Avoidance and inhibitory control are possible transdiagnostic traits? A systematic review in animal models
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Avoidance and inhibitory control are possible transdiagnostic traits? A systematic review in animal models. / Olmedo-Córdoba, Manuela; Moreno-Montoya, Margarita; Mora, Santiago; Prados-Pardo, Ángeles; Martín-González, Elena.
In: Behavioural Brain Research, Vol. 451, 114500, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Avoidance and inhibitory control are possible transdiagnostic traits? A systematic review in animal models
AU - Olmedo-Córdoba, Manuela
AU - Moreno-Montoya, Margarita
AU - Mora, Santiago
AU - Prados-Pardo, Ángeles
AU - Martín-González, Elena
N1 - Publisher Copyright: © 2023 Elsevier B.V.
PY - 2023
Y1 - 2023
N2 - In clinical research, aberrant avoidance behavior and inhibitory control deficit have a high comorbidity in different psychopathological disorders. Therefore, avoidance and impulsive and/or compulsive behaviors might be classified as transdiagnostic traits, where the assessment through animal models could address evidence of their contribution as neurobehavioral mechanisms in psychopathology. The objective of the present review has been to assess the avoidance trait and the implication of inhibitory control behaviors, through studies using passive and active avoidance tests in rodents, and a preclinical model using selective breeding of high- or low-avoidance Roman rats (RHA, RLA). A systematic search strategy was carried out in the PubMed and Web of Science databases, where a total of 40 studies were accepted in the qualitative synthesis. The results of the different studies reviewed pointed to a relation between a reduced avoidance profile in passive avoidance (PA) with impulsive decision making and novelty-seeking behaviors; an increased avoidance profile in PA with compulsive drinking; a high active avoidance profile, including RHA rats, with different types of impulsivity and novelty- seeking behaviors; and regarding compulsivity depending on its measure, a low active avoidance profile, including RLA rats, has been associated with increased anxiety in the EPM and increased grooming, while a high active avoidance profile, including RHA rats, has been associated with increased rearing, compulsive drinking including alcohol, and cognitive inflexibility. The results have been discussed in terms of environmental factors and the underlying mechanisms between these possible transdiagnostic traits in psychopathology.
AB - In clinical research, aberrant avoidance behavior and inhibitory control deficit have a high comorbidity in different psychopathological disorders. Therefore, avoidance and impulsive and/or compulsive behaviors might be classified as transdiagnostic traits, where the assessment through animal models could address evidence of their contribution as neurobehavioral mechanisms in psychopathology. The objective of the present review has been to assess the avoidance trait and the implication of inhibitory control behaviors, through studies using passive and active avoidance tests in rodents, and a preclinical model using selective breeding of high- or low-avoidance Roman rats (RHA, RLA). A systematic search strategy was carried out in the PubMed and Web of Science databases, where a total of 40 studies were accepted in the qualitative synthesis. The results of the different studies reviewed pointed to a relation between a reduced avoidance profile in passive avoidance (PA) with impulsive decision making and novelty-seeking behaviors; an increased avoidance profile in PA with compulsive drinking; a high active avoidance profile, including RHA rats, with different types of impulsivity and novelty- seeking behaviors; and regarding compulsivity depending on its measure, a low active avoidance profile, including RLA rats, has been associated with increased anxiety in the EPM and increased grooming, while a high active avoidance profile, including RHA rats, has been associated with increased rearing, compulsive drinking including alcohol, and cognitive inflexibility. The results have been discussed in terms of environmental factors and the underlying mechanisms between these possible transdiagnostic traits in psychopathology.
KW - Active avoidance
KW - Avoidance
KW - Compulsivity
KW - Impulsivity
KW - Inhibitory control
KW - Passive avoidance
KW - RHA
KW - RLA
U2 - 10.1016/j.bbr.2023.114500
DO - 10.1016/j.bbr.2023.114500
M3 - Review
C2 - 37207979
AN - SCOPUS:85160081940
VL - 451
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
M1 - 114500
ER -
ID: 348164311