Nanna MacAulay
Professor
Molecular Neuroscience
Blegdamsvej 3
2200 København N.
- Published
When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
Toft-Bertelsen, Trine Lisberg, Križaj, D. & MacAulay, Nanna, 2017, In: Journal of Physiology. 595, 11, p. 3287-3302 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
Toft-Bertelsen, Trine Lisberg, Križaj, D. & MacAulay, Nanna, 1 Jun 2017, In: The Journal of Physiology. 595, 11, p. 3287-3302 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Water transport in brain: Role of cotransporters
MacAulay, Nanna, Hamann, S. & Zeuthen, Thomas, 2004, In: Neuroscience. 129, 4, p. 1031-1044Research output: Contribution to journal › Journal article › Research › peer-review
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Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In: Journal of Physiology. 530 (Pt 3), p. 367-378Research output: Contribution to journal › Journal article › Research › peer-review
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Water transport by GLUT2 expressed in Xenopus laevis oocytes
Zeuthen, Thomas, Zeuthen, E. & MacAulay, Nanna, 2007, In: Journal of Physiology. 579, 2, p. 345-361 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Water transport between CNS compartments: contributions of aquaporins and cotransporters
MacAulay, Nanna & Zeuthen, Thomas, Jul 2010, In: Neuroscience. 168, 4, p. 941-56 15 p.Research output: Contribution to journal › Review › Research › peer-review
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Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain
Toft-Bertelsen, Trine Lisberg, Yarishkin, O., Redmon, S., Phuong, T. T. T., Krizaj, D. & MacAulay, Nanna, 2019, In: Journal of Biological Chemistry. 294, 48, p. 18421-18434 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus
Rostgaard, Nina, Olsen, M. H., Lolansen, Sara Diana, Nørager, N. H., Plomgaard, Peter Stendahl, MacAulay, Nanna & Juhler, Marianne, 2023, In: Acta Neurochirurgica. 165, p. 4059–4070 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes
Moeller, H. B., Fenton, R. A., Zeuthen, Thomas & MacAulay, Nanna, Dec 2009, In: Neuroscience. 164, 4, p. 1674-84 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vasopressin receptors V1a and V2 are not osmosensors
Pedersen, K. L., Assentoft, M., Fenton, R. A., Rosenkilde, Mette & MacAulay, Nanna, Aug 2015, In: Physiological Reports. 3, 8, 11 p., e12519.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus
Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Villadsen, René & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 44.Research output: Contribution to journal › Journal article › Research › peer-review
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Toward New AQP4 Inhibitors: ORI-TRN-002
Thormann, M., Traube, N., Yehia, N., Koestler, R., Galabova, G., MacAulay, Nanna & Toft-Bertelsen, Trine Lisberg, 2024, In: International Journal of Molecular Sciences. 25, 2, 11 p., 924.Research output: Contribution to journal › Journal article › Research › peer-review
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The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation
Stoica, A., Larsen, B. R., Assentoft, M., Holm, R., Holt, L. M., Vilhardt, Frederik, Vilsen, B., Lykke-Hartmann, K., Olsen, M. L. & MacAulay, Nanna, 2017, In: Glia. 65, 11, p. 1777-1793 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation
Rosenbaek, L. L., Rizzo, F., Wu, Q., Rojas-Vega, L., Gamba, G., MacAulay, Nanna, Staub, O. & Fenton, R. A., Dec 2017, In: Scientific Reports. 7, 15 p., 12981.Research output: Contribution to journal › Journal article › Research › peer-review
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The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A
Pedersen, K. L., Töllner, K., Feit, P. W., Erker, T., MacAulay, Nanna & Löscher, W., Jun 2016, In: Epilepsy & Behavior. 