Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
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- Ride the wave: Retrograde trafficking becomes Ca2+ dependent with BAIAP3
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The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.
Original language | English |
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Journal | Journal of Cell Biology |
Volume | 216 |
Issue number | 7 |
Pages (from-to) | 1887-1889 |
Number of pages | 3 |
ISSN | 0021-9525 |
DOIs |
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Publication status | Published - 2017 |
- Animals, Exocytosis, Protein Transport, SNARE Proteins, Secretory Vesicles, trans-Golgi Network, Journal Article
Research areas
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ID: 185030281