Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

Research output: Contribution to journal › Journal article › Research › peer-review

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Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. / Weng, Feng-Ju; Garcia, Rodrigo I; Lutzu, Stefano; Alviña, Karina; Zhang, Yuxiang; Dushko, Margaret; Ku, Taeyun; Zemoura, Khaled; Rich, David; Garcia-Dominguez, Dario; Hung, Matthew; Yelhekar, Tushar D; Sørensen, Andreas Toft; Xu, Weifeng; Chung, Kwanghun; Castillo, Pablo E; Lin, Yingxi.

In: Neuron, Vol. 97, No. 5, 2018, p. 1137-1152.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Weng, F-J, Garcia, RI, Lutzu, S, Alviña, K, Zhang, Y, Dushko, M, Ku, T, Zemoura, K, Rich, D, Garcia-Dominguez, D, Hung, M, Yelhekar, TD, Sørensen, AT, Xu, W, Chung, K, Castillo, PE & Lin, Y 2018, 'Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation', Neuron, vol. 97, no. 5, pp. 1137-1152. https://doi.org/10.1016/j.neuron.2018.01.026

APA

Weng, F-J., Garcia, R. I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., Rich, D., Garcia-Dominguez, D., Hung, M., Yelhekar, T. D., Sørensen, A. T., Xu, W., Chung, K., Castillo, P. E., & Lin, Y. (2018). Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Neuron, 97(5), 1137-1152. https://doi.org/10.1016/j.neuron.2018.01.026

Vancouver

Weng F-J, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M et al. Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Neuron. 2018;97(5):1137-1152. https://doi.org/10.1016/j.neuron.2018.01.026

Author

Weng, Feng-Ju ; Garcia, Rodrigo I ; Lutzu, Stefano ; Alviña, Karina ; Zhang, Yuxiang ; Dushko, Margaret ; Ku, Taeyun ; Zemoura, Khaled ; Rich, David ; Garcia-Dominguez, Dario ; Hung, Matthew ; Yelhekar, Tushar D ; Sørensen, Andreas Toft ; Xu, Weifeng ; Chung, Kwanghun ; Castillo, Pablo E ; Lin, Yingxi. / Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. In: Neuron. 2018 ; Vol. 97, No. 5. pp. 1137-1152.

Bibtex

@article{ae009576d8d9407886e4e841d88c6158,

title = "Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation",

abstract = "Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons are essential for contextual memory encoding, but the molecular mechanisms regulating MF-CA3 synapses during memory formation and the exact nature of this regulation are poorly understood. Here we report that the activity-dependent transcription factor Npas4 selectively regulates the structure and strength of MF-CA3 synapses by restricting the number of their functional synaptic contacts without affecting the other synaptic inputs onto CA3 pyramidal neurons. Using an activity-dependent reporter, we identified CA3 pyramidal cells that were activated by contextual learning and found that MF inputs on these cells were selectively strengthened. Deletion of Npas4 prevented both contextual memory formation and this learning-induced synaptic modification. We further show that Npas4 regulates MF-CA3 synapses by controlling the expression of the polo-like kinase Plk2. Thus, Npas4 is a critical regulator of experience-dependent, structural, and functional plasticity at MF-CA3 synapses during contextual memory formation.",

keywords = "Journal Article",

author = "Feng-Ju Weng and Garcia, {Rodrigo I} and Stefano Lutzu and Karina Alvi{\~n}a and Yuxiang Zhang and Margaret Dushko and Taeyun Ku and Khaled Zemoura and David Rich and Dario Garcia-Dominguez and Matthew Hung and Yelhekar, {Tushar D} and S{\o}rensen, {Andreas Toft} and Weifeng Xu and Kwanghun Chung and Castillo, {Pablo E} and Yingxi Lin",

year = "2018",

doi = "10.1016/j.neuron.2018.01.026",

language = "English",

volume = "97",

pages = "1137--1152",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

AU - Weng, Feng-Ju

AU - Garcia, Rodrigo I

AU - Lutzu, Stefano

AU - Alviña, Karina

AU - Zhang, Yuxiang

AU - Dushko, Margaret

AU - Ku, Taeyun

AU - Zemoura, Khaled

AU - Rich, David

AU - Garcia-Dominguez, Dario

AU - Hung, Matthew

AU - Yelhekar, Tushar D

AU - Sørensen, Andreas Toft

AU - Xu, Weifeng

AU - Chung, Kwanghun

AU - Castillo, Pablo E

AU - Lin, Yingxi

PY - 2018

Y1 - 2018

N2 - Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons are essential for contextual memory encoding, but the molecular mechanisms regulating MF-CA3 synapses during memory formation and the exact nature of this regulation are poorly understood. Here we report that the activity-dependent transcription factor Npas4 selectively regulates the structure and strength of MF-CA3 synapses by restricting the number of their functional synaptic contacts without affecting the other synaptic inputs onto CA3 pyramidal neurons. Using an activity-dependent reporter, we identified CA3 pyramidal cells that were activated by contextual learning and found that MF inputs on these cells were selectively strengthened. Deletion of Npas4 prevented both contextual memory formation and this learning-induced synaptic modification. We further show that Npas4 regulates MF-CA3 synapses by controlling the expression of the polo-like kinase Plk2. Thus, Npas4 is a critical regulator of experience-dependent, structural, and functional plasticity at MF-CA3 synapses during contextual memory formation.

AB - Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons are essential for contextual memory encoding, but the molecular mechanisms regulating MF-CA3 synapses during memory formation and the exact nature of this regulation are poorly understood. Here we report that the activity-dependent transcription factor Npas4 selectively regulates the structure and strength of MF-CA3 synapses by restricting the number of their functional synaptic contacts without affecting the other synaptic inputs onto CA3 pyramidal neurons. Using an activity-dependent reporter, we identified CA3 pyramidal cells that were activated by contextual learning and found that MF inputs on these cells were selectively strengthened. Deletion of Npas4 prevented both contextual memory formation and this learning-induced synaptic modification. We further show that Npas4 regulates MF-CA3 synapses by controlling the expression of the polo-like kinase Plk2. Thus, Npas4 is a critical regulator of experience-dependent, structural, and functional plasticity at MF-CA3 synapses during contextual memory formation.

KW - Journal Article

U2 - 10.1016/j.neuron.2018.01.026

DO - 10.1016/j.neuron.2018.01.026

M3 - Journal article

C2 - 29429933

VL - 97

SP - 1137

EP - 1152

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -

ID: 189879227

Department of Neuroscience