MacAulay Lab

The research group focuses on elucidation of the molecular mechanisms underlying water and ion homeostasis in the mammalian brain under both physiological and pathophysiological conditions.

Nanna MacAulay info

News

 

Traumatic brain injury and brain hemorrhage can lead to the brain water accumulation called hydrocephalus. The subsequent elevation in brain pressure can be fatal if left untreated. But we do not know how and why it happens and we have no efficient pharmacological treatment.

We are excited to share the molecular coupling between brain bleeding and brain water accumulation – either on verse here or on BioRxiv (find link in commentaries below). We hope this first stepping stone can bring us closer to medical treatment of this condition.  

Congratulations to Trine for her accomplishment with this study and thanks to all our collaborators. The generous funding from LBF and NNF is highly appreciated

 

 

To manage intracranial pressure in pathology, we must understand brain fluid dynamics in physiology

Scenes from the BrainH2O conference

Finally – a F2F conference!

Thanks to all the participants at the BrainH2O symposium in Copenhagen this past week. It was wonderful to see colleagues and friends from around the world again – and to share the science that we envision will help diagnose and treat the patients with disturbed brain fluid balance.

Thanks to the Novo Nordic Foundation and the graduate school at SUND for their support.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Nanna MacAulay(2021) Molecular mechanisms of brain water transport. Nature Reviews Neuroscience 6:326-344
  • Trine Lisberg Toft-Bertelsen, Brian Roland Larsen, Sofie Kjellerup Christensen, Himanshu Khandelia, Helle S. Waagepetersen & Nanna MacAulay (2020) Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4; A study with an isoform-selective AQP4 inhibitor.GLIA 69: 28-41
  • Lykke K, Assentoft M, Hørlyck S, Helms HCC, Stoica A, Toft-Bertelsen TL, Tritsaris K, Vilhardt F, Brodin B & MacAulay N (2019) Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter (NKCC1) in electrolyte fluxes in an in vitro BBB model of dehydration. Journal of Cerebral Blood Flow and Metabolism 39: 497-512
  • Eva Kjer Oernbo, Kasper Lykke, Annette B. Steffensen, Kathrin Töllner, Christina Kruuse, Martin Fredensborg Rath, Wolfgang Löscher & Nanna MacAulay (2018) Cerebral influx of Na+ and Cl- as the osmotherapy-mediated rebound response in rats. Fluids and Barriers in the CNS 15:27
  • Steffensen AB, Oernbo EK, Stoica S, Gerkau NJ, Barbuskaite D, Tritsaris K, Rose CR & MacAulay N (2018) Cotransporter-mediated water transport underlying cerebrospinal fluid formation. Nature Communications 9:2167
  • Larsen BR & MacAulay N (2017) Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms. GLIA 65:1668-1681
  • Toft-Bertelsen TL, Krízaj D & MacAulay N (2017) When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor. Journal of Physiology 595:3287-3302
  • Steffensen AB, Sword J, Croom D, Kirov SA & MacAulay N (2015) Cotransporters as a molecular mechanism underlying spreading depolarization-induced dendritic beading. Journal of Neuroscience 35:12172-12187
  • Larsen BR, Assentoft A, Cotrina ML, Hua SZ, Nedergaard M, Kaila K, Voipio J & MacAulay N (2014) Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+-clearance and volume responses. GLIA 62:608-622

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2021

84. Sara Diana Lolansen, Nina Rostgaard, Søren Norge Andreassen, Anja Hviid Simonsen, Marianne Juhler, Steen Gregers Hasselbalch and Nanna MacAulay (2021) Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus. Fluids and Barriers of CNS, accepted for publication

83. Monica Lakk, GF Hoffmann, A. Gorusupudi, E Enyong, A Lin, PS Bernstein, Trine L. Toft-Bertelsen, Nanna MacAulay, MH Elliott, David Križaj (2021) Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension. Journal of Lipid Research:100145, online ahead of print

82. Trine L. Toft-Bertelsen & Nanna MacAulay (2021) TRPing on Cell Swelling - TRPV4 Senses It.  Frontiers of Immunology 12:730982

81. Nanna MacAulay (2021) Reply to ‘Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis’. Nature Reviews Neuroscience 10:651-652

80. Nanna MacAulay(2021) Molecular mechanisms of brain water transport. Nature Reviews Neuroscience 6:326-344

79. Sara D. Lolansen, Nina Rostgaard, Eva Kjer Oernbo, Marianne Juhler, Anja Hviid Simonsen & Nanna MacAulay (2021). Inflammatory markers in cerebrospinal fluid from patients with hydrocephalus: a systematic literature review. Disease Markers 8834822. doi: 10.1155/2021/8834822

78. Trine L. Toft-Bertelsen & Nanna MacAulay (2021) TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel. Cells 10:165. doi: 10.3390/cells10010165

2020

77. G.V. Mkrtchyan, K. Abdelmohsen, P. Andreux et al. (2020) ARDD 2020: from aging mechanisms to interventions. Aging 12:24484-24503

76. Nanna MacAulay & Christine C. Rose (2020) Rebuttal from Nanna MacAulay and Christine C. Rose. Journal of Physiology 598:4743

75. Nanna MacAulay & Christine C. Rose (2020) CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion. Journal of Physiology 598: 4737-4739

74. Trine Lisberg Toft-Bertelsen, Brian Roland Larsen, Sofie Kjellerup Christensen, Himanshu Khandelia, Helle S. Waagepetersen & Nanna MacAulay (2020) Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4; A study with an isoform-selective AQP4 inhibitor. GLIA 69: 28-41

73. Nanna MacAulay (2020) Molecular mechanisms of K+ clearance and extracellular space shrinkage-Glia cells as the stars. GLIA 68:2192-2211

72. Brian Skriver Nielsen, Trine Lisberg Toft-Bertelsen, Sara D. Lolansen, Connor L. Anderson, Morten Schak Nielsen, Roger J. Thompson & Nanna MacAulay (2020) Pannexin 1 activation and inhibition is permeant-selective. Journal of Physiology 598:361-379

2019

71. Trine Lisberg Toft-Bertelsen, Oleg Yarishkin, Sara Redmon,Tam TT Phuong, David Krizaj & Nanna MacAulay (2019) Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminus volume-sensing domain. Journal of Biological Chemistry 294:18421-18434

70. Brian Skriver Nielsen, Francesco Zonta, Thomas Farkas, Thomas Litman, Morten Schak Nielsen & Nanna MacAulay (2019) Structural determinants underlying permeant discrimination of the Cx43 hemichannel. Journal of Biological Chemistry 294:16789-16803

69. Kasper Lykke, Mette Assentoft, Sofie Hørlyck, Hans Christian C. Helms, Anca Stoica, Trine L. Toft-Bertelsen, Katerina Tritsaris, Frederik Vilhardt, Birger Brodin & Nanna MacAulay (2019) Evaluating the involvement of cerebralmicrovascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter (NKCC1) in electrolyte fluxes in an in vitro BBB model of dehydration. Journal of Cerebral Blood Flow and Metabolism 39: 497-512.

68. Brian Roland Larsen, Anca Stoica, Nanna MacAulay (2019) Developmental maturation of activity-induced K+and pH transients and the associated extracellular space dynamics in the rat hippocampus. Journal of Physiology, 597: 583-597

2018

67. Claudia Brandt, P Seja, Katrin Töllner, Kerstin Römermann, Philip Hampel, M Kalesse, A Kipper, Peter W Feit, Kasper Lykke, Trine L Toft-Bertelsen, P Paavilainen, I Spoljaric, Martin Puskarjov , Nanna MacAulay, Kai Kaila, Wolfgang Löscher (2018) Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy. Neuropharmacology 143:186-204

66. Eva Kjer Oernbo, Kasper Lykke, Annette B. Steffensen, Kathrin Töllner, Christina Kruuse, Martin Fredensborg Rath, Wolfgang Löscher & Nanna MacAulay (2018) Cerebral influx of Na+ and Cl- as the osmotherapy-mediated rebound response in rats. Fluids and Barriers in the CNS 15:27

65. Philip Hampel, Kerstin Römermann, Nanna MacAulay, Wolfgang Löscher (2018) Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Scientific Reports 8:9877

64. Annette B. Steffensen, Eva K. Oernbo, Anca Stoica, Niklas J. Gerkau, Dagne Barbuskaite, Katerina Tritsaris, Christine R. Rose & Nanna MacAulay (2018) Cotransporter-mediated water transport underlying cerebrospinal fluid formation. Nature Communications 9:2167

63. Katja Stahl, S. Rahmani, A. Prydz, N. Skauli, Nanna MacAulay, M.N. Mylonakou, R. Torp, Ø. Skare, T. Berg, T.B. Leergaard, R.E. Paulsen, O.P. Ottersen, Mahmood Amiry-Moghaddam (2018) Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One 13:e0194896

62. Trine L. Toft-Bertelsen, Brian Roland Larsen & Nanna MacAulay (2018) Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? Channels 12;100-108

61. Siren Berland, Trine L. Toft-Bertelsen, Ingvild Aukrust, Jan Byska, Marc Vaudel, Laurence A. Bindoff, Nanna MacAulay (shared senior authorship) & Gunnar Houge (2018) A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. Molecular Case Studies 4(1), pii: a002303

2017

60. Brian Skriver Nielsen, Jette Skov Alstrom,Bruce J. Nicholson, Morten Schak Nielsen & Nanna MacAulay (2017) Permeant-specific gating of connexin 30 hemichannels. Journal of Biological Chemistry 292:19999-20009

59. Lena Rosenbaek, Federica Rizzo, Qi Wu, Lorena Rojas-Vega, Gerardo Gamba Ayala, Nanna MacAulay, Oliver Staub & Robert A. Fenton (2017) The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation. Scientific
Reports 7(1):12981

58. Anca Stoica, Brian Roland Larsen, Mette Assentoft, Rikke Holm, Leanne M. Holt, Frederik Vilhardt, Bente Vilsen, Karin Lykke-Hartmann, Michelle L. Olsen & Nanna MacAulay (2017) The α2β2 isoform combination dominates the astrocytic Na+ /K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. GLIA 65:1777-1793

57. Brian Roland Larsen & Nanna MacAulay (2017) Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms. GLIA 65:1668-1681

56. Lena L. Rosenbaek. F. Rizzo, Nanna MacAulay, Olivier Staub & Robert A. Fenton (2017) Functional Assessment of Sodium Chloride Co-transporter NCC Mutants in Polarized Mammalian Epithelial Cells. American Journal of Physiology - Renal Physiology 313:F495-F504

55.  Brian s. Nielsen, Daniel B. Hansen, Bruce R. Ransom, Morten S. Nielsen & Nanna MacAulay (2017) Connexin hemichannels in astrocytes: An assessment of controversies regarding their functional characteristics. Neurochemical
Research 42:2537-2550

54.  Trine L. Toft-Bertelsen, David Krízaj & Nanna MacAulay (2017) When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor. Journal of Physiology 595:3287-3302

2016

53. Emma Olesen, Hanne Moeller, Mette Assentoft, Nanna MacAulay & Robert Fenton (2016) The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway. American Journal of Physiology – Renal Physiology 311:935-944

52. Mette Assentoft, Shreyas Kaptan, Hans-Peter Schneider, Joachim W. Deitmer, Bert L. de Groot & Nanna MacAulay (2016) Aquaporin 4 as a NH3 channel. Journal of Biological Chemistry 291:19184-19195

51. P. Wanitchakool, J. Ousingsawat, L. Sirianant, Nanna MacAulay, Rainer Schreiber & Karl Kunzelmann (2016) Cl- channels in apoptosis. European Biophysical Journal 45: 599-610

50. Brian Roland Larsen, Rikke Holm, Bente Vilsen & Nanna MacAulay (2016) Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+ management during neuronal activity. Journal of Physiology 594:6627-6641      

49. Brian Roland Larsen, Anca Stoica & Nanna MacAulay (2016) Managing brain extracellular K+ during neuronal activity: The physiological role of the Na+/K+-ATPase subunit isoforms. Frontiers of Physiology 7(141), fphys.2016.00141

48. Kasper Lykke, Kathrin Töllner, Peter W. Feit, Thomas Erker, Nanna MacAulay & Wolfgang Löscher (2016) The search for NKCC1-selective drugs: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Epilepsy & Behavior 59:42-49

47. Nils Landegren, M. Pourmousa Lindberg, J. Skov, Å. Hallgren, D. Eriksson, Trine Lisberg Toft-Bertelsen, Nanna MacAulay, E. Hagforsen, A. Räisänen-Sokolowski, H. Saha, T. Nilsson, G. Nordmark, S. Ohlsson, J. Gustafsson, E.S. Husebye, E. Larsson, M.S. Anderson, J. Perheentupa, F. Rorsman, Robert A. Fenton & O. Kämpe (2016) Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis. Journal of American Society of Nephrology 27:3220-3228

46. Hanne B. Moeller, J. Slengerik-Hansen, T. Aroankins, Mette Assentoft, Nanna MacAulay, Søren K. Moestrup, V. Bhalla & Fenton RA (2016) Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ. Journal of Biological Chemistry 291:2469-84

2015

45. Andrew Jo, Daniel A. Ryskamp, Tam T.T. Phuong, Alan S. Verkman, Oleg YarishkinNanna MacAulay & David Križaj (2015). TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal Müller glia. Journal of Neuroscience 35:13525-13537

44. Shreyas Kaptan, Mette Assentoft, Hans Peter Schneider, Robert A. Fenton, Joachim Deitmer, Nanna MacAulay & Bert de Groot (2015) Is H95 a pH-dependent gate in aquaporin 4? Structure 23:2309-2318

43. Jette S. Alstrom, Daniel B. Hansen, Morten S. Nielsen & Nanna MacAulay (2015) Isoform-specific phosphorylation-dependent regulation of connexin hemichannels. Journal of Neurophysiology 14:3014-22

42. Annette B. Steffensen, Jeremy Sword, Deborah Croom, Sergei A. Kirov & Nanna MacAulay (2015) Cotransporters as a molecular mechanism underlying spreading depolarization-induced dendritic beading. Journal of Neuroscience 35:12172-12187

41. Kasper Lykke, Mette Assentoft, Robert A. Fenton, Mette M. Rosenkilde & Nanna MacAulay (2015). Vasopressin receptors V1a and V2 are not osmo-sensors. Physiological Reports 3(8), phy2.12519

40. Kasper Lykke, Kathrin Töllner, Kerstin Römermann, Peter W. Feit, Thomas Erker, Nanna MacAulay & Wolfgang Löscher (2015) Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of human NKCC2 variant A. British Journal of Pharmacology, bph.13231

39. Mette Assentoft, Brian Roland Larsen & Nanna MacAulay (2015) Regulation and Function of AQP4 in the Central Nervous System. Neurochemical Research 40:2615-2627

38. Martin N. Andersen, Lasse Skibsbye, C. Tang, F. Petersen, Nanna MacAulay, Hanne B. Rasmussen & Thomas Jespersen (2015) PKC and AMPK regulation of Kv1.5 potassium channels. Channels 9:121-8

37. Jette S. Alstrom, Line W. Stroemlund, Morten S. Nielsen & Nanna MacAulay (2015) Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels. Biochemical Society Transaction 43:519-23

36. Daniel Ryskamp, Andrew Jo, Amber Frye, Felix Vazquez-Chona, Nanna MacAulay, Wallace Thoreson, and David Krizaj (2015) Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia. Journal of Neuroscience 34:15689-15700

2014

35. Brian Roland Larsen & Nanna MacAulay (2014) Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+ clearance in the brain. Channels 8:544-560

34. Mette Assentoft, Brian Roland Larsen, Emma T.B. Olesen, Robert A. Fenton & Nanna MacAulay (2014) AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at C-terminal serine residues. American Journal of Physiology – Cell Physiology 307:957-965

33. Daniel Bloch Hansen, Ye Zu-Cheng, Kirstine Calloe, Thomas H. Braunstein, Johannes P. Hofgaard, Bruce R. Ransom, Morten S. Nielsen & Nanna MacAulay (2014) Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels. Journal of Biological Chemistry 289:26058-26073

32. Daniel Bloch Hansen, Thomas H. Braunstein, Morten S. Nielsen & Nanna MacAulay (2014) Distinct permeation profiles of the connexin 30 and 43 hemichannels. FEBS Letters 588:1446-1457

31. Brian Roland Larsen, Mette Assentoft, Maria L. Cotrina, Susan Z. Hua, Maiken Nedergaard, Kai Kaila, Juha Voipio & Nanna MacAulay (2014) Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+-clearance and volume responses. GLIA 62:608-622

2013

30. Thomas Zeuthen, Magnus Alsterfjord, Eric Beitz & Nanna MacAulay (2013) Osmotic water transport in aquaporins. Evidence for a stochastic mechanism. Journal of Physiology 591:5017-5029

29. Rikke Sogaard, Lars Borre, Thomas H.  Braunstein, Kenneth L. Madsen & Nanna MacAulay (2013) Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1. Journal of Biological Chemistry 288:20195-20207

28. Mette Assentoft, Shreyas Kaptan, Robert A. Fenton, Susan Z. Hua, Bert L. de Groot & Nanna MacAulay (2013) Phosphorylation of rat aquaporin-4 at Ser111 is not required for channel gating. GLIA 61: 1101-1112

2012

27. Lene L. Rosenbaek, Mette Assentoft, Nis B. Pedersen, Nanna MacAulay & Robert A. Fenton (2012) Characterization of a novel phosphorylations site in the sodium chloride transporter, NCC. Journal of Physiology 590:6121-6139

26. Nanna MacAulay & Thomas Zeuthen (2012) Glial K+ clearance and cell swelling: key roles for cotransporters and pumps. Neurochemical Research 37: 2299-2309

25. Thomas Zeuthen & Nanna MacAulay (2012) Transport of water against its concentration gradient: fact or fiction? WIREs Membrane Transport Signaling 1: 373-381 (doi:10.1002/wmts:54)

24. Thomas Zeuthen & Nanna MacAulay (2012) Cotransport of water by the Na+-K+-2Cl- cotransporter expressed in Xenopus oocytes: NKCC1 versus NKCC2. Journal of Physiology 590: 1139-1154

23. Rikke Søgaard, Ivana Novak & Nanna MacAulay (2012) Differential effect of ammonia on three glutamate transporter isoforms expressed in Xenopus oocytes. American Journal of Physiology – Cell Physiology, 302:880-891

2010

22. Robert A. Fenton, Hanne B. Moeller, Marina Zelenina, Marteinn T. Snaebjornsson, Torgeir Holen & Nanna MacAulay (2010) Differential water permeability and regulation of three AQP4 isoforms. Cellular and Molecular Life Sciences. 67:829-840

21. Nanna MacAulay & Thomas Zeuthen (2010) Water transport between CNS compartments: contribution of aquaporins versus co-transporters. Neuroscience 168:941-956

2009

20. Hanne B. Moeller, Robert A. Fenton, Thomas Zeuthen & Nanna MacAulay (2009) Vasopressin-dependent short-term regulation of AQP4 expressed in Xenopus oocytes. Neuroscience 164:1674-1684

19. Nanna MacAulay, Steffen Hamann & Thomas Zeuthen (2009) Chloride transporters as water pumps: Elements in a new model of epithelial water transport. In: Physiology and pathology of chloride transporters and channels in the nervous system. Eds FJ Alvarez-Leefmans & E Delpire. Academic Press, Elsevier pp 547-568

18. Rikke Soe, Nanna MacAulay & Dan Klaerke (2009) Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. Neurosci. Lett. 457, 80-84

17. Anne-Kristine Meinild, Don D. Loo, Søren Skovstrup, Ulrik Gether & Nanna MacAulay (2009) Elucidating conformational changes in the gamma-aminobutyric acid (GABA)-transporter-1. J. Biol. Chem. 284:16226-15235

16. Rikke Søgaard, Magnus Alsterfjord, Nanna MacAulay & Thomas Zeuthen (2009) Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH. Pflugers Arch., 458: 733-743

15. Hanne B Moeller, Nanna MacAulay (shared first author), Mark A Knepper & Robert A Fenton (2009) Role of multiple phosphorylation sites in the carboxyl-terminal tail of aquaporin-2 for water transport: Evidence against channel gating. Am. J. Physiol. Renal Physiol.296, F649-657

2007

14. Thomas Zeuthen, Emil Zeuthen & Nanna MacAulay (2007) Water transport by GLUT2 expressed in Xenopus laevis oocytes. J. Physiol. 579, 345-361

2005

13. Aidas Alaburda, Raul Russo, Nanna MacAulay & Jørn Hounsgaard (2005) Periodic High and Low Conductance States in Spinal Motoneurons and Interneurons during Scratch-like Network Activity in Adult Turtles. J. Neuroscience 25, 6316-21

2004

12. Nanna MacAulay, Steffen Hamann & Thomas Zeuthen (2004) Water Transport in the Brain: Role of Cotransporters. Neuroscience 129, 1031-1044

2003

11. Nanna MacAulay, Anne-Kristine Meinild, Thomas Zeuthen & Ulrik Gether (2003) Residues in the Extracellular Loop 4 are Critical for Maintaining the Conformational Equilibrium of the g-Aminobutyric Acid (GABA) Transporter-1. J. Biol. Chem 278, 28771-28777

10. Morten Grunnet, Thomas Jespersen, Nanna MacAulay, Nanna K. Jørgensen, Nicole Schmitt, Olaf Pongs, Søren-Peter Olesen & Dan Klærke (2003) KCNQ1 Channels Sense Small Changes in Cell Volume. J. Physiol. 549, 419-427

2002

9. Nanna MacAulay, Thomas Zeuthen & Ulrik Gether (2002) Conformational Basis for the Li+-Induced Leak Current in the rat g-Aminobutyric Acid (GABA) Transporter-1. J. Physiol. 544, 447-458

8. Nanna MacAulay, Ulrik Gether, Dan Klærke & Thomas Zeuthen (2002) Passive Water and Urea Permeability of a Human Na+/Glutamate Cotransporter expressed in Xenopus oocytes. J. Physiol. 542, 817-828

7. Morten Grunnet, Nanna MacAulay, Nanna K. Jørgensen, Bo S. Jensen, Søren-Peter Olesen & Dan Klærke (2002) Regulation of Cloned Ca2+-activated K+ Channels by Cell Volume Changes. Pflugers Arch. 444, 167-177

6. Thomas Zeuthen & Nanna MacAulay (2002) Passive Water Transport in Biological Pores. In International Review of Cytology, vol 215, eds T. Zeuthen & W.D. Stein., pp 259-284. Academic Press, San Diego.

5. Thomas Zeuthen & Nanna MacAulay (2002) Cotransporters as Molecular Water Pumps. In International Review of Cytology, vol 215, eds T. Zeuthen & W.D. Stein., pp 203-230. Academic Press, San Diego.

2001

4. Nanna MacAulay, Annie Bendahan, Claus Juul Loland, Thomas Zeuthen, Baruch I.Kanner  & Ulrik Gether (2001) Engineered Zn2+ Switches in the GABA Transporter-1: Differential Effects on GABA Uptake and Currents. J. Biol. Chem. 276, 40476-40485

3. Nanna MacAulay, Ulrik Gether, Dan Klærke & Thomas Zeuthen (2001) Water Transport by the Na+-coupled Glutamate Cotransporter Expressed in Xenopus Oocytes.  J.Physiol. 530, 367-378

1998

2. Rhoda Blostein, Stewart E. Daly, Nanna Boxenbaum, Lois K. Lane, José M. Arguello, Jerry B. Lingrel, Steve J. D. Karlish & Michael J. Caplan (1998) Conformational Alterations Resulting from Mutations in Cytoplasmic Domains of the Alpha Subunit of the Na,K-ATPase. Acta Physiol. Scand. (Suppl.) 643, 275-281

1. Nanna Boxenbaum, Stewart E. Daly, Zahid Z. Javaid, Lois K. Lane & Rhoda Blostein (1998) Changes in Steady-state Conformational Equilibrium Resulting from Cytoplasmic Mutations of the Na,K-ATPase α-Subunit. J. Biol. Chem. 273, 23086-23092

 

 

 

 

 

Lab members

Name Title Job responsibilities Image
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Annette Buur Steffensen Assistant Professor MacAulay lab Billede af Annette Buur Steffensen
Beatriche Louise Edelbo Henriksen PhD Fellow MacAulay Lab Billede af Beatriche Louise Edelbo Henriksen
Dagne Barbuskaite Postdoc MacAulay lab Billede af Dagne Barbuskaite
Dennis Bo Jensen Postdoc Billede af Dennis Bo Jensen
Joachim Birch Milan Guest Researcher MacAulay lab Billede af Joachim Birch Milan
Jonathan Henry Wardman Assistant Professor MacAulay Lab Billede af Jonathan Henry Wardman
Mette Nyholm Jensen Master-Student MacAulay Lab Billede af Mette Nyholm Jensen
Nanna MacAulay Professor MacAulay Lab Billede af Nanna MacAulay
Nina Rostgaard Guest Researcher MacAulay lab Billede af Nina Rostgaard
Sara Diana Lolansen PhD Fellow MacAulay Lab Billede af Sara Diana Lolansen
Søren Norge Andreassen PhD Student MacAulay lab Billede af Søren Norge Andreassen
Thomas Zeuthen Professor Emeritus MacAulay Lab Billede af Thomas Zeuthen
Trine Lind Devantier Laboratory Coordinator MacAulay Lab Billede af Trine Lind Devantier
Trine Lisberg Toft Assistant Professor MacAulay lab Billede af Trine Lisberg Toft