUNX3 dependence of sensorimotor circuit development. Development. 2019 Oct 24;146(20). doi: 10.1242/dev.181750. >pubmed


  • Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T (2018). Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity. J Clin Invest Jun 12. doi: 10.1172/JCI120913 >pubmed
  • Häring M, Zeisel A, Hochgerner H, Rinwa P, Jakobsson J, Lönnerberg P, La Manno G, Sharma N, Borgius L, Kiehn O, Lagerström M, Linnarsson S, Ernfors P (2018). Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types. Nature Neuroscience Apr 23. >nature
  • Bellardita C, Marcantoni M, Löw P, Kiehn O (2018). Sacral Spinal Cord Transection and Isolated Sacral Cord Preparation to Study Chronic Spinal Cord Injury in Adult Mice. Bio Protocol Apr 05. >bio-protocol
  • Caggiano V, Leiras R, Goñi-Erro H, Masini D, Bellardita C, Bouvier J, Caldeira V, Fisone G, Kiehn O (2018). Midbrain circuits that set locomotor speed and gait selection. Nature Jan 17. doi: 10.1038/nature25448


  • Bellardita C, Caggiano V, Leiras R, Caldeira V, Fuchs A, Bouvier J, Löw P, Kiehn O (2017).Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice.Elife. Feb 13;6. pii: e23011>pubmed
  • Caldeira V, Dougherty KJ, Borgius L, Kiehn O (2016).Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.Sci Rep. 7: 41369.>pubmed


  • Kiehn O (2016).Decoding the organization of spinal circuits that control locomotion.Nat Rev Neurosci,17(4): 224-238.>pubmed


  • Bouvier J, Caggiano V, Leiras R, Caldeira V, Bellardita C, Balueva K, Fuchs A, Kiehn O (2015).Descending Command Neurons in the Brainstem that Halt Locomotion.Cell,163(5): 1191-1203.>pubmed
  • Kiehn O, Churchland MM (2015).Editorial overview: Motor circuits and action.Curr Opin Neurobiol,33(Aug): v-vi.>pubmed
  • Bellardita C, Kiehn O (2015).Phenotypic characterization of speed-associated gait changes in mice reveals modular organization of locomotor networks.Curr Biol,25(11): 1426-1436.>pubmed
  • Ruffault PL, D'Autréaux F, Hayes JA, Nomaksteinsky M, Autran S, Fujiyama T, Hoshino M, Hägglund M, Kiehn O, Brunet JF, Fortin G, Goridis C (2015).The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2.Elife,4: 10.7554/eLife.07051.>pubmed
  • Shevtsova NA, Talpalar AE, Markin SN, Harris-Warrick RM, Kiehn O, Rybak IA (2015).Organization of left-right coordination of neuronal activity in the mammalian spinal cord: Insights from computational modelling.J Physiol,593(11): 2403-2426.>pubmed


  • Zhang MD, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G,Kiehn O, Watanabe M, Uhlén M, Mulder J, Deisseroth K, Harkany T, Hökfelt TG (2014).Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.Proc Natl Acad Sci U S A,111(12): E1149-1158.>pubmed
  • Borgius L, Nishimaru H, Caldeira V, Kunugise Y, Löw P, Reig R, Itohara S, Iwasato T, Kiehn O (2014).Spinal Glutamatergic Neurons Defined by EphA4 Signaling Are Essential Components of Normal Locomotor Circuits.J Neurosci,34(11): 3841-3853.>pubmed
  • Forssberg H, Kiehn O (2014).[2014 Nobel Prize in Physiology or Medicine. The Nobel laureates have explored the internal GPS of the brain].(Article in Swedish).Läkartidningen,111(41): 1766-1767.>pubmed


  • Dougherty KJ, Zagoraiou Z, Satoh D, Rozani I, Doobar S, Arber S, Jessell TM, Kiehn O. (2013).Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons.Neuron,80(4): 920-933.>pubmed
  • Rybak IA, Shevtsova NA, Kiehn O. (2013).Modelling genetic reorganizations in the mouse spinal cord affecting left-right coordination during locomotion.J Physiol.591(Pt 22):5491-5508>pubmed
  • Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O (2013).Dual-mode operation of neuronal networks involved in left–right alternation.Nature, 500: 85–88.>pubmed
  • Hägglund M, Dougherty KJ, Borgius L, Itohara S, Iwasato T, Kiehn O (2013).Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion.Proc Natl Acad Sci U S A.110(28):11589-94. >pubmed


