Nanna MacAulay
Professor
Molecular Neuroscience
Blegdamsvej 3
2200 København N.
- 2018
- Published
Cotransporter-mediated water transport underlying cerebrospinal fluid formation
Steffensen, Annette Buur, Oernbo, E. K., Stoica, A., Gerkau, N. J., Barbuskaite, Dagne, Tritsaris, Katerina, Rose, C. R. & MacAulay, Nanna, 2018, In: Nature Communications. 9, 1, 13 p., 2167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?
Toft-Bertelsen, Trine Lisberg, Larsen, B. R. & MacAulay, Nanna, 2018, In: Channels (Austin). 12, 1, p. 100-108Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms
Larsen, B. R. & MacAulay, Nanna, Oct 2017, In: Glia. 65, 10, p. 1668-1681 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic connexin hemichannels are regulated by PKC phosphorylation in an isoform-specific manner
MacAulay, Nanna, Alstrom, J. S., Hansen, D. B. & Nielsen, Morten Schak, 2017, In: Glia. 65, S1, p. E64-E64 S17-01.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics
Nielsen, B. S., Hansen, D. B., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, Sep 2017, In: Neurochemical Research. 42, 9, p. 2537–2550 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Permeant-specific gating of connexin 30 hemichannels
Nielsen, B. S., Alstrom, J. S., Nicholson, B., Nielsen, Morten Schak & MacAulay, Nanna, 2017, In: Journal of Biological Chemistry. 292, 49, p. 19999-20009Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells
Rosenbaek, L. L., Rizzo, F., MacAulay, Nanna, Staub, O. & Fenton, R. A., Aug 2017, In: American Journal of Physiology: Renal Physiology. 313, 2, p. F495-F504Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation
Rosenbaek, L. L., Rizzo, F., Wu, Q., Rojas-Vega, L., Gamba, G., MacAulay, Nanna, Staub, O. & Fenton, R. A., Dec 2017, In: Scientific Reports. 7, 15 p., 12981.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation
Stoica, A., Larsen, B. R., Assentoft, M., Holm, R., Holt, L. M., Vilhardt, Frederik, Vilsen, B., Lykke-Hartmann, K., Olsen, M. L. & MacAulay, Nanna, 2017, In: Glia. 65, 11, p. 1777-1793 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
Toft-Bertelsen, Trine Lisberg, Križaj, D. & MacAulay, Nanna, 1 Jun 2017, In: The Journal of Physiology. 595, 11, p. 3287-3302 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
Toft-Bertelsen, Trine Lisberg, Križaj, D. & MacAulay, Nanna, 2017, In: Journal of Physiology. 595, 11, p. 3287-3302 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Aquaporin 4 as a NH3 Channel
Assentoft, M., Kaptan, S., Schneider, H., Deitmer, J. W., de Groot, B. L. & MacAulay, Nanna, 2 Sep 2016, In: The Journal of Biological Chemistry. 291, 36, p. 19184-19195 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis
Landegren, N., Pourmousa Lindberg, M., Skov, J., Hallgren, Å., Eriksson, D., Lisberg Toft-Bertelsen, T., MacAulay, N., Hagforsen, E., Räisänen-Sokolowski, A., Saha, H., Nilsson, T., Nordmark, G., Ohlsson, S., Gustafsson, J., Husebye, E. S., Larsson, E., Anderson, M. S., Perheentupa, J., Rorsman, F., Fenton, R. A. & 1 others, , Oct 2016, In: Journal of the American Society of Nephrology:JASN. 27, 10, p. 3220-3228Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+ management during neuronal activity
Larsen, B. R., Holm, R., Vilsen, B. & MacAulay, Nanna, 15 Nov 2016, In: The Journal of Physiology. 594, 22, p. 6627-6641 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
Larsen, B. R., Stoica, A. & MacAulay, Nanna, 22 Apr 2016, In: Frontiers in Physiology. 7, 10 p., 141.Research output: Contribution to journal › Review › Research › peer-review
- Published
Regulation of the Water Channel Aquaporin-2 via 14-3-3 Theta (θ) and Zeta (ζ)
Møller, H. B., Slengerik-Hansen, J. E., Aroankins, T., Assentoft, M., MacAulay, Nanna, Moestrup, S. K., Bhalla, V. & Fenton, R. A., 29 Jan 2016, In: Journal of Biological Chemistry. 291, p. 2469-2484Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gβγ Signaling Regulates Aquaporin-2 Trafficking and Urinary Concentration
Olesen, Emma Tina Bisgaard, Poulsen, S. B., MacAulay, Nanna, Rieg, T. & Fenton, R. A., Apr 2016, In: F A S E B Journal. 30, S1Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway
Olesen, Emma Tina Bisgaard, Moeller, H. B., Assentoft, M., MacAulay, Nanna & Fenton, R. A., 1 Nov 2016, In: American Journal of Physiology: Renal Physiology. 311, 5, p. F935-F944 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A
Pedersen, K. L., Töllner, K., Feit, P. W., Erker, T., MacAulay, Nanna & Löscher, W., Jun 2016, In: Epilepsy & Behavior. 59, p. 42-49 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cl- channels in apoptosis
Wanitchakool, P., Ousingsawat, J., Sirianant, L., MacAulay, Nanna, Schreiber, R. & Kunzelmann, K., Oct 2016, In: European biophysics journal : EBJ. 45, 7, p. 599-610 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Isoform-specific phosphorylation-dependent regulation of connexin hemichannels
Alstrøm, J. S., Hansen, D. B., Nielsen, Morten Schak & MacAulay, Nanna, 15 Nov 2015, In: Journal of Neurophysiology. 114, 5, p. 3014-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels
Alstrøm, J. S., Stroemlund, L. W., Nielsen, Morten Schak & MacAulay, Nanna, Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 519-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PKC and AMPK regulation of Kv1.5 potassium channels
Andersen, M. N., Skibsbye, L., Tang, C., Petersen, F., MacAulay, Nanna, Rasmussen, Hanne Borger & Jespersen, Thomas, 2015, In: Channels (Austin). 9, 3, p. 121-8 8 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Gating of aquaporin 4-phosphorylation versus protonation
Assentoft, M., Kaptan, S., Fenton, R. A., Hua, S. Z., deGroot, B. L. & MacAulay, Nanna, Aug 2015, In: Glia. 63, S1, p. E446-E446 1 p., T15-05A .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Regulation and Function of AQP4 in the Central Nervous System
Assentoft, M., Larsen, B. R. & MacAulay, Nanna, Dec 2015, In: Neurochemical Research. 40, 12, p. 2615-2627 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia
Jo, A. O., Ryskamp, D. A., Phuong, T. T. T., Verkman, A. S., Yarishkin, O., MacAulay, Nanna & Križaj, D., 30 Sep 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 39, p. 13525-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Is H95 a pH-dependent gate in aquaporin 4?
Kaptan, S., Assentoft, M., Schneider, H. P., Fenton, R. A., Deitmer, J., MacAulay, Nanna & de Groot, B. L., 1 Dec 2015, In: Structure. 23, 12, p. 2309-2318 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate-induced astrocytic [Na+](i) elevation: a mechanism to increase K+ clearance via the Na+/K+-ATPase?
Larsen, B. R., Stoica, A., Holm, R., Vilsen, B. & MacAulay, Nanna, Aug 2015, In: Glia. 63, S1, p. E211-E212 2 p., T08-17A .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter
Pedersen, K. L., Töllner, K., Römermann, K., Feit, P. W., Erker, T., MacAulay, Nanna & Löscher, W., Sep 2015, In: British Journal of Pharmacology. 172, 18, p. 4464-4480 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vasopressin receptors V1a and V2 are not osmosensors
Pedersen, K. L., Assentoft, M., Fenton, R. A., Rosenkilde, Mette & MacAulay, Nanna, Aug 2015, In: Physiological Reports. 3, 8, 11 p., e12519.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading
Steffensen, Annette Buur, Sword, J., Croom, D., Kirov, S. A. & MacAulay, Nanna, 2 Sep 2015, In: Journal of Neuroscience. 35, 35, p. 12172-12187 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at COOH-terminal serine residues
Assentoft, M., Larsen, B. R., Olesen, Emma Tina Bisgaard, Fenton, R. A. & MacAulay, Nanna, 15 Nov 2014, In: American Journal of Physiology: Cell Physiology. 307, 10, p. C957-C965 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels
Hansen, D. B., Ye, Z., Callø, Kirstine, Braunstein, T. H., Hofgaard, J. P., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, 19 Sep 2014, In: The Journal of Biological Chemistry. 289, 38, p. 26058-73 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct permeation profiles of the connexin 30 and 43 hemichannels
Hansen, D. B., Braunstein, T. H., Nielsen, Morten Schak & MacAulay, Nanna, 17 Apr 2014, In: FEBS Letters. 588, 8, p. 1446-57 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses
Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kir4.1-mediated spatial buffering of K(+): Experimental challenges in determination of its temporal and quantitative contribution to K(+) clearance in the brain
Larsen, B. R. & MacAulay, Nanna, Oct 2014, In: Channels (Austin). 8, 6, p. 544-550 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia
Ryskamp, D. A., Jo, A. O., Frye, A. M., Vazquez-Chona, F., MacAulay, Nanna, Thoreson, W. B. & Križaj, D., 19 Nov 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 47, p. 15689-700 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Phosphorylation of rat aquaporin-4 at Ser(111) is not required for channel gating
Assentoft, M., Kaptan, S., Fenton, R. A., Hua, S. Z., de Groot, B. L. & MacAulay, Nanna, Jul 2013, In: Glia. 61, 7, p. 1101–1112 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1
Søgaard, R., Borre, L., Braunstein, T. H., Madsen, Kenneth Lindegaard & MacAulay, Nanna, 12 Jul 2013, In: The Journal of Biological Chemistry. 288, 28, p. 20195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Osmotic water transport in aquaporins: evidence for a stochastic mechanism
Zeuthen, Thomas, Alsterfjord, M., Beitz, E. & MacAulay, Nanna, 15 Oct 2013, In: Journal of Physiology. 591, Pt 20, p. 5017-29 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Glial K(+) Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps
MacAulay, Nanna & Zeuthen, Thomas, Nov 2012, In: Neurochemical Research. 37, 11, p. 2299-2309 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC
Rosenbaek, L. L., Assentoft, M., Pedersen, N. B., MacAulay, Nanna & Fenton, R. A., 1 Dec 2012, In: Journal of Physiology. 590, Pt 23, p. 6121-39 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevated ammonium levels: differential acute effects on three glutamate transporter isoforms
Søgaard, R., Novak, Ivana & MacAulay, Nanna, 2012, In: American Journal of Physiology: Cell Physiology. 302, 6, p. C880-C891 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cotransport of water by Na¿-K¿-2Cl¿ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2
Zeuthen, Thomas & MacAulay, Nanna, 1 Mar 2012, In: Journal of Physiology. 590, Pt 5, p. 1139-54 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Differential water permeability and regulation of three aquaporin 4 isoforms
Fenton, R. A., Moeller, H. B., Zelenina, M., Snaebjornsson, M. T., Holen, T. & MacAulay, Nanna, Mar 2010, In: Cellular and Molecular Life Sciences. 67, 5, p. 829-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Water transport between CNS compartments: contributions of aquaporins and cotransporters
MacAulay, Nanna & Zeuthen, Thomas, Jul 2010, In: Neuroscience. 168, 4, p. 941-56 15 p.Research output: Contribution to journal › Review › Research › peer-review
- 2009
- Published
Chloride transporters as water pumps: Elements in a new model of epithelial water transport: From Molecules to diseases
MacAulay, Nanna, Hamann, Steffen & Zeuthen, Thomas, 2009, Physiology and pathology of chloride transporters and channels in the nervous system. Alvarez-Leefmans, F. & Delpire, E. (eds.). Amsterdam, The Netherlands: Academic Press, p. 547-568 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1
Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes
Moeller, H. B., Fenton, R. A., Zeuthen, Thomas & MacAulay, Nanna, Dec 2009, In: Neuroscience. 164, 4, p. 1674-84 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating
Moeller, H. B., MacAulay, Nanna, Knepper, M. A. & Fenton, R. A., 2009, In: American Journal of Physiology - Renal Physiology. 296, 3, p. F649-57Research output: Contribution to journal › Journal article › Research › peer-review
ID: 10786
Most downloads
-
323
downloads
Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
Research output: Contribution to journal › Review › Research › peer-review
Published -
299
downloads
Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
206
downloads
Cotransporter-mediated water transport underlying cerebrospinal fluid formation
Research output: Contribution to journal › Journal article › Research › peer-review
Published