Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target. / Loland, Claus J.; Sanchez, Connie; Plenge, Per; Bøgesø, Klaus P.; Bang-Andersen, Benny.

Allosterism in Drug Discovery. Royal Society of Chemistry, 2017. p. 360-380 (RSC Drug Discovery Series; No. 56).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Loland, CJ, Sanchez, C, Plenge, P, Bøgesø, KP & Bang-Andersen, B 2017, Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target. in Allosterism in Drug Discovery. Royal Society of Chemistry, RSC Drug Discovery Series, no. 56, pp. 360-380. https://doi.org/10.1039/9781782629276-00360

APA

Loland, C. J., Sanchez, C., Plenge, P., Bøgesø, K. P., & Bang-Andersen, B. (2017). Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target. In Allosterism in Drug Discovery (pp. 360-380). Royal Society of Chemistry. RSC Drug Discovery Series No. 56 https://doi.org/10.1039/9781782629276-00360

Vancouver

Loland CJ, Sanchez C, Plenge P, Bøgesø KP, Bang-Andersen B. Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target. In Allosterism in Drug Discovery. Royal Society of Chemistry. 2017. p. 360-380. (RSC Drug Discovery Series; No. 56). https://doi.org/10.1039/9781782629276-00360

Author

Loland, Claus J. ; Sanchez, Connie ; Plenge, Per ; Bøgesø, Klaus P. ; Bang-Andersen, Benny. / Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target. Allosterism in Drug Discovery. Royal Society of Chemistry, 2017. pp. 360-380 (RSC Drug Discovery Series; No. 56).

Bibtex

@inbook{200ecda215e042efa7d1e6ce99f32495,
title = "Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target",
abstract = "The serotonin transporter (SERT) is an important drug target and the majority of currently used antidepressants are potent inhibitors of SERT, binding primarily to the substrate binding site. However, even though the existence of an allosteric modulator site was realized more than 30 years ago, the research into this mechanism is still in its early days. The current knowledge about the allosteric site with respect to pharmacology, structure and function, and pharmacological tool compounds, is reviewed and a perspective is given on its potential as a drug target.",
author = "Loland, {Claus J.} and Connie Sanchez and Per Plenge and B{\o}ges{\o}, {Klaus P.} and Benny Bang-Andersen",
year = "2017",
doi = "10.1039/9781782629276-00360",
language = "English",
isbn = "978-1-78262-459-2",
series = "RSC Drug Discovery Series",
publisher = "Royal Society of Chemistry",
number = "56",
pages = "360--380",
booktitle = "Allosterism in Drug Discovery",
address = "United Kingdom",

}

RIS

TY - CHAP

T1 - Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target

AU - Loland, Claus J.

AU - Sanchez, Connie

AU - Plenge, Per

AU - Bøgesø, Klaus P.

AU - Bang-Andersen, Benny

PY - 2017

Y1 - 2017

N2 - The serotonin transporter (SERT) is an important drug target and the majority of currently used antidepressants are potent inhibitors of SERT, binding primarily to the substrate binding site. However, even though the existence of an allosteric modulator site was realized more than 30 years ago, the research into this mechanism is still in its early days. The current knowledge about the allosteric site with respect to pharmacology, structure and function, and pharmacological tool compounds, is reviewed and a perspective is given on its potential as a drug target.

AB - The serotonin transporter (SERT) is an important drug target and the majority of currently used antidepressants are potent inhibitors of SERT, binding primarily to the substrate binding site. However, even though the existence of an allosteric modulator site was realized more than 30 years ago, the research into this mechanism is still in its early days. The current knowledge about the allosteric site with respect to pharmacology, structure and function, and pharmacological tool compounds, is reviewed and a perspective is given on its potential as a drug target.

U2 - 10.1039/9781782629276-00360

DO - 10.1039/9781782629276-00360

M3 - Book chapter

AN - SCOPUS:85006355217

SN - 978-1-78262-459-2

T3 - RSC Drug Discovery Series

SP - 360

EP - 380

BT - Allosterism in Drug Discovery

PB - Royal Society of Chemistry

ER -

ID: 188452966