  • Talpalar AE, Endo T, Löw P, Borgius L, Hägglund M, Dougherty KJ, Rygg J, Hnasko TS, Kiehn O (2011).Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord.Neuron, 71(6):1071-84.>pubmed
  • Leão RN, Colom LV, Borgius L, Kiehn O, Fisahn A (2011).Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons.Neurobiol Aging.2012 Sep;33(9):2046-61.>pubmed
  • Restrepo CE, Margaryan G, Borgius L, Lundfald L, Sargsyan D, Kiehn O (2011).Change in the balance of excitatory and inhibitory midline fiber crossing as an explanation for the hopping phenotype in EphA4 knockout mice.European Journal of Neuroscience, 34(7):1102-12.>pubmed
  • Kiehn, O (2011).Development and functional organization of spinal locomotor circuits.Current Opinion of Neurobiology, 21(1):100-9>pubmed


  • Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, Stoeckli ET, Kiehn O, Arnold HH. (2010).The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance.Development, 137(24): 4249-60.>pubmed
  • Kiehn O, Dougherty KJ, Hägglund M, Borgius L, Talpalar A, Restrepo CE. (2010)Probing spinal circuits controlling walking in mammals.Biochemical and Biophysical Research Communication, Karolinska Institutet 200 year anniversary, special issue 396(1): 11-18. >pubmed
  • Ryge J, Winther O, Wienecke J, Sandelin A, Westerdahl AC, Hultborn H, Kiehn O. (2010).Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury.BMC Genomics. 11: 365-387.>pubmed
  • Borgius L, Restrepo CE, Leao RN, Saleh N, Kiehn O. (2010).A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons.Molecular and Cellular Neuroscience, 45(3):245-257.>pubmed
  • Talpalar AE, Kiehn O. (2010)Glutamatergic mechanisms for speed control and networkoperation in the rodent locomotor CPG.Frontiers in Neuroscience: Neural Circuits, (4) pii: 1-14.>pubmed
  • Hägglund M, Borgius L, Dougherty KJ, Kiehn O. (2010).Activation of glutamatergic neurons in the mammalian brainstem or spinal cord evoke hind-limp locomotion.Nature Neuroscience, 13(2): 246-52.>pubmed
  • Dougherty KJ, Kiehn O. (2010).Functional organization of V2a-related locomotor circuits in the rodent spinal cord.Ann N Y Acad Sci, 1198:85-93.>pubmed
  • Dougherty KJ, Kiehn O. (2010).Firing and cellular properties of V2a interneurons in the rodent spinal cord.Journal of Neuroscience, 30(1): 24-37.>pubmed
  • Wienecke J, Westerdahl A-C, Hultborn H, Kiehn O. Ryge J, (2010).Global gene expression analysis of rodent motor neurons following spinal cord transaction associate molecular mechanisms to the development of post-injury spasticity.Journal of Neurophysiology, 103(2): 761-78.>pubmed


  • Restrepo, E, Lundfald, Szabó, LG F. Erdélyi, F, H.U. Zeilhofer, HU, Glover JC, Kiehn O (2009).Transmitter phenotype of commissural interneurons in the rodent spinal cord.Journal of Comparative Neurology, 517 (2): 177-193.>pubmed


  • Endo T, and Kiehn O. (2008).Asymmetric operation of the locomotor central pattern generator in the neonatal mouse spinal cord.Journal of Neurophysiology,100(6): 3043-3054.>pubmed
  • Ryge J, Westerdahl AC, Alstrøm P, and Kiehn O. (2008).Gene expression profiling of two distinct neuronal populations in the rodent spinal cord.PLoS ONE, 3(10): e3415-25.>pubmed
  • Crone, S, Quinlan, KA, Zagoraiou, L, Droho, S, Restrepo, CE, Lundfald, L Setlak J, Jessell TM, Kiehn# O and Sharma, K# (2008).Selective ablation of ipsilateral excitatory interneurons decouples left-right locomotor coordination.Neuron, 60(1): 70-83. # shared last author.>pubmed
  • Kiehn O, Quinlan KA, Restrepo CE, Lundfald L, Borgius L, Talpalar AE, Endo T. (2008).Excitatory components of the mammalian locomotor CPG.Brain Research Review, 57(1): 56-63.>pubmed


  • Lundfald L, Restrepo CE, Butt SJ, Peng CY, Droho S, Endo T, Zeilhofer HU, Sharma K, Kiehn O (2007).Phenotype of V2-derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord. European Journal of Neuroscience. 26(11): 2989-3002.>pubmed
  • Quinlan KA, Kiehn O. (2007).Segmental, synaptic actions of commissural interneurons in the mouse spinal cord.Journal of Neuroscience, 27(24): 6521-30.>pubmed
  • Wallen, P., Grillner S., and Kiehn, O. (2007). Nätverk styr våra rörelser.Pp 75-90. Hjärnan (ed. Olson, L). Karolinska Institutet, University Press.


  • Kiehn O (2006).Locomotor circuits in the mammalian spinal cord.Annual Review in Neuroscience, 29: 279-306.>pubmed
  • Nishimaru, H, Restrepo CE, Kiehn, O. (2006).Activity of Renshaw cells during locomotor-like rhythmic activity in the isolated spinal cord of neonatal mice.Journal of Neuroscience, 26(20): 5320-8.>pubmed
  • Gosgnach S, Lanuza GM, Butt SJB, Saueressig H, Ying Zhang Y, Velasquez T, Callaway E, Kiehn O, Goulding M (2006).V1 spinal neurons regulate the speed of vertebrate locomotor outputs.Nature, 440(7081): 215-9.>pubmed


  • Butt SJB, Lundfald L, Kiehn O (2005)EphA4 defines a class of excitatory locomotor-related interneurons.PNAS,102(39): 14098-103. >pubmed
  • Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R. (2005).Regulation of EphA4 Kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function.Neuron, 47(4): 515-528.>pubmed
  • Lee IH, Lindqvist E, Kiehn O, Widenfalk J, Olson L. (2005)Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury.Journal of Comparative Neurology, 489(1): 1-10.>pubmed
  • Nishimaru H, Restrepo CE, Ryge J, Yanagawa Y, Kiehn O (2005)Mammalian motor neurons corelease glutamate and acetylcholine at central synapses.PNAS, 102(14): 5245-5249.>pubmed


  • Kiehn O, Kullander K. (2004).Central pattern generators deciphered by molecular genetics.Neuron,41(3): 317-21.>pubmed


  • Butt S.J.B., Kiehn O. (2003).Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals.Neuron,38(6): 953-63.>pubmed
  • Birinyi A., Viszokay K., Weber I, Kiehn O., Antal, M (2003).Synaptic targets of commissural interneurons in the lumbar spinal cord of neonatal rats.Journal of Comparative Neurology, 467: 429-40.>pubmed
  • Kiehn O, Butt SJ. (2003).Physiological, anatomical and genetic identification of CPG neurons in the developing mammalian spinal cord.Progress in Neurobiology,70(4): 347-61.>pubmed
  • Kullander K. , Butt S.J.B., Lebret J., Lundfald L., Restrepo E., Klein R., Kiehn, O. (2003).Role of EphA4 and EphrinB3 in local circuits that control walking.Science, 299: 1889-1892.>pubmed
  • Merrywest, S., McDearmid J., Kjaerulff O., Kiehn O., Sillar, KT. (2003).Mechanisms underlying the noradrenergic modulation of longitudinal co-ordination during swimming in Xenopus lavevis tadpoles.European Journal of Neuroscience, 17:1013-1022.>pubmed


  • Butt SJB, Lebret J, Kiehn O. (2002).Organization of left right alternation in the mammalian locomotor network.Brain Research Review, 40 (1-3): 107-117.>pubmed
  • Kiehn, O. and Tresch, MC (2002).Gap junctions and motor behavior. Trends in Neuroscience,25(2): 108-115.>pubmed
  • Butt SJ, Harris-Warrick RM, Kiehn O. (2002).Firing properties of identified interneuron populations in the mammalian hindlimb central pattern generator.Journal of Neuroscience, 22(22): 9961-9971.>pubmed
  • Tresch MC, Kiehn O. (2002).Synchronization of motor neurons during locomotion in the neonatal rat: predictors and mechanisms.Journal of Neuroscience, 22(22): 9997-10008.>pubmed
  • Stokke MF, Nissen UV, Glover JC., Kiehn O. (2002).Projection patterns of commissural interneurons in the lumbar spinal cord of the neonatal rat.Journal Comparative Neurology, 446(4): 349-359.>pubmed


  • Beierholm U, Nielsen CD, Ryge J, Alstrom P, Kiehn O. (2001).Characterization of reliability of spike timing in spinal interneurons during oscillating inputs.Journal of Neurophysiology, 86(4): 1858-1868.>pubmed
  • Kjaerulff O, Kiehn O. (2001).5-HT modulation of multiple inward rectifiers in motoneurons in intact preparations of the neonatal rat spinal cord.Journal of Neurophysiology, 85(2): 580-593.>pubmed


  • Tresch MC, and Kiehn O. (2000). Population reconstruction of the locomotor cycle from interneuron activity in the mammalian spinal cord.Journal Neurophysiology, 83(4): 1972-1978.>pubmed
  • Gorassini M, Eken T, Bennett DJ, Kiehn O, and Hultborn H. (2000).Activity of hindlimb motor units during locomotion in the conscious rat.Journal of Neurophysiology, 83(4): 2002-2011.>pubmed
  • Raastad M, and Kiehn O. (2000).Spike coding during locomotor network activity in ventrally located neurons in the isolated spinal cord from neonatal rat.Journal of Neurophysiology, 83(5): 2825-2834.>pubmed
  • Tresch MC, and Kiehn O. (2000).Motor coordination without action potentials in the mammalian spinal cord.Nature Neuroscience, 3(6): 593-599.>pubmed
  • Kiehn O, Kjaerulff O, Tresch MC, and Harris-Warrick RM. (2000).Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord.Brain Research Bulletin, 53(5): 649-659.>pubmed


  • Gorassini M, Bennett DJ, Kiehn O, Eken T, and Hultborn H. (1999)Activation patterns of hindlimb motor units in the awake rat and their relation to motoneuron intrinsic properties.Journal of Neurophysiology, 82(2): 709-717.>pubmed
  • Kiehn O, Sillar KT, Kjaerulff O, and McDearmid JR. (1999).Effects of noradrenaline on locomotor rhythm-generating networks in the isolated neonatal rat spinal cord.Journal of Neurophysiology, 82(2): 741-746.>pubmed
  • Tresch MC, and Kiehn O. (1999).Coding of locomotor phase in populations of neurons in rostral and caudal segments of the neonatal rat lumbar spinal cord.Journal of Neurophysiology, 82(6): 3563-3574.>pubmed
  • Eide AL, Glover J, Kjaerulff O, and Kiehn O. (1999).Characterization of commissural interneurons in the lumbar region of the neonatal rat spinal cord.Journal of Comparative Neurology,403(3): 332-345.>pubmed


  • Kiehn O, and Eken T. (1998).Functional role of plateau potentials in vertebrate motor neurons.Current Opinion Neurobiology, (6): 746-52.>pubmed
  • Kiehn O, and Kjaerulff O. (1998)Distribution of central pattern generators for rhythmic motor outputs in the spinal cord of limbed vertebrates.Ann N Y Acad Sci. 860:110-129.>pubmed
  • Raastad M, Enríquez-Denton M, and Kiehn O. (1998).Synaptic signaling in an active central network only moderately changes passive membrane properties.PNAS, 95(17): 10251-6.>pubmed


  • Kjaerulff, O. and Kiehn, O. (1997).Crossed synaptic inpus to motoneurons during selective activation of the contralateral locomotor network.Journal of Neuroscience, 17(24): 9433-9447.>pubmed
  • Kiehn, O. and Eken, T. (1997).Prolonged firing in motor units - evidence of plateau potentials in human motoneurons?Journal of Neurophysiology, 78(6): 3061-3068.>pubmed
  • Booth, V. Rinzel, J. and Kiehn, O. (1997).A compartmental model of vertebrate motoneurons for Ca2+-dependent spiking and plateau potentials under pharmacological treatment.Journal of Neurophysiology, 78(6): 3371-3385.>pubmed
  • Raastad, M., Johnson, B.R. and Kiehn O. (1997).An analysis of excitatory and inhibitory postsynaptic currents carrying information about rhythmic activity in the isolated spinal cord from neonatal rats.Journal of Neurophysiology, 78(4): 1851-1859.>pubmed
  • Iizuka, M., Kiehn, O. and Kudo, N. (1997).Development of sensory resetting of 5-HT and NMDA-induced locomotion in neonatal rats.Experimental Brain Research,114. 193-204.>pubmed


  • Raastad, M. Johnson, B.R. and Kiehn O. (1996).The number of single postsynaptic currents necessary to produce locomotor-related cyclic information in neurons in the neonatal rat spinal cord.Neuron, 729-738.>pubmed
  • Kiehn, O., Johnson, B.R. and Raastad, M. (1996).Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity.Neuroscience, 75 (1): 263-273.>pubmed
  • Kjærulff, O. and Kiehn, O. (1996).Distribution of Networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro. A lesion study.Journal of Neuroscience,16(8): 5777-5794.>pubmed
  • Kiehn, O. and Kjærulff, O. (1996).Spatiotemporal characteristics of 5-HT and dopamine-induced hindlimb locomotor activity in the in vitro neonatal rat.Journal of Neurophysiology, 75(4): 1472-1482.>pubmed
  • Kiehn, O., Erdal, J. Eken, T. and Bruhn, T. (1996).Selective depletion of spinal monoamines changes the rat soleus EMG from a tonic to a more phasic pattern.Journal of Physiology, 492 (1): 173-184.>pubmed


  • Kjærulff, O., Barajon, I. and Kiehn, O. (1994).Distribution of sulforhodamine labelled cells in the neonatal rat spinal cord following chemically induced locomotor activity in vitro.Journal of Physiology, 478 (2): 265-273.>pubmed


  • Nielsen, J., Petersen, N., Ballegaard, M., Biering-Sørensen, F. and Kiehn, O. (1993).H-reflexes are less depressed following muscle stretch in spastic spinal cord injured patients than in healthy subjects.Experimental Brain Research,97: 173-176.>pubmed
  • Hounsgaard, J. and Kiehn, O. (1993).Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro.Journal of Physiology, 468: 245-259.>pubmed


  • Hultborn, H. and Kiehn, O. (1992).Neuromodulation of vertebrate motoneurone membrane properties. Current Opinion in Neurobiology, 2: 770-775.>pubmed
  • Kiehn, O., Iizuka, M. and Kudo, N. (1992).Resetting from low threshold afferents of N-methyl-D-aspartate-induced locomotor rhythm in the isolated spinal cord-hindlimb preparation newborn rats.Neuroscience Letters, 148: 43-46.>pubmed
  • Kiehn, O. and Hultborn, H. and Conway, B. (1992).Rhythmic spinal locomotor activity in acutely spinalized cats induced by intrathecal application of noradrenaline.Neuroscience Letters, 143: 243-246.>pubmed
  • Kiehn, O., Rostrup, E and Møller, M. (1992).Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyroxin hydroxylase.Journal of Comparative Neurology, 325(4): 527-547.>pubmed
  • Kiehn, O. and Harris-Warrick, R. (1992).5-HT modulation of hyperpolarization-activated current and calcium-dependent outward current in a Crustacean motoneurone.Journal of Neurophysiology, 68 (2): 496-508.>pubmed
  • Kiehn, O. and Harris-Warrick, R. (1992).Serotonergic stretch receptors induce plateau properties in a Crustacean motoneurone by a dual conductance mechanism. Journal of Neurophysiology, 68 (2): 485- 495.>pubmed


  • Kiehn, O. (1991).Plateau potentials and active integration in the 'final common pathway' for motor behaviour.Trends in Neurosciences, 14 (2): 68-73.>pubmed


  • Hounsgaard, J. and Kiehn, O. (1989).Serotonin induced bistability of turtle motoneurones caused by a nifedipine sensitive plateau potential.Journal of Physiology 414: 265-282.>pubmed
  • Eken, T., Hultborn, H. and Kiehn, O. (1989). Possible function of transmitter-controlled plateau potentials in alfa-motoneurones.Progress in Brain Research, 257-267.>pubmed
  • Eken, T. and Kiehn, O. (1989).Bistable firing properties of soleus motor units in freely moving rats.Acta Physiologica Scandinavica, 136 (3): 383-394.>pubmed


  • Conway, B.A., Hultborn, H., Kiehn, O. and Mintz, I. (1988).Plateau potentials in alpfa-motoneurones induced by intravenous injection of DOPA and clonidine in the spinal cat.Journal of Physiology, 405: 369-384.>pubmed
  • Hounsgaard, J., Hultborn, H., Jespersen, B. and Kiehn, O. (1988).Bistability of alpfa-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan.Journal of Physiology, 405: 345-367.>pubmed
  • Crone, C., Hultborn, H., Kiehn, O., Mazieres, L. and Wigström, H. (1988).Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat.Journal of Physiology 405: 321-343.>pubmed
  • Hounsgaard, J., Kiehn, O. and Mintz, I. (1988).Response properties of motoneurones in a slice preparation of the turtle spinal cord.Journal of Physiology, 398: 575-589.>pubmed


  • Conway, B.A., Hultborn, H. and Kiehn, O. (1987).Proprioceptive input resets central locomotor rhythm in the spinal cat.Experimental Brain Research, 68: 643-656.>pubmed


  • Hounsgaard, J., Hultborn, H. and Kiehn, O. (1986).Transmitter-controlled properties of alfa-motoneurones causing a long-lasting motor discharge to brief excitatory inputs.Progress in Brain Research, 64: 39-49.>pubmed


  • Hounsgaard, J. and Kiehn, O. (1985).Ca++ dependent bistability by serotonin in spinal motoneurones.Experimental Brain Research, 57: 422-425.>pubmed


  • Hounsgaard, J., Hultborn, H., Jespersen, B. and Kiehn, O. (1984).Intrinsic membrane properties causing a bistable behaviour of alpfa-motoneurones.Experimental Brain Research, 55: 391-394.>pubmed


  • Hansen T, Kiehn O, Kristensen J, Larsen JE, Lorenzen T, Pociot F, Rathcke M, Norn M. (1983).Schirmer’s tåretest.Ugeskr Laeger. 145(34): 2573-5.>pubmed

Guest Editor

  • Brains Research Reviews (2008) – Special issue Vol 57(1):Networks in Motion.Editors Grillner S, El Manira A, Kiehn O, Rossignol S, Stein P.
  • Current Opinions of Neurobiology (2002),Motor Section. Editors: Anderson and Kiehn.
  • Brains Research Reviews (2002) – Special issue Vol. 40 (1-3). Editors: Schouenborg J., Kiehn O., Garwic M., Grillner S., Hultborn H.
  • Kiehn, O. and Midtgaard, J. (1996).Transmission and processing of synaptic information in single cells.Acta Physiologica Scandinavica 157(3), 367-368.
  • Annals of the New York Academy of Sciences (1998).Neuronal Mechanisms for Generating Locomotor Activity. Editors Kiehn O, Harris-Warrick RM, Jordan LM, Hultborn H, Kudo N.>link

Book chapters

  • Ole Kiehn O, Dougherty K (2013).Locomotion: Circuits and Physiology.In: Neuroscience in the 21st Century (D.W. Pfaff ed.), chapter 38. Published by Springer Science+Business Media.
  • Kiehn, O (2010).Locomotor Circuits in the Developing Rodent Spinal Cord.In: Brain Microcircuits (Shepherd, G.M. and Grillner, S., eds.), chapter 37. Published by Oxford University Press.
  • Kiehn, O (2008).Rhythmic Movements.Field review. "Encyclopedia of Neuroscience", Springer, Germany.>link
  • Kiehn O. et al (2006).Microcircuits in motor systems.77-105- In "Microcircuits: The interface between neurons and global brain function" (eds. Grillner et al.). Status report from Dahlem Conference 2005 – Kiehn Rapporteur. MIT press.
  • Kiehn, O. and Katz, P.S (1998).Making Circuits Dance: Modulation of Motor Pattern Generation.In "Neuromodulation" (ed. Katz, P.S), chapter 7. Published by Oxford University Press.
  • Kiehn, O., Hounsgaard, J. and Sillar, K.T. (1997).Basic buildings blocks of vertebrate central pattern generators.In: Neurons, Networks and Motor Behavior (Stein, P.S.G., Grillner, S., Selverston, A. and Stuart, D.G., eds.), chapter 9, pp. 47-59 MIT Press, Cambrige, USA.
  • Sillar, K.T., Kiehn, O. and Kudo, N. (1997).Chemical modulation of vertebrate motor circuits.In: Neurons, Networks and Motor Behavior (Stein, P.S.G., Grillner, S., Selverston, A. and Stuart, D.G., eds.), chapter 19, pp. 183-193. MIT Press, Cambrige, USA.
  • Kiehn, O. and Kjærulff, O. (1995).Organization of spinal locomotor networks and their afferent control in the neonatal rat.In Neural Control of Movements, (Ferrel W.B and Proske, U. eds.), Plenum Publishing, pp. 179-187.
  • Kiehn, O. (1993).Transmitter-modulation and possible function of plateau properties in mammalian motoneurones.Physiological Society Magazine (London) 8, 35-38.
  • Harris-Warrick, R.M., Flamm, R.E., Johnson, B.R., Katz, P.S., Kiehn, O. and Zhang, B. (1992).Neuromodulation of the small networks in Crustacean.In Proceedings of Neurotox '91, (Duce, I.R. ed), pp. 305-321. Elsevier Science Publishers, Amsterdam.
  • Kiehn, O. (1991).Electrophysiology of 5-HT on vertebrate motoneurones.In: Aspects of Synaptic Transmission vol 1: LTP, Galanin, Opiods, Autonomic and 5-HT ed. T. Stone, chapter 18, pp. 527-555. Taylor, London.
  • >link

Doctoral Thesis

  • Kiehn, O. (1990).Monoaminergic regulation of plateau potentials in vertebrate spinal motoneurones - basic mechanisms and possible functional role.Eget forlag, 1-40.

General papers about Neurobiology

  • Wallen, P., Grillner S., andKiehn, O.(2007).Nätverk styr våra rörelser.Pp 75-90. Hjärnan (ed. Olson, L). Karolinska Institutet, University Press.
  • Kiehn, O.(1996).Funktionelle studier af rygmarvens gangnetværk under udvikling.Novos årsskrift 1995, 8-11.
  • Kiehn, O. (1994).GÅ IND I HJERNEN.WeekendAvisens forskningsside 25-29 marts, 20.
  • Jahnsen, H. andKiehn, O. (1989).Nysyn på hjernen.Naturkampen 51, 9-13.



Lab members

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Carmelo Bellardita Assistant Professor Kiehn lab Billede af Carmelo Bellardita
Debora Masini Postdoc Kiehn Lab Billede af Debora Masini
Haizea Goñi Erro Research Assistant Kiehn lab Billede af Haizea Goñi Erro
Ilary Allodi Assistant Professor Allodi lab Billede af Ilary Allodi
Ima Mustafic Senior Global Mobility Consultant Kiehn Lab Billede af Ima Mustafic
Irene Lisa Vargas Industrial PhD Kiehn Lab Billede af Irene Lisa Vargas
Iryna Vesth-Hansen Laboratory Technician Kiehn lab Billede af Iryna Vesth-Hansen
Jan Mikolaj Kaminski Academic Research Staff Kiehn Lab Billede af Jan Mikolaj Kaminski
Jared Cregg Assistant Professor Kiehn lab Billede af Jared Cregg
Li-Ju Hsu Postdoc Kiehn lab Billede af Li-Ju Hsu
Micael Lønstrup Laboratory Technician. Lauritzen Lab, Kiehn Lab, Cai Lab Billede af Micael Lønstrup
Michael Aagaard Andersen Postdoc Kiehn lab Billede af Michael Aagaard Andersen
Nathalie Krauth Postdoc Kiehn Lab Billede af Nathalie Krauth
Ole Kiehn Professor Kiehn lab Billede af Ole Kiehn
Raghavendra Selvan Assistant Professor Kiehn Lab Billede af Raghavendra Selvan
Rasmus von Huth Friis Master-Student Kiehn Lab Billede af Rasmus von Huth Friis
Roberto Leiras Gonzalez Assistant Professor Kiehn lab Billede af Roberto Leiras Gonzalez
Roser Montañana-Rosell PhD Student Kiehn Lab, Allodi Lab Billede af Roser Montañana-Rosell
Simrandeep Kaur Sidhu Master-Student Kiehn Lab Billede af Simrandeep Kaur Sidhu