Bric, University of Copenhagen
Maturation of inhibitory neurons and its impairment in neurodevelopmental disorders
The majority of inhibitory neurons are generated during embryonic neurogenesis. Impairments in migration and differentiation of inhibitory neurons will result in disorganization of inhibitory networks and dysfunction of local circuits thus contributing to a cognitive disorder. We investigated how positioning, differentiation and transcriptome of inhibitory neurons are affected in several mouse models of psychiatric disorders and in human patients.