Membrane Binding and Modulation of the PDZ Domain of PICK1
Research output: Contribution to journal › Review › Research › peer-review
Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.
Original language | English |
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Journal | Membranes |
Volume | 5 |
Issue number | 4 |
Pages (from-to) | 597-615 |
Number of pages | 19 |
ISSN | 2077-0375 |
DOIs | |
Publication status | Published - Dec 2015 |
- PDZ domains, lipid-binding domains, PICK1, scaffolding proteins
Research areas
ID: 160923949