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Scientists who wish to establish a research group hosted by the Department and financed by a group leader research grant covering the applicant’s own salary (Lundbeck Foundation Fellowships, Independent Research Fund Denmark’s Sapere Aude program, ERC Starting grants, Novo Foundation Hallas Møller grants etc.) will need the support by one of the group leaders in the department and by the Head of Department. The Head of Department will forward the CV and application outline to the leadership team to obtain comments. The Head of Department might seek input from additional group leaders, or scientists outside the Department. To allow enough time to establish the suitability for the Department, the applicant must approach the Head of Department at least one month prior to the application deadline with both a CV and a draft application. It is the Department’s experience that having a mentor within the Department increases the success rate - this is especially true for foreign applicants. Therefore, applicants are encouraged to seek the active mentorship of existing group leaders early in the process.

To receive the endorsement of the Department, the applicant needs to demonstrate all of the following points:

1. a strong application that has a good chance of getting funded (include information about mentorships),
2. a strong interest in joining the department on those terms which follow from the application itself (this might be established by signing a ‘letter of intent’, or similar); it is understood that the Department’s abilities to further support the applicant as part of a post-award negotiation are currently very limited,
3. a strong synergy with the Department in terms of research and teaching.

Support for applications may be declined by the Head of Department if

1. the above terms are not convincingly established (for instance if the application is deemed unlikely to succeed),
2. the applicant’s research or teaching profile does not fit the Departmental strategy,
3. affiliation of the applicant will require resources (space/equipment), which are not available in the Department, and for which there is no funding,
4. the Head of Department decides to prioritize other competing applications.

Neurons transport many proteins from the cell body to the axon terminals, sometimes across a distance of more than 1 meter, to maintain the presynaptic machinery that underlies neurotransmitter recycling and release. This fascinating process is called axonal transport. To provide energy, mitochondria are also transported to the release sites. Other organelles such as lysosomes also undergo axonal transport, which is vital for clearing the axon for worn-out and potentially toxic components. Disturbed axonal transport is linked to neurodegeneration such as Alzheimer's disease and peripheral neuropathy.

If you are interested in studying how axonal transport is accomplished and regulated using advanced genetic and cell biological methods, please contact Ole Kjaerulff.

In the Lauritzen lab we work on a range of projects all related to the brain physiology and blood vasculature. Our focus is how the brain is kept healthy with aging and in disease. We have many years of experience in in vivo physiology in mice using basic electrophysiological and laser-optic techniques, transgenic mice, and 2-photon microscopy. If you have some time to invest you can get experience with microsurgery and live imaging of brain cells and vessels through cranial windows.

If this might interest you please contact Barbara Lykke Lind or Martin Lauritzen 

Are you interested in knowing how neurotransmitters are released by vesicular exocytosis within one millisecond of the arrival of an action potential? Are you interested in using patch-clamp and advanced fluorescence techniques to study neurotransmitter release in real time? Do you want to know how this machine is working – and how it is regulated, for instance during learning? Do you want to know how mutation or other insults to the release machinery lead to diseases such as epilepsy, schizophrenia or intellectual disability? Do you want to come up with ideas how to counteract such mutations/insults, and find new ways to treat disease?

If one or more of these questions sound interesting to you please contact Jakob B. Sørensen

Are you interested in molecular and cellular neurobiology? Do you want to understand how neurons control activity and availability of neurotransmitter receptors and transporters in the synapse? Are you interested in understanding how mutations in these proteins contribute to CNS-diseases such as depression, ADHD, Parkinson’s disease, schizophrenia and addiction? Do you want to know how you become addicted to drugs such as cocaine or amphetamine?

If one or more of these questions sound interesting to you please contact Ulrik Gether

Would you like to know how membrane proteins like neurotransmitter transporters work at the molecular level? Are you interested in using crystallography and advanced fluorescence techniques to study their transport function? Do you want to characterize how drugs act on neurotransmitter transporters? Are you interested in finding new ways to discover drugs for treatment of e.g. cocaine addiction and depression?

If one or more of these questions sound interesting to you please contact Claus Juul Løland or Ulrik Gether

Are you interested in how neuronal scaffolding proteins regulate synaptic signaling processes? Would you like to know if scaffolding proteins could be a new target for treatment of CNS-diseases such as stroke and addiction? Would you like to understand the role of membrane-shaping protein domains (e.g. BAR domains) in neuronal scaffolding? Do you want to know how BAR domain proteins control protein trafficking not only in neurons but also in other cells such as endocrine cells?

If one or more of these questions sound interesting to you please contact Kenneth L. Madsen or Ulrik Gether