Claus Juul Løland
Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
- 2018
- Published
A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability
Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation
Abramyan, A. M., Stolzenberg, S., Li, Z., Loland, Claus Juul, Noe, F. & Shi, L., 2017, In: A C S Chemical Neuroscience. 8, 8, p. 1735-1746 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region
Das, M., Du, Y., Mortensen, Jonas Sigurd, Ribeiro, O., Hariharan, P., Guan, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 2, p. 1169-1177 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties
Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, Jonas Sigurd, Patra, D., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Journal of the American Chemical Society. 139, 8, p. 3072-3081Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability
Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target
Loland, Claus Juul, Sanchez, C., Plenge, P., Bøgesø, K. P. & Bang-Andersen, B., 2017, Allosterism in Drug Discovery. Royal Society of Chemistry, p. 360-380 21 p. (RSC Drug Discovery Series; No. 56).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Neurotransmitter Transporters: Structure, Function, and Drug Binding
Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017Research output: Other contribution › Research
- Published
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study
Sadaf, A., Du, Y., Santillan, C., Mortensen, Jonas Sigurd, Molist, I., Seven, A. B., Hariharan, P., Skiniotis, G., Loland, Claus Juul, Kobilka, B. K., Guan, L., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 8, 12, p. 8315-8324 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT
Topiol, S., Bang-Andersen, B., Sanchez, C., Plenge, P., Loland, Claus Juul, Juhl, K., Larsen, K., Bregnedal, P. & Bøgesø, K. P., 1 Feb 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 3, p. 470-478 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders
Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B. S., Shi, L., Loland, Claus Juul & Newman, A. H., Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
Bae, H. E., Mortensen, Jonas Sigurd, Ribeiro, O., Du, Y., Ehsan, M., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Chae, P. S., 4 Oct 2016, In: Chemical communications (Cambridge, England). 52, 81, p. 12104-12107 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors
Cao, J., Slack, R. D., Bakare, O. M., Burzynski, C., Rais, R., Slusher, B. S., Kopajtic, T., Bonifazi, A., Ellenberger, M. P., Yano, H., He, Y., Bi, G., Xi, Z., Loland, Claus Juul & Newman, A. H., 8 Dec 2016, In: Journal of Medicinal Chemistry. 59, 23, p. 10676-10691 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length
Cho, K. H., Hariharan, P., Mortensen, Jonas Sigurd, Du, Y., Nielsen, A. K., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 14 Dec 2016, In: ChemBioChem. 17, 24, p. 2334–2339Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy
Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Markham, K., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 Dec 2016, In: Chemistry: A European Journal. 22, 52, p. 18833–18839Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies
Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, Jonas Sigurd, Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 Mar 2016, In: Journal of the American Chemical Society. 138, 11, p. 3789-3796 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
Hussain, H., Du, Y., Scull, N. J., Mortensen, Jonas Sigurd, Tarrasch, J., Bae, H. E., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 17 May 2016, In: Chemistry: A European Journal. 22, 21, p. 7068-7073 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Sadaf, A., Mortensen, Jonas Sigurd, Capaldi, S., Tikhonova, E., Hariharan, P., de Castro Ribeiro, O., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1933-1939 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4359
Most downloads
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799
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
224
downloads
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
195
downloads
A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Research output: Contribution to journal › Journal article › Research › peer-review
Published