Claus Juul Løland
Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
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Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, , 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability
Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
Hussain, H., Du, Y., Scull, N. J., Mortensen, Jonas Sigurd, Tarrasch, J., Bae, H. E., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 17 May 2016, In: Chemistry: A European Journal. 22, 21, p. 7068-7073 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability
Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.Research output: Contribution to journal › Journal article › Research › peer-review
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Jagalski, V., Barker, R. D., Thygesen, Mikkel Boas, Gotfryd, K., Krüger, M. B., Shi, L., Maric, S., Bovet, N. E., Moulin, M., Haertlein, M., Pomorski, Thomas Guenther, Loland, Claus Juul & Cardenas Gomez, M., 2015, In: Soft Matter. 11, 39, p. 7707-7711 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The binding sites for benztropines and dopamine in the dopamine transporter overlap
Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM
Kalenderoglou, I. E., Plenge, P., Yang, D., Salomon, K., Laursen, L., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2022, In: Biophysical Journal. 121, 3, p. 26-26 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799Research output: Contribution to journal › Journal article › Research › peer-review
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Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An intracellular interaction network regulates conformational transitions in the dopamine transporter.
Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Realizing integration in structural biology: The 2022 ISBUC Annual Meeting
Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754Research output: Contribution to journal › Journal article › Research › peer-review
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SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity
Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study
Lee, H. J., Ehsan, M., Zhang, X., Katsube, S., Munk, C. F., Wang, H., Ahmed, W., Kumar, A., Byrne, B., Loland, Claus Juul, Guan, L., Liu, X. & Chae, P. S., 2022, In: Chemical Science. 13, p. 5750-5759 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability
Lee, H. S., Das, M., Mahler, F., Ahmed, W., Wang, H., Mortensen, Jonas Sigurd, Hariharan, P., Ghani, L., Byrne, B., Guan, L., Loland, Claus Juul, Keller, S. & Chae, P. S., 2022, In: Chemistry - An Asian Journal. 17, 24, 9 p., e202200941.Research output: Contribution to journal › Journal article › Research › peer-review
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R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse
Loland, Claus Juul, Mereu, M., Okunola, O. M., Cao, J., Prisinzano, T. E., Mazier, S., Kopajtic, T., Shi, L., Katz, J. L., Tanda, G. & Newman, A. H., Sep 2012, In: Biological Psychiatry. 72, 5, p. 405-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target
Loland, Claus Juul, Sanchez, C., Plenge, P., Bøgesø, K. P. & Bang-Andersen, B., 2017, Allosterism in Drug Discovery. Royal Society of Chemistry, p. 360-380 21 p. (RSC Drug Discovery Series; No. 56).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4359
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
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A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Research output: Contribution to journal › Journal article › Research › peer-review
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