Rekling Lab

The aim of the research is to understand how neurons in small assemblies interact to produce sensory and motor functions in the brain.

Jens Rekling info

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Original papers

40. Jørgensen AB, Rasmussen CM, Rekling JC. µ-Opioid Receptor Activation Reduces Glutamate Release in the preBötzinger Complex in Organotypic Slice Cultures. J Neurosci. 2022 Sep 12;42(43):8066–77. doi: 10.1523/JNEUROSCI.1369-22.2022. Epub ahead of print. PMID: 36096669; PMCID: PMC9636991.

39. Mamedova E, Dmytriyeva O, Rekling JC. Thyrotropin-releasing hormone induces Ca2+ increase in a subset of vagal nodose ganglion neurons. Neuropeptides. 2022 Aug;94:102261.

38. Mamedova E, Árting LB, Rekling JC. Bile acids induce Ca2+ signaling and membrane permeabilizations in vagal nodose ganglion neurons. Biochem Biophys Rep. 2022 May 31;31:101288.

37. Torz, L, Niss, K, Lundh, S, Rekling, JC, Quintana, CD, Frazier, SED, Mercer, AJ, Cornea, A, Bertelsen, CV, Gerstenberg, MK, Hansen, AMK, Guldbrandt, M, Lykkesfeldt, J, John, LM, Villaescusa, C, Petersen, N. NPFF decreases activity of human arcuate NPY neurons: A study in embryonic stem cell-derived model. 2022. Int. J. Mol. Sci. 2022, 23(6), 3260;

36. Gómez, CD, Rasmussen, CM, Rekling, JC. GABAergic inhibition of presynaptic Ca2+ transients in respiratory preBötzinger neurons in organotypic slice cultures. eNeuro. 2021 Aug 23;8(4):ENEURO.0154-21.2021.

35. Czeisler CM, Silva TM, Fair SR, Liu J, Tupal S, Kaya B, Cowgill A, Mahajan S, Silva PE, Wang Y, Blissett AR, Göksel M, Borniger JC, Zhang N, Fernandes-Junior SA, Catacutan F, Alves MJ, Nelson RJ, Sundaresean V, Rekling J, Takakura AC, Moreira TS, Otero JJ. The Role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis. J Physiol 597.8 (2019) pp 2225–2251.

34. Egerod KL, Petersen N, Timshel PN, Rekling, JC, Wang Y, Liu Q, Schwartz TW, Gautron L. Profiling of G Protein-Coupled Receptors in Vagal Afferents Reveals Novel Gut-to-Brain Sensing Mechanisms. Mol Metab. 2018 Jun;12:62-75. doi: 10.1016/j.molmet.2018.03.016. Epub 2018 Apr 3.

33. Phillips WS, Del Negro CA, Rekling JC. Dendritic A-current in Rhythmically Active PreBötzinger Complex Neurons in Organotypic Cultures from Newborn Mice.J Neurosci. 2018 Feb 19. pii: 3342-17.

32. Phillips WS, Herly M, Del Negro CA, Rekling JC. (2015). Organotypic slice cultures containing the prebötzinger complex generate respiratory-like rhythms. J Neurophysiol. 2016 Feb 1;115(2):1063-70.

31. Harsløf, M, Müller, FC, Rohrberg, J., and Rekling, JC. (2015). Fast neuronal labeling in live tissue using a biocytin conjugated fluorescent probe. J. Neuroscience Methods 253, 101-109.

30. Kølvraa M, Müller FC, Jahnsen H, Rekling JC. (2014). Mechanisms contributing to cluster formation in the inferior olivary nucleus in brainstem slices from postnatal mice. J Physiol. Jan 1;592(Pt 1):33-47.

29. Apuschkin, M., Ougaard, M., and Rekling, JC. (2013) Spontaneous calcium waves in granule cells in cerebellar slice cultures. Neuroscience Letters 553, 78– 83.

28. Albert M, Schmitz SU, Kooistra SM, Malatesta M, Morales Torres C, Rekling JC, Johansen JV, Abarrategui I, Helin K. The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3. PLoS Genet. 2013 Apr;9(4):e1003461. doi: 10.1371/journal.pgen.1003461. Epub 2013 Apr 18.

27. Rekling J.C., Jensen K.H., Jahnsen H. (2012).Spontaneous cluster activity in the inferior olivary nucleus in brainstem slices from postnatal mice. J Physiol April 2012 590 (7) 1547-1562.

26. Lauridsen J.B., Johansen J.L., Rekling J.C., Thirstrup K., Moerk A. and Sager T.N. (2011). Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity. Neurosci Res. Jul;70(3):269-76.

25. Persson, K., and Rekling, J.C. (2011). Population calcium imaging of spontaneous respiratory- and novel motor activity in the facial nucleus and ventral brainstem in newborn mice- J. Physiol 589 (10): 2543–2558

24. Del Negro, C.A., Hayes, J.A., and Rekling, J.C. (2011). Dendritic calcium activity precedes inspiratory bursts in preBötzinger Complex neurons of neonatal mice recorded in vitro. J. Neuroscience. January 19, 2011 31(3):1017–1022

23. Jensen, K.H.R., and Rekling, J.C. (2010). Development of a no-wash assay for mitochondrial membrane potential using the styryl dye DASPEI. J. Biomolec. Screen. 15(9): 1071- 1081.

22. Tarras-Wahlberg, S., and Rekling, J.C. (2009). Hypoglossal motoneurons in newborn mice receive respiratory drive from both sides of the medulla. Neuroscience 161 (2009) 259–268.

21. Falk, S, and Rekling, J.C. (2009). Neurons in the prebötzinger complex and VRG are located in proximity to arterioles in newborn mice. Neuroscience Letters 450, 229–234.

20. Laursen, M and Rekling, J.C. (2006). The edinger-westphal nucleus of the juvenile rat contains transient- and repetitive-firing neurons. Neuroscience, 141; 191-200.

19. Rekling, J.C. (2004). NK-3 receptor activation depolarizes and induces an afterdepolarization in pyramidal neurons in gerbil cingulate cortex. Brain Research Bulletin 63 (2), 85-90.

18. Rekling, J.C. (2003) Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation. Neuroscience Letters, 335, 167-170.

17. Rekling, J.C., Shao,X.M., and Feldman, J.L. (2000). Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBötzinger Complex. J. Neuroscience 20(23): RC113, 1-5.

16. Rekling, J.C. (1999). Electrophysiological properties of brain stem neurons involved in motor control. University of Copenhagen. Doctoral Thesis.

15. Gray, P. A., Rekling, J. C., Bocchiaro, C. M., and Feldman, J. L. (1999). Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the Prebötzinger complex. Science 286 (5444): 1566-1568 (first and second author contributed equally to the work).

14. Zheng, Y., Riche, D, Rekling, J. C., Foutz, A. S. and Denavit Saubié, M. (1998). Brainstem neurons projecting to the rostral ventral respiratory group (rVRG) in the medulla of the rat revealed by co application of NMDA and biocytin. Brain Research 782 (1-2):113-125.

13. Rekling, J. C. and Feldman, J. L. (1997). Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. J. Neurophysiol. 78: 3508-3510.

12. Rekling, J. C. and Feldman, J. L. (1997). Calcium-dependent plateau potentials in rostral ambiguus neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 78: 2483-2492.

11. Rekling, J. C., Champagnat, J. and Denavit-Saubié, M. (1996). Thyrotropin-releasing hormone (TRH) depolarizes a subset of inspiratory neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 75 (2). 811-819.

10. Rekling, J. C. , Champagnat, J. and Denavit-Saubié, M. (1996). Electroresponsive properties and membrane potential trajectories of three types of inspiratory neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 75(2). 795-810.

9. Rekling, J. C. and Theophilidis, G. (1995). Effects of a pyrethroid insecticide, deltamethrin, on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice. Neuroscience Letters, 198. 189-192.

8. Rekling, J.C. (1993). Effects of met-enkephalin on GABAergic spontaneous miniature IPSPs in organotypic slice cultures of the rat hippocampus. J. Neuroscience, 13. 1954-1964.

7. Rekling, J. C. (1992). Interaction between thyrotropin-releasing hormone (TRH) and NMDA receptor mediated responses in hypoglossal motoneurones. Brain Research 578 (1/2). 289-296.

6. Rekling, J.C. (1990). Excitatory effects of thyrotropin releasing hormone (TRH) in hypoglos¬sal motoneurones. Brain Research 510. 175-179.

5. Rekling, J.C., Jahnsen, H., Mosfeldt Laursen, A. (1990). The effect of two lipophilic GABA uptake blockers in CA1 of the rat hippocampal slice. Br. J. Pharmacol. 99. 103-106.

4. Rekling, J.C., Mosfeldt Laursen, A. (1989). Evidence for a persistent sodium conduc¬tance in neurons from the nucleus prepositus hypoglossi. Brain Research 500. 276-286.

3. Mosfeldt Laursen, A., Rekling, J.C. (1989). Electrophysiological properties of hypoglossal motoneurones of guinea pigs studied in vitro. Neuroscience. 30(3), 619 637.

2. Kjoller, E., Rasmussen, C., Rekling J.C (1987). Beta blockers following acute myocardial infarct? Ugeskrift for Laeger 149: 50, 3397 3399.

1. Rekling, J.C. (1986) Molecular mechanisms and memory. Prize essay in medicine, Copenhagen University, awarded a gold medal.

Reviews

1. Rekling, J. C. and Feldman, J.L. (1998) Prebötzinger complex and pacemaker neurons: Hypothesized site and kernel for respiratory rhythm generation. Annual Review of Physiology vol 60: 385-405.

2. Rekling, J. C., Funk, G. D., Bayliss, D. A., Dong, X-W, and Feldman, J. L. (2000) Synaptic control of motoneuronal excitability. Physiological Reviews April 1; 80(2): 767-852.

Chapters in books

Møller, M., Micic, A., Rekling. J.C. (1997). Morphological characterization of rat pineal explant cultures. In: Neuroendocrinology: Retrospect and Perspectives (eds., H.-W. Korf and K.H. Usadel). chapter 27, pp.357-366. Springer-Verlag; Heidelberg, New York 1997.

W.-C. Li, J.C. Rekling. (2017). Chapter 11 - Electrical Coupling in the Generation of Vertebrate Motor Rhythms, Pages 243-264. Network Functions and Plasticity. Perspectives from Studying Neuronal Electrical Coupling in Microcircuits. Edited by:Jian Jing. Academic Press, 2017. ISBN: 978-0-12-803471-2

 

 

 

 

 

 

Lab members

Name Title Job responsibilities Image
Search in Name Search in Title Search in Job responsibilities
Andrea Siegl Master-Student Rekling Lab Billede af Andrea Siegl
Esmira Mamedova Postdoc Imig Lab, Rekling Lab Billede af Esmira Mamedova
Jens Christian Rekling Associate Professor Rekling Lab Billede af Jens Christian Rekling
Marco Stettler Master-Student Rekling Lab Billede af Marco Stettler
Morten Bjerre Laboratory Technician Rekling Lab, Kermen Lab Billede af Morten Bjerre