Information to cerebellum on spinal motor networks mediated by the dorsal spinocerebellar tract
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Information to cerebellum on spinal motor networks mediated by the dorsal spinocerebellar tract. / Stecina, Katinka; Fedirchuk, Brent; Hultborn, Hans.
In: The Journal of Physiology, Vol. 591, No. Pt 22, 15.11.2013, p. 5433-43.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Information to cerebellum on spinal motor networks mediated by the dorsal spinocerebellar tract
AU - Stecina, Katinka
AU - Fedirchuk, Brent
AU - Hultborn, Hans
PY - 2013/11/15
Y1 - 2013/11/15
N2 - The main objective of this review is to re-examine the type of information transmitted by the dorsal and ventral spinocerebellar tracts (DSCT and VSCT respectively) during rhythmic motor actions such as locomotion. Based on experiments in the 1960s and 1970s, the DSCT was viewed as a relay of peripheral sensory input to the cerebellum in general, and during rhythmic movements such as locomotion and scratch. In contrast, the VSCT was seen as conveying a copy of the output of spinal neuronal circuitry, including those circuits generating rhythmic motor activity (the spinal central pattern generator, CPG). Emerging anatomical and electrophysiological information on the putative subpopulations of DSCT and VSCT neurons suggest differentiated functions for some of the subpopulations. Multiple lines of evidence support the notion that sensory input is not the only source driving DSCT neurons and, overall, there is a greater similarity between DSCT and VSCT activity than previously acknowledged. Indeed the majority of DSCT cells can be driven by spinal CPGs for locomotion and scratch without phasic sensory input. It thus seems natural to propose the possibility that CPG input to some of these neurons may contribute to distinguishing sensory inputs that are a consequence of the active locomotion from those resulting from perturbations in the external world.
AB - The main objective of this review is to re-examine the type of information transmitted by the dorsal and ventral spinocerebellar tracts (DSCT and VSCT respectively) during rhythmic motor actions such as locomotion. Based on experiments in the 1960s and 1970s, the DSCT was viewed as a relay of peripheral sensory input to the cerebellum in general, and during rhythmic movements such as locomotion and scratch. In contrast, the VSCT was seen as conveying a copy of the output of spinal neuronal circuitry, including those circuits generating rhythmic motor activity (the spinal central pattern generator, CPG). Emerging anatomical and electrophysiological information on the putative subpopulations of DSCT and VSCT neurons suggest differentiated functions for some of the subpopulations. Multiple lines of evidence support the notion that sensory input is not the only source driving DSCT neurons and, overall, there is a greater similarity between DSCT and VSCT activity than previously acknowledged. Indeed the majority of DSCT cells can be driven by spinal CPGs for locomotion and scratch without phasic sensory input. It thus seems natural to propose the possibility that CPG input to some of these neurons may contribute to distinguishing sensory inputs that are a consequence of the active locomotion from those resulting from perturbations in the external world.
KW - Animals
KW - Cerebellum
KW - Humans
KW - Locomotion
KW - Motor Activity
KW - Movement
KW - Neurons
KW - Spinal Cord
KW - Spinocerebellar Tracts
U2 - 10.1113/jphysiol.2012.249110
DO - 10.1113/jphysiol.2012.249110
M3 - Journal article
C2 - 23613538
VL - 591
SP - 5433
EP - 5443
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - Pt 22
ER -
ID: 120196876