FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro. / Allodi, Ilary; Casals-Díaz, Laura; Santos-Nogueira, Eva; Gonzalez-Perez, Francisco; Navarro, Xavier; Udina, Esther.

In: Molecular Neurobiology, Vol. 47, No. 2, 2013, p. 770-781.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Allodi, I, Casals-Díaz, L, Santos-Nogueira, E, Gonzalez-Perez, F, Navarro, X & Udina, E 2013, 'FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro', Molecular Neurobiology, vol. 47, no. 2, pp. 770-781. https://doi.org/10.1007/s12035-012-8389-z

APA

Allodi, I., Casals-Díaz, L., Santos-Nogueira, E., Gonzalez-Perez, F., Navarro, X., & Udina, E. (2013). FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro. Molecular Neurobiology, 47(2), 770-781. https://doi.org/10.1007/s12035-012-8389-z

Vancouver

Allodi I, Casals-Díaz L, Santos-Nogueira E, Gonzalez-Perez F, Navarro X, Udina E. FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro. Molecular Neurobiology. 2013;47(2):770-781. https://doi.org/10.1007/s12035-012-8389-z

Author

Allodi, Ilary ; Casals-Díaz, Laura ; Santos-Nogueira, Eva ; Gonzalez-Perez, Francisco ; Navarro, Xavier ; Udina, Esther. / FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro. In: Molecular Neurobiology. 2013 ; Vol. 47, No. 2. pp. 770-781.

Bibtex

@article{2f24e1177f23430eb8d9d445323fe621,
title = "FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro",
abstract = "In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.",
keywords = "Animals, Animals, Newborn, Cells, Cultured, Female, Fibroblast Growth Factor 2/pharmacology, Ganglia, Spinal/cytology, Motor Neurons/cytology, Neurites/drug effects, Neurogenesis/drug effects, Organ Culture Techniques, Rats, Rats, Sprague-Dawley, Spinal Cord/cytology",
author = "Ilary Allodi and Laura Casals-D{\'i}az and Eva Santos-Nogueira and Francisco Gonzalez-Perez and Xavier Navarro and Esther Udina",
year = "2013",
doi = "10.1007/s12035-012-8389-z",
language = "English",
volume = "47",
pages = "770--781",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

AU - Allodi, Ilary

AU - Casals-Díaz, Laura

AU - Santos-Nogueira, Eva

AU - Gonzalez-Perez, Francisco

AU - Navarro, Xavier

AU - Udina, Esther

PY - 2013

Y1 - 2013

N2 - In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

AB - In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

KW - Animals

KW - Animals, Newborn

KW - Cells, Cultured

KW - Female

KW - Fibroblast Growth Factor 2/pharmacology

KW - Ganglia, Spinal/cytology

KW - Motor Neurons/cytology

KW - Neurites/drug effects

KW - Neurogenesis/drug effects

KW - Organ Culture Techniques

KW - Rats

KW - Rats, Sprague-Dawley

KW - Spinal Cord/cytology

U2 - 10.1007/s12035-012-8389-z

DO - 10.1007/s12035-012-8389-z

M3 - Journal article

C2 - 23275175

VL - 47

SP - 770

EP - 781

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 2

ER -

ID: 227433872