Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release
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Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. / Sigler, Albrecht; Oh, Won Chan; Imig, Cordelia; Altas, Bekir; Kawabe, Hiroshi; Cooper, Benjamin H; Kwon, Hyung-Bae; Rhee, Jeong-Seop; Brose, Nils.
In: Neuron, Vol. 94, No. 2, 19.04.2017, p. 304-311.e4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release
AU - Sigler, Albrecht
AU - Oh, Won Chan
AU - Imig, Cordelia
AU - Altas, Bekir
AU - Kawabe, Hiroshi
AU - Cooper, Benjamin H
AU - Kwon, Hyung-Bae
AU - Rhee, Jeong-Seop
AU - Brose, Nils
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/4/19
Y1 - 2017/4/19
N2 - Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.
AB - Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.
KW - Animals
KW - Calcium/metabolism
KW - Dendrites/metabolism
KW - Dendritic Spines/metabolism
KW - Glutamic Acid/metabolism
KW - Hippocampus/metabolism
KW - Mice
KW - Signal Transduction/physiology
KW - Synapses/metabolism
U2 - 10.1016/j.neuron.2017.03.029
DO - 10.1016/j.neuron.2017.03.029
M3 - Journal article
C2 - 28426965
VL - 94
SP - 304-311.e4
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 2
ER -
ID: 237697748