Alexander Matthias Walter
Associate Professor - Promotion Programme
Molecular & theoretical neuroscience
Blegdamsvej 3B, 2200 København N
A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling
Podufall, J., Tian, R., Knoche, E., Puchkov, D., Walter, Alexander Matthias, Rosa, S., Quentin, C., Vukoja, A., Jung, N., Lampe, A., Wichmann, C., Böhme, M., Depner, H., Zhang, Y. Q., Schmoranzer, J., Sigrist, S. J. & Haucke, V., 2014, In: Cell Reports. 7, 5, p. 1417-1425 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sequential vesicle pool model with a single release sensor and a ca(2+)-dependent priming catalyst effectively explains ca(2+)-dependent properties of neurosecretion
Walter, Alexander Matthias, da Silva Pinheiro, P. C., Verhage, M. & Sørensen, Jakob Balslev, Dec 2013, In: P L o S Computational Biology (Online). 9, 12, p. 1-15 15 p., e1003362.Research output: Contribution to journal › Journal article › Research › peer-review
Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses
Fulterer, A., Andlauer, T. F. M., Ender, A., Maglione, M., Eyring, K., Woitkuhn, J., Lehmann, M., Matkovic-Rachid, T., Geiger, J. R. P., Walter, Alexander Matthias, Nagel, K. I. & Sigrist, S. J., 1 May 2018, In: Cell Reports. 23, 5, p. 1259-1274 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling
Böhme, M. A., Beis, C., Reddy-Alla, S., Reynolds, E., Mampell, M. M., Grasskamp, A. T., Lützkendorf, J., Bergeron, D. D., Driller, J. H., Babikir, H., Göttfert, F., Robinson, I. M., O'Kane, C. J., Hell, S. W., Wahl, M. C., Stelzl, U., Loll, B., Walter, Alexander Matthias & Sigrist, S. J., 2016, In: Nature Neuroscience. 19, 10, p. 1311-1320 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
Schotten, S., Meijer, M., Walter, Alexander Matthias, Huson, V., Mamer, L., Kalogreades, L., Ter Veer, M., Ruiter, M., Brose, N., Rosenmund, C., Sørensen, Jakob Balslev, Verhage, M. & Cornelisse, L. N., 2015, In: eLife. 4, p. 1-25 25 p., e05531.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric stabilization of calcium and lipid binding engages three synaptotagmins in fast exocytosis
Kobbersmed, J. R. L., Berns, M. M. M., Ditlevsen, Susanne, Sørensen, Jakob Balslev & Walter, Alexander Matthias, 23 Oct 2021, bioRxiv, p. 1-56.Research output: Working paper › Preprint › Research
- Published
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Kobbersmed, J. R. L., Berns, M. M. M., Ditlevsen, Susanne, Sørensen, Jakob Balslev & Walter, Alexander Matthias, 2022, In: eLife. 11, 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses
Kononenko, N. L., Puchkov, D., Classen, G. A., Walter, Alexander Matthias, Pechstein, A., Sawade, L., Kaempf, N., Trimbuch, T., Lorenz, D., Rosenmund, C., Maritzen, T. & Haucke, V., 4 Jun 2014, In: Neuron. 82, 5, p. 981-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release
da Silva Pinheiro, P. C., de Wit, H., Walter, Alexander Matthias, Groffen, A. J., Verhage, M. & Sørensen, Jakob Balslev, 16 Oct 2013, In: Journal of Neuroscience. 33, 42, p. 16459-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling
Walter, Alexander Matthias, Uesaka, N. & Midorikawa, M., 2023, In: Frontiers in Cellular Neuroscience. 17, 3 p., 1213640.Research output: Contribution to journal › Editorial › Research › peer-review
Functional architecture of the synaptic transducers at a central glutamatergic synapse
Brockmann, M., Toulme, E., Grasskamp, A., Trimbuch, T., Südhof, T., Walter, Alexander Matthias & Rosenmund, C., 2020, 1 p.Research output: Working paper › Preprint › Research
- Published
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply and is required for motor function
Boehme, M., McCarthy, A., Blaum, N., Berezeckaja, M., Ponimaskine, K., Schwefel, D. & Walter, Alexander Matthias, 2021, p. E310. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Böhme, M. A., McCarthy, A. W., Blaum, N., Berezeckaja, M., Ponimaskine, K., Schwefel, D. & Walter, Alexander Matthias, 2021, In: Glia. 69, 8, p. 1897-1915 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Goel, P., Dufour Bergeron, D., Böhme, M. A., Nunnelly, L., Lehmann, M., Buser, C., Walter, Alexander Matthias, Sigrist, S. J. & Dickman, D., 2019, In: The Journal of Cell Biology. 218, 5, p. 1706-1724 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation
Ghelani, Tina, Escher, M., Thomas, U., Esch, K., Lützkendorf, J., Depner, H., Maglione, M., Parutto, P., Gratz, S., Matkovic-Rachid, T., Ryglewski, S., Walter, Alexander Matthias, Holcman, D., O'Connor Giles, K., Heine, M. & Sigrist, S. J., 2023, In: Science Advances. 9, 7, 21 p., eade7804.Research output: Contribution to journal › Journal article › Research › peer-review
Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Schuhmacher, M., Grasskamp, A. T., Barahtjan, P., Wagner, N., Lombardot, B., Schuhmacher, J. S., Sala, P., Lohmann, A., Henry, I., Shevchenko, A., Coskun, Ü., Walter, Alexander Matthias & Nadler, A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 7729-7738 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
Walter, Alexander Matthias, Groffen, A. J., Sørensen, Jakob Balslev & Verhage, M., 2011, In: Trends in Neurosciences. 34, 9, p. 487-97 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Walter, Alexander Matthias, Müller, R., Tawfik, B., Wierda, K. D., Pinheiro, P. S., Nadler, A., McCarthy, A. W., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Lehmann, M., Haucke, V., Hille, B., Schultz, C. & Sørensen, Jakob Balslev, 2017, In: eLife. 6, 41 p., e30203.Research output: Contribution to journal › Journal article › Research › peer-review
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
Muhammad, K., Reddy-Alla, S., Driller, J. H., Schreiner, D., Rey, U., Böhme, M. A., Hollmann, C., Ramesh, N., Depner, H., Lützkendorf, J., Matkovic, T., Götz, T., Bergeron, D. D., Schmoranzer, J., Goettfert, F., Holt, M., Wahl, M. C., Hell, S. W., Scheiffele, P., Walter, A. M. & 2 others, , 2015, In: Nature Communications. 6, 15 p., 8362.Research output: Contribution to journal › Journal article › Research › peer-review
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
Grauel, M. K., Maglione, M., Reddy-Alla, S., Willmes, C. G., Brockmann, M. M., Trimbuch, T., Rosenmund, T., Pangalos, M., Vardar, G., Stumpf, A., Walter, Alexander Matthias, Rost, B. R., Eickholt, B. J., Haucke, V., Schmitz, D., Sigrist, S. J. & Rosenmund, C., 11 Oct 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. 11615-11620 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rapid active zone remodeling consolidates presynaptic potentiation
Böhme, M. A., McCarthy, A. W., Grasskamp, A. T., Beuschel, C. B., Goel, P., Jusyte, M., Laber, D., Huang, S., Rey, U., Petzoldt, A. G., Lehmann, M., Göttfert, F., Haghighi, P., Hell, S. W., Owald, D., Dickman, D., Sigrist, S. J. & Walter, Alexander Matthias, 2019, In: Nature Communications. 10, 1, 16 p., 1085.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle: Ca2+ channel distances
Kobbersmed, J. R. L., Grasskamp, A. T., Jusyte, M., Boehme, M. A., Ditlevsen, Susanne, Sørensen, Jakob Balslev & Walter, Alexander Matthias, 2020, In: eLife. 9, 48 p., e51032.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rate-limiting recovery processes in neurotransmission under sustained stimulation
Ernst, A., Unger, N., Schütte, C., Walter, Alexander Matthias & Winkelmann, S., 2023, In: Mathematical Biosciences. 362, 15 p., 109023.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of synaptic release-site Ca2+ channel coupling as a mechanism to control release probability and short-term plasticity.
Böhme, M., Grasskamp, A. & Walter, Alexander Matthias, Jul 2018, In: FEBS Letters. p. 3516-3531 16 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Grasskamp, A. T., Jusyte, M., McCarthy, A. W., Götz, T. W. B., Ditlevsen, Susanne & Walter, Alexander Matthias, 2023, In: Frontiers in Cellular Neuroscience. 17, 1129417.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33920160
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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle: Ca2+ channel distances
Research output: Contribution to journal › Journal article › Research › peer-review
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Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Research output: Contribution to journal › Journal article › Research › peer-review
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