Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

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The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

Original languageEnglish
JournalJournal of Cell Biology
Volume216
Issue number7
Pages (from-to)1887-1889
Number of pages3
ISSN0021-9525
DOIs
Publication statusPublished - 2017

    Research areas

  • Animals, Exocytosis, Protein Transport, SNARE Proteins, Secretory Vesicles, trans-Golgi Network, Journal Article

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