Department of Neuroscience
The Panum Institute, room 24-4-42
Phone: +45 2860 4207
The main experimental approach of the laboratory has been the use and development of electrophysiological techniques in which the excitability and connectivity of spinal neurones can be investigated in transgenic rodent models in vivo.
The main experimental approach of the laboratory has been the use and development of electrophysiological techniques in which the excitability and connectivity of spinal neurones can be investigated in transgenic rodent models in vivo. Using this, we explore both normal spinal motor control and the role of changes in neuronal excitability in the pathophysiology of various injury and disease states affecting the motor system.
Amyotrophic Lateral Sclerosis. This is a neurodegenerative disease preferentially affecting upper and lower motor neurons with no current cure. The underlying pathophysiology of the disease is unclear but there is considerable evidence that neuronal excitability plays a role. Using transgenic models of the disease we are exploring the contributions of altered neuronal excitability to the degeneration of the motoneurons.
Spinal cord injury. Spinal cord trauma results not only in the loss of functions controlled by the spinal cord below the injury, but also gains of function. These can serious impair quality of life and include chronic pain, autonomic dysfunction and spasticity. We are exploring the plasticity of neuronal excitability and circuitry following spinal cord injury that underlie these phenomena.
Plasticity of excitable domains of axons: We are interested in plasticity of the action potential generating region of motoneurons- the axon initial segment along with the nodes of Ranvier where action potentials are renewed. We have shown these to be highly plastic structures on spinal motoneurons and are trying to investigate the role that this plays in various injury and disease states.
Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis Legat.