Claus Juul Løland

Claus Juul Løland

Professor

ORCID: 0000-0002-1773-1446

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  1. Published

    Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

    Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B. S., Shi, L., Loland, Claus Juul & Newman, A. H., Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter

    Zhang, P., Jørgensen, T. N., Loland, Claus Juul & Newman, A. H., 1 Jan 2013, In: Bioorg. Med. Chem. Lett.. 23, 1, p. 323-326 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

    Yoon, S., Bae, H. E., Hariharan, P., Nygaard, Andreas, Lan, B., Woubshete, M., Sadaf, A., Liu, X., Loland, Claus Juul, Byrne, B., Guan, L. & Chae, P. S., 2024, In: Bioconjugate Chemistry. 35, 2, p. 223–231 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT

    Topiol, S., Bang-Andersen, B., Sanchez, C., Plenge, P., Loland, Claus Juul, Juhl, K., Larsen, K., Bregnedal, P. & Bøgesø, K. P., 1 Feb 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 3, p. 470-478 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

    Targowska-Duda, K. M., Budzynska, B., Michalak, A., Wnorowski, A., Loland, Claus Juul, Maj, M., Manetti, D., Romanelli, M. N., Jozwiak, K., Biala, G. & Arias, H. R., 2021, In: European Neuropsychopharmacology. 52, p. 31-47 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

    Sørensen, G., Jensen, M., Weikop, Pia, Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

    Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The Environment Shapes the Inner Vestibule of LeuT

    Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

    Slack, R. D., Ku, T. C., Cao, J., Giancola, J. L. B., Bonifazi, A., Loland, Claus Juul, Gadiano, A., Lam, J., Rais, R., Slusher, B. S., Coggiano, M., Tanda, G. & Newman, A. H., 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2343-2357 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

    Simmons, K. J., Gotfryd, K., Billesbølle, C. B., Loland, Claus Juul, Gether, Ulrik, Fishwick, C. W. G. & Johnson, A. P., Mar 2013, In: Molecular Membrane Biology. 30, 2, p. 184-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

    Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, In: Plant Journal. 111, 4, p. 936-953 15866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, S. G., Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter: sodium symporter LeuT

    Schmidt, S. G., Nygaard, Andreas, Mindell, J. A. & Loland, Claus Juul, 2024, In: eLife. 12, 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

    Salomon, K., Abramyan, A. M., Plenge, P., Wang, L., Bundgaard, C., Bang-Andersen, B., Loland, Claus Juul & Shi, L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 41, 10 p., e2304089120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study

    Sadaf, A., Du, Y., Santillan, C., Mortensen, Jonas Sigurd, Molist, I., Seven, A. B., Hariharan, P., Skiniotis, G., Loland, Claus Juul, Kobilka, B. K., Guan, L., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 8, 12, p. 8315-8324 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study

    Sadaf, A., Mortensen, Jonas Sigurd, Capaldi, S., Tikhonova, E., Hariharan, P., de Castro Ribeiro, O., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1933-1939 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability

    Sadaf, A., Ramos, M., Mortensen, Jonas Sigurd, Du, Y., Bae, H. E., Munk, C. F., Hariharan, P., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 2019, In: ACS chemical biology. 14, 8, p. 1717-1726 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

    Sadaf, A., Kim, S., Bae, H. E., Wang, H., Nygaard, Andreas, Uegaki, Y., Du, Y., Munk, C. F., Katsube, S., Lee, H. S., Bae, J., Choi, C. W., Choi, H., Byrne, B., Gellman, S. H., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W. & Chae, P. S., 2021, In: Acta Biomaterialia. 128, p. 393-407 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

    Pugh, Ciara Frances, DeVree, B. T., Schmidt, S. G. & Loland, Claus Juul, 2022, In: Cells. 11, 23, 15 p., 3811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

    Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

    Plenge, P., Yang, D., Salomon, K., Laursen, L., Kalenderoglou, I. E., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2021, In: Nature Communications. 12, 1, 12 p., 5063.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    A Conserved Salt Bridge between Transmembrane Segment 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter

    Pedersen, A. V., Andreassen, T. F. & Loland, Claus Juul, 2014, In: Journal of Biological Chemistry. 289, 50, p. 35003-350014 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

    Okunola-Bakara, O., Cao, J., Kopajtic, T., Katz, J. L., Loland, Claus Juul, Shi, L. & Newman, A. H., 2014, In: Journal of Medicinal Chemistry. 57, 3, p. 1000-1013 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

    Okorom, A. V., Camacho-Hernandez, G. A., Salomon, Kristine Walløe, Lee, K. H., Ku, T. C., Cao, J., Won, S. J., Friedman, J., Lam, J., Paule, J., Rais, R., Klein, B., Xi, Z. X., Shi, L., Loland, Claus Juul & Newman, A. H., 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 709-727 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  32. Published

    Substrate-induced conformational dynamics of the dopamine transporter

    Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Persistent binding at dopamine transporters determines sustained psychostimulant effects

    Niello, M., Sideromenos, S., Gradisch, R., O'Shea, R., Schwazer, J., Maier, J., Kastner, N., Sandtner, W., Jäntsch, K., Lupica, C. R., Hoffman, A. F., Lubec, G., Loland, Claus Juul, Stockner, T., Pollak, D. D., Baumann, M. H. & Sitte, H. H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, 11 p., e2114204120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

    Niello, M., Gradisch, R., Loland, Claus Juul, Stockner, T. & Sitte, H. H., 2020, In: Trends in Pharmacological Sciences. 41, 7, p. 446-463 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

    Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Conformational dynamics of the human serotonin transporter during substrate and drug binding

    Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

    Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Short-Range Distance Measurement by Transition Metal Ion FRET

    Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  39. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contribution › Research

  41. Published

    Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

    MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters

    Loland, Claus Juul, Mar 2015, In: BBA General Subjects. 1850, 3, p. 500-510 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

    Loland, Claus Juul, Norregaard, L. & Gether, Ulrik, 1999, In: Journal of Biological Chemistry. 274, 52, p. 36928-34 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

    Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding

    Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters

    Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  47. Published

    Probing dopamine transporter structure and function y Zn2+ site engineering

    Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Neurotransmitter transporters: structure and function

    Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & Francis

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  50. Published

    Neurotransmitter Transporters: Structure, Function, and Drug Binding

    Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

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