Katsuhiko Mikoshiba
Shanghai Tech University
“IP3R/Ca2+ channel at ER in physiological and pathophysiological condition ”
Abstract:Mikoshiba established a novel concept of endoplasmic reticulum (ER)-resident IP3R/channel which he discovered from the ataxic mice cerebellum: He established that it is a calcium oscillator and plays a role in development and brain function. It is a causal gene for human spinocerebellar ataxia 15/16 29, Gillespie Syndrome, ataxic cerebral palsy, pontocerebellar hypoplasia, and human exocrine secretion (sweat) deficit. It is a calcium channel with huge (1,252 kDa) signaling hub for disease-associated molecules (chaperones, anti-/pro-apoptotic proteins, huntingtin, ataxin, caspase 3). It is a key integrator for sensing ER stress and apoptotic stress response to protect from degenerative disorders. He developed a STAND (ultra-stable cytoplasmic antibody) technology engineered for in vivo applications applicable to rescue COVID-19, cancer and neurodegenerative disorders.