Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice. / Bellardita, Carmelo; Caggiano, Vittorio; Leiras, Roberto; Caldeira, Vanessa; Fuchs, Andrea; Bouvier, Julien; Löw, Peter; Kiehn, Ole.
In: eLife, Vol. 6, e23011, 13.02.2017.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice
AU - Bellardita, Carmelo
AU - Caggiano, Vittorio
AU - Leiras, Roberto
AU - Caldeira, Vanessa
AU - Fuchs, Andrea
AU - Bouvier, Julien
AU - Löw, Peter
AU - Kiehn, Ole
PY - 2017/2/13
Y1 - 2017/2/13
N2 - Spasms after spinal cord injury (SCI) are debilitating involuntary muscle contractions that have been associated with increased motor neuron excitability and decreased inhibition. However, whether spasms involve activation of premotor spinal excitatory neuronal circuits is unknown. Here we use mouse genetics, electrophysiology, imaging and optogenetics to directly target major classes of spinal interneurons as well as motor neurons during spasms in a mouse model of chronic SCI. We find that assemblies of excitatory spinal interneurons are recruited by sensory input into functional circuits to generate persistent neural activity, which interacts with both the graded expression of plateau potentials in motor neurons to generate spasms, and inhibitory interneurons to curtail them. Our study reveals hitherto unrecognized neuronal mechanisms for the generation of persistent neural activity under pathophysiological conditions, opening up new targets for treatment of muscle spasms after SCI.
AB - Spasms after spinal cord injury (SCI) are debilitating involuntary muscle contractions that have been associated with increased motor neuron excitability and decreased inhibition. However, whether spasms involve activation of premotor spinal excitatory neuronal circuits is unknown. Here we use mouse genetics, electrophysiology, imaging and optogenetics to directly target major classes of spinal interneurons as well as motor neurons during spasms in a mouse model of chronic SCI. We find that assemblies of excitatory spinal interneurons are recruited by sensory input into functional circuits to generate persistent neural activity, which interacts with both the graded expression of plateau potentials in motor neurons to generate spasms, and inhibitory interneurons to curtail them. Our study reveals hitherto unrecognized neuronal mechanisms for the generation of persistent neural activity under pathophysiological conditions, opening up new targets for treatment of muscle spasms after SCI.
U2 - 10.7554/eLife.23011
DO - 10.7554/eLife.23011
M3 - Journal article
C2 - 28191872
AN - SCOPUS:85014439465
VL - 6
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e23011
ER -
ID: 194975924