The solute carrier 6 family of transporters
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The solute carrier 6 family of transporters. / Bröer, Stefan; Gether, Ulrik.
In: British Journal of Pharmacology, Vol. 167, No. 2, 22.08.2012, p. 256-78.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The solute carrier 6 family of transporters
AU - Bröer, Stefan
AU - Gether, Ulrik
N1 - © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
PY - 2012/8/22
Y1 - 2012/8/22
N2 - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.
AB - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.
KW - Amino Acid Sequence
KW - Animals
KW - Biological Transport
KW - Gene Expression Regulation
KW - Humans
KW - Membrane Transport Proteins
KW - Neurotransmitter Agents
KW - Protein Conformation
U2 - 10.1111/j.1476-5381.2012.01975.x
DO - 10.1111/j.1476-5381.2012.01975.x
M3 - Journal article
C2 - 22519513
VL - 167
SP - 256
EP - 278
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 2
ER -
ID: 47292735