Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume

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Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. / Soe, Rikke; Macaulay, Nanna; Klaerke, Dan Arne.

In: Neuroscience Letters, Vol. 457, No. 2, 06.2009, p. 80-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Soe, R, Macaulay, N & Klaerke, DA 2009, 'Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume', Neuroscience Letters, vol. 457, no. 2, pp. 80-4. https://doi.org/10.1016/j.neulet.2009.04.010

APA

Soe, R., Macaulay, N., & Klaerke, D. A. (2009). Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. Neuroscience Letters, 457(2), 80-4. https://doi.org/10.1016/j.neulet.2009.04.010

Vancouver

Soe R, Macaulay N, Klaerke DA. Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. Neuroscience Letters. 2009 Jun;457(2):80-4. https://doi.org/10.1016/j.neulet.2009.04.010

Author

Soe, Rikke ; Macaulay, Nanna ; Klaerke, Dan Arne. / Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. In: Neuroscience Letters. 2009 ; Vol. 457, No. 2. pp. 80-4.

Bibtex

@article{ef7f65805ca011dea8de000ea68e967b,
title = "Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume",
abstract = "The K+ channels Kir4.1 and Kir4.1-Kir5.1 are expressed in the glial cells of the CNS and are involved in regulation of the K+ homeostasis. Several studies have shown that Kir4.1 channels are co-localized with aquaporins (AQP4) in the glial endfeet, and a putative functional coupling between the Kir channels and aquaporins is therefore debated. To test a possible volume-sensitivity of the Kir channels, the Kir4.1 or Kir4.1-Kir5.1 channels were expressed in Xenopus oocytes with or without co-expression of aquaporins and subsequently exposed to cell volume alterations. Our results show an increase in Kir4.1 and Kir4.1-Kir5.1 currents upon swelling of the oocytes and a reduction in the current when the oocytes were shrunk. The volume-dependent changes in channel activity were not due to changes in the kinetics of the channels. These findings implicate a putative functional interaction between the Kir channels and aquaporins via small, fast cell volume changes in the glial cells.",
author = "Rikke Soe and Nanna Macaulay and Klaerke, {Dan Arne}",
year = "2009",
month = jun,
doi = "10.1016/j.neulet.2009.04.010",
language = "English",
volume = "457",
pages = "80--4",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume

AU - Soe, Rikke

AU - Macaulay, Nanna

AU - Klaerke, Dan Arne

PY - 2009/6

Y1 - 2009/6

N2 - The K+ channels Kir4.1 and Kir4.1-Kir5.1 are expressed in the glial cells of the CNS and are involved in regulation of the K+ homeostasis. Several studies have shown that Kir4.1 channels are co-localized with aquaporins (AQP4) in the glial endfeet, and a putative functional coupling between the Kir channels and aquaporins is therefore debated. To test a possible volume-sensitivity of the Kir channels, the Kir4.1 or Kir4.1-Kir5.1 channels were expressed in Xenopus oocytes with or without co-expression of aquaporins and subsequently exposed to cell volume alterations. Our results show an increase in Kir4.1 and Kir4.1-Kir5.1 currents upon swelling of the oocytes and a reduction in the current when the oocytes were shrunk. The volume-dependent changes in channel activity were not due to changes in the kinetics of the channels. These findings implicate a putative functional interaction between the Kir channels and aquaporins via small, fast cell volume changes in the glial cells.

AB - The K+ channels Kir4.1 and Kir4.1-Kir5.1 are expressed in the glial cells of the CNS and are involved in regulation of the K+ homeostasis. Several studies have shown that Kir4.1 channels are co-localized with aquaporins (AQP4) in the glial endfeet, and a putative functional coupling between the Kir channels and aquaporins is therefore debated. To test a possible volume-sensitivity of the Kir channels, the Kir4.1 or Kir4.1-Kir5.1 channels were expressed in Xenopus oocytes with or without co-expression of aquaporins and subsequently exposed to cell volume alterations. Our results show an increase in Kir4.1 and Kir4.1-Kir5.1 currents upon swelling of the oocytes and a reduction in the current when the oocytes were shrunk. The volume-dependent changes in channel activity were not due to changes in the kinetics of the channels. These findings implicate a putative functional interaction between the Kir channels and aquaporins via small, fast cell volume changes in the glial cells.

U2 - 10.1016/j.neulet.2009.04.010

DO - 10.1016/j.neulet.2009.04.010

M3 - Journal article

C2 - 19429167

VL - 457

SP - 80

EP - 84

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 2

ER -

ID: 12703867