Neuronal activity dynamics in the dentate gyrus during early epileptogenesis
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Neuronal activity dynamics in the dentate gyrus during early epileptogenesis. / Berglind, Fredrik; Boulot, Adrien; Gonzalez-Ramos, Ana; Melin, Esbjörn; Bono, Antonino; Sørensen, Andreas Toft; Ledri, Marco.
In: Epilepsy Research, Vol. 194, 107182, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neuronal activity dynamics in the dentate gyrus during early epileptogenesis
AU - Berglind, Fredrik
AU - Boulot, Adrien
AU - Gonzalez-Ramos, Ana
AU - Melin, Esbjörn
AU - Bono, Antonino
AU - Sørensen, Andreas Toft
AU - Ledri, Marco
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We find that while granule cells are active 8 h after SE and then gradually decrease their activity, Calretinin-positive mossy cells and Neuropeptide Y-positive GABAergic interneurons in the hilus show a delayed activation pattern starting at 24 and peaking at 48 h after SE. These data suggest that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epileptogenesis, and contribute to our understanding of the complex role of these cells in normal and pathological conditions.
AB - Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We find that while granule cells are active 8 h after SE and then gradually decrease their activity, Calretinin-positive mossy cells and Neuropeptide Y-positive GABAergic interneurons in the hilus show a delayed activation pattern starting at 24 and peaking at 48 h after SE. These data suggest that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epileptogenesis, and contribute to our understanding of the complex role of these cells in normal and pathological conditions.
KW - Calretinin
KW - Epileptogenesis
KW - Kainic Acid
KW - Mossy Cells
KW - RAM
U2 - 10.1016/j.eplepsyres.2023.107182
DO - 10.1016/j.eplepsyres.2023.107182
M3 - Journal article
C2 - 37364343
AN - SCOPUS:85162889215
VL - 194
JO - Journal of Epilepsy
JF - Journal of Epilepsy
SN - 0920-1211
M1 - 107182
ER -
ID: 358967447