Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

Research output: Working paper › Preprint › Research

Standard

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS. / Mora, Santiago; Friis, Rasmus von Huth; Stuckert, Anna; Noes-Holt, Gith; Montañana-Rosell, Roser; Sørensen, Andreas Toft; Selvan, Raghavendra; Allodi, Ilary.

2022.

Research output: Working paper › Preprint › Research

Harvard

Mora, S, Friis, RVH, Stuckert, A, Noes-Holt, G, Montañana-Rosell, R, Sørensen, AT, Selvan, R & Allodi, I 2022 'Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS'. https://doi.org/10.1101/2022.12.15.520568

APA

Mora, S., Friis, R. V. H., Stuckert, A., Noes-Holt, G., Montañana-Rosell, R., Sørensen, A. T., Selvan, R., & Allodi, I. (2022). Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS. bioRxiv https://doi.org/10.1101/2022.12.15.520568

Vancouver

Mora S, Friis RVH, Stuckert A, Noes-Holt G, Montañana-Rosell R, Sørensen AT et al. Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS. 2022. https://doi.org/10.1101/2022.12.15.520568

Author

Mora, Santiago ; Friis, Rasmus von Huth ; Stuckert, Anna ; Noes-Holt, Gith ; Montañana-Rosell, Roser ; Sørensen, Andreas Toft ; Selvan, Raghavendra ; Allodi, Ilary. / Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS. 2022. (bioRxiv).

Bibtex

@techreport{fb9bcc9444aa494baee1401d59fea5b7,
title = "Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS",
abstract = "Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms",
author = "Santiago Mora and Friis, {Rasmus von Huth} and Anna Stuckert and Gith Noes-Holt and Roser Monta{\~n}ana-Rosell and S{\o}rensen, {Andreas Toft} and Raghavendra Selvan and Ilary Allodi",
year = "2022",
doi = "10.1101/2022.12.15.520568",
language = "English",
series = "bioRxiv",
type = "WorkingPaper",

}

RIS

TY - UNPB

T1 - Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

AU - Mora, Santiago

AU - Friis, Rasmus von Huth

AU - Stuckert, Anna

AU - Noes-Holt, Gith

AU - Montañana-Rosell, Roser

AU - Sørensen, Andreas Toft

AU - Selvan, Raghavendra

AU - Allodi, Ilary

PY - 2022

Y1 - 2022

N2 - Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms

AB - Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms

U2 - 10.1101/2022.12.15.520568

DO - 10.1101/2022.12.15.520568

M3 - Preprint

T3 - bioRxiv

BT - Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

ER -

ID: 333688722