Regulation and Function of AQP4 in the Central Nervous System

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Regulation and Function of AQP4 in the Central Nervous System. / Assentoft, Mette; Larsen, Brian Roland; MacAulay, Nanna.

In: Neurochemical Research, Vol. 40, No. 12, 12.2015, p. 2615-2627.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Assentoft, M, Larsen, BR & MacAulay, N 2015, 'Regulation and Function of AQP4 in the Central Nervous System', Neurochemical Research, vol. 40, no. 12, pp. 2615-2627. https://doi.org/10.1007/s11064-015-1519-z

APA

Assentoft, M., Larsen, B. R., & MacAulay, N. (2015). Regulation and Function of AQP4 in the Central Nervous System. Neurochemical Research, 40(12), 2615-2627. https://doi.org/10.1007/s11064-015-1519-z

Vancouver

Assentoft M, Larsen BR, MacAulay N. Regulation and Function of AQP4 in the Central Nervous System. Neurochemical Research. 2015 Dec;40(12):2615-2627. https://doi.org/10.1007/s11064-015-1519-z

Author

Assentoft, Mette ; Larsen, Brian Roland ; MacAulay, Nanna. / Regulation and Function of AQP4 in the Central Nervous System. In: Neurochemical Research. 2015 ; Vol. 40, No. 12. pp. 2615-2627.

Bibtex

@article{d574f7c72ce84b30a6937e49f8a366ad,
title = "Regulation and Function of AQP4 in the Central Nervous System",
abstract = "Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.",
author = "Mette Assentoft and Larsen, {Brian Roland} and Nanna MacAulay",
year = "2015",
month = dec,
doi = "10.1007/s11064-015-1519-z",
language = "English",
volume = "40",
pages = "2615--2627",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Regulation and Function of AQP4 in the Central Nervous System

AU - Assentoft, Mette

AU - Larsen, Brian Roland

AU - MacAulay, Nanna

PY - 2015/12

Y1 - 2015/12

N2 - Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.

AB - Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.

U2 - 10.1007/s11064-015-1519-z

DO - 10.1007/s11064-015-1519-z

M3 - Journal article

C2 - 25630715

VL - 40

SP - 2615

EP - 2627

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 12

ER -

ID: 137196496