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Join the Department of Neuroscience

The Department of Neuroscience offers excellent opportunities for highly motivated and talented master students, PhD students and postdocs to participate in neuroscience research.

Please take time to look through the descriptions of our research groups to find the area of research that best correlates with your scientific interest and background.

You are welcome to send an unsolicited application including a letter of interest, CV and letter of references directly to one of our research group leaders.

 

 

 

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Student opportunities

We invite highly motivated, dedicated and skilled students to contact us for an interview. We have long-term experience with supervision of bachelor and Master’s students with different backgrounds (human biology, medicine, molecular biomedicine, biology, biochemistry). Competent and committed supervision has our highest priority and projects are designed to full-fill the criteria of the individual study.

We value scientific excellence, creativity, knowledge sharing, helpfulness and dedication in our laboratories. We offer a dynamic and international research environment involving a large network of collaborators around the world.

Bachelor and Master’s projects are available in the following areas:

 

 

 

 

 

 

 

 

 

 

 

 

 

Master’s project in Neuroscience

We are offering Master’s thesis project in neuronal calcium imaging and electrophysiology to study the role of interneurons in an animal model of schizophrenia.

The project will start in September or as soon as possible hereafter. We are looking for a candidate with a Master’s project duration of 12-18 months.

Project description

Parvalbumin-positive (PV+) interneurons comprise a third of total inhibitory neuron population in the cortex and were shown to be the key subtype of interneurons that control information flow. PV+ interneurons regulate synchronization of oscillations (i.e. rhythmic brain activity) in the brain by controlling output of principal neurons and thus modulate cortical network activity. PV+ interneurons are affected in schizophrenia disorders. However, there are >10 subtypes of PV+ interneurons and it is unknown what subtypes are impaired in schizophrenia and contribute to brain dysfunction.

To identify subtypes of PV+ interneurons that are impaired in schizophrenia, we will implement 15q11.3 microdeletion mice, which exhibit schizophrenia-like behavior and will cross them with PV-Cre mice, such that Cre recombinase is expressed only on PV+ neurons. We will inject these mice with AAV-FLEX-GCaMP6s virus into the cortex resulting in the expression of the calcium indicator GCaMP6s, exclusively in PV+ neurons.

We will then assess the activity PV+ interneurons by means of calcium imaging technique in wild type and 15q13.3 mice. After the imaging, we will fix the sections and label by immunohistochemistry several subtype-specific markers of PV+ neurons. Since we will know activity for each PV+ neuron from calcium imaging and their subtype from immunohistochemistry, we will analyze how activity of each PV+ neuron subtype is affected in schizophrenia model and will identify those that have most dramatic changes, thus likely having the largest contribution to schizophrenia phenotype.

Methods: calcium imaging and electrophysiology in a slice preparation of the brain.

Scientific environment

The project is a collaboration between the labs of Konstantin Khodosevich (BRIC, UCPH) and Jean-François Perrier (Department of Neuroscience, UCPH). The candidate will be work under the daily supervision of Nikolaj Winther Hansen at the Department of Neuroscience (Mærsk Tower, Blegdamsvej 3, Copenhagen).

Your qualifications: You are highly motivated and studying Neuroscience, MedTek, KBS, Human Biology, Molecular Biomedicine. You are flexible, ambitious and can work independently.

Application 

Contact Jean-François Perrier (perrier@sund.ku.dk) including a CV and grade transcript.