Voltage-dependent amplification of synaptic inputs in respiratory motoneurones

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Voltage-dependent amplification of synaptic inputs in respiratory motoneurones. / Enríquez Denton, M; Wienecke, Jacob; Zhang, Mengliang; Hultborn, Hans; Kirkwood, P A.

In: Journal of Physiology, Vol. 590, No. 13, 2012, p. 3067-3090.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Enríquez Denton, M, Wienecke, J, Zhang, M, Hultborn, H & Kirkwood, PA 2012, 'Voltage-dependent amplification of synaptic inputs in respiratory motoneurones', Journal of Physiology, vol. 590, no. 13, pp. 3067-3090. https://doi.org/10.1113/jphysiol.2011.225789

APA

Enríquez Denton, M., Wienecke, J., Zhang, M., Hultborn, H., & Kirkwood, P. A. (2012). Voltage-dependent amplification of synaptic inputs in respiratory motoneurones. Journal of Physiology, 590(13), 3067-3090. https://doi.org/10.1113/jphysiol.2011.225789

Vancouver

Enríquez Denton M, Wienecke J, Zhang M, Hultborn H, Kirkwood PA. Voltage-dependent amplification of synaptic inputs in respiratory motoneurones. Journal of Physiology. 2012;590(13):3067-3090. https://doi.org/10.1113/jphysiol.2011.225789

Author

Enríquez Denton, M ; Wienecke, Jacob ; Zhang, Mengliang ; Hultborn, Hans ; Kirkwood, P A. / Voltage-dependent amplification of synaptic inputs in respiratory motoneurones. In: Journal of Physiology. 2012 ; Vol. 590, No. 13. pp. 3067-3090.

Bibtex

@article{20469beacb3a4405a6957b2886947991,
title = "Voltage-dependent amplification of synaptic inputs in respiratory motoneurones",
abstract = "Key points The processes whereby various excitatory and inhibitory inputs are integrated in spinal motoneurones during naturally occurring motor acts are not well understood, largely because there are amplifying mechanisms within the motoneurone that can control the effective strengths of the inputs. Knowledge of these processes is important in understanding conditions such as motoneurone disease, or the spasticity that can follow spinal cord injury or stroke Respiration is a natural motor act that continues normally under experimental conditions, and this study investigated, for the first time, the likely amplifying processes at work in respiratory motoneurones. In phrenic motoneurones, which control the most important respiratory muscle, the diaphragm, we found that the mechanism most favoured by investigations in other motoneurones, the activation of persistent inward currents via calcium channels, appears to make a very small contribution. Instead, modulation of synaptic currents (through NMDA channels) appears to be more important.",
author = "{Enr{\'i}quez Denton}, M and Jacob Wienecke and Mengliang Zhang and Hans Hultborn and Kirkwood, {P A}",
note = "CURIS 2012 5200 088",
year = "2012",
doi = "10.1113/jphysiol.2011.225789",
language = "English",
volume = "590",
pages = "3067--3090",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "13",

}

RIS

TY - JOUR

T1 - Voltage-dependent amplification of synaptic inputs in respiratory motoneurones

AU - Enríquez Denton, M

AU - Wienecke, Jacob

AU - Zhang, Mengliang

AU - Hultborn, Hans

AU - Kirkwood, P A

N1 - CURIS 2012 5200 088

PY - 2012

Y1 - 2012

N2 - Key points The processes whereby various excitatory and inhibitory inputs are integrated in spinal motoneurones during naturally occurring motor acts are not well understood, largely because there are amplifying mechanisms within the motoneurone that can control the effective strengths of the inputs. Knowledge of these processes is important in understanding conditions such as motoneurone disease, or the spasticity that can follow spinal cord injury or stroke Respiration is a natural motor act that continues normally under experimental conditions, and this study investigated, for the first time, the likely amplifying processes at work in respiratory motoneurones. In phrenic motoneurones, which control the most important respiratory muscle, the diaphragm, we found that the mechanism most favoured by investigations in other motoneurones, the activation of persistent inward currents via calcium channels, appears to make a very small contribution. Instead, modulation of synaptic currents (through NMDA channels) appears to be more important.

AB - Key points The processes whereby various excitatory and inhibitory inputs are integrated in spinal motoneurones during naturally occurring motor acts are not well understood, largely because there are amplifying mechanisms within the motoneurone that can control the effective strengths of the inputs. Knowledge of these processes is important in understanding conditions such as motoneurone disease, or the spasticity that can follow spinal cord injury or stroke Respiration is a natural motor act that continues normally under experimental conditions, and this study investigated, for the first time, the likely amplifying processes at work in respiratory motoneurones. In phrenic motoneurones, which control the most important respiratory muscle, the diaphragm, we found that the mechanism most favoured by investigations in other motoneurones, the activation of persistent inward currents via calcium channels, appears to make a very small contribution. Instead, modulation of synaptic currents (through NMDA channels) appears to be more important.

U2 - 10.1113/jphysiol.2011.225789

DO - 10.1113/jphysiol.2011.225789

M3 - Journal article

C2 - 22495582

VL - 590

SP - 3067

EP - 3090

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 13

ER -

ID: 40323449