Søren Gøgsig Faarup Rasmussen

Søren Gøgsig Faarup Rasmussen

Associate Professor


  1. 1999
  2. Published

    Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI

    Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2000
  4. Published

    The effect of pH on ß2 adrenoceptor function

    Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2001
  6. Published

    Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6

    Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling

    Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter

    Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2002
  10. Published

    Structural basis for activation of G-protein-coupled receptors.

    Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Understanding G-protein coupled receptors and their role in the CNS

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  12. 2003
  13. Published

    Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy

    Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2005
  15. Published

    Purification and fluorescent labeling of the human serotonin transporter

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

    Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2006
  18. Published

    Molecular mechanisms of GPCR activation

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  19. 2007
  20. Published

    Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites

    Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

    Whorton, M. R., Bokoch, M. P., Rasmussen, Søren Gøgsig Faarup, Huang, B., Zare, R. N., Kobilka, B. & Sunahara, R. K., 1 May 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7682-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    A monoclonal antibody for G protein-coupled receptor crystallography

    Day, P. W., Rasmussen, Søren Gøgsig Faarup, Parnot, C., Fung, J. J., Masood, A., Kobilka, T. S., Yao, X., Choi, H., Weis, W. I., Rohrer, D. K. & Kobilka, B. K., Nov 2007, In: Nature Methods. 4, 11, p. 927-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

    Rasmussen, Søren Gøgsig Faarup, Choi, H., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., 15 Nov 2007, In: Nature. 450, 7168, p. 383-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

    Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Yao, X., Weis, W. I., Stevens, R. C. & Kobilka, B. K., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1266-73 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

    Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1258-65 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2008
  27. Published

    Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

    Richter, W., Day, P., Agrawal, R., Bruss, M. D., Granier, S., Wang, Y. L., Rasmussen, Søren Gøgsig Faarup, Horner, K., Wang, P., Lei, T., Patterson, A. J., Kobilka, B. & Conti, M., 23 Jan 2008, In: E M B O Journal. 27, 2, p. 384-93 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2009
  29. Published

    Crystal Structures of the ß2-Adrenergic Receptor

    Weis, W. I., Rosenbaum, D., Rasmussen, Søren Gøgsig Faarup & et. al, E. A., 2009, From Molecules to Medicines, Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Springer, p. 217-230 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  30. Published

    Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs

    Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    The structure and function of G-protein-coupled receptors

    Rosenbaum, D. M., Rasmussen, Søren Gøgsig Faarup & Kobilka, B. K., 21 May 2009, In: Nature. 459, 7245, p. 356-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

    Yao, X. J., Vélez Ruiz, G., Whorton, M. R., Rasmussen, Søren Gøgsig Faarup, DeVree, B. T., Deupi, X., Sunahara, R. K. & Kobilka, B., 9 Jun 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9501-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The beta2 Adrenergic Receptor as a Model for G Protein-Coupled Receptor Structure and Activation by Diffusible Hormones

    Rosenbaum, D., Rasmussen, Søren Gøgsig Faarup & Kobilka, B., Sep 2009, Handbook of Cell Signaling. Elsevier Editora

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  34. 2010
  35. Published

    Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

    Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

    Bokoch, M. P., Zou, Y., Rasmussen, Søren Gøgsig Faarup, Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., 7 Jan 2010, In: Nature. 463, 7277, p. 108-12 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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