Adaptive Synaptic Function and Neural Computation - Walter Lab

We investigate how synapses compute, adapt and remain functional across changing physiological conditions and neurological disease. By integrating quantitative neurophysiology, imaging, molecular biology and computational modelling, we uncover conserved mechanism of synaptic resilience. 

The Walter Lab studies the molecular principles that enable the nervous system to process information while remaining adaptable and resilient throughout development, learning, aging, and disease. We investigate presynaptic release sites as conserved hubs where molecular organization, neuronal activity, and cellular signaling converge to regulate neurotransmitter release and plasticity. We combine electrophysiology, imaging, molecular biology, computational modeling, and cross-species approaches to connect molecular mechanisms with neural computation. Integrating the genetic power of Drosophila with human induced pluripotent stem cell (iPSC)-derived neurons allows us to uncover conserved mechanisms of synaptic resilience and explore therapeutic strategies for neurological disease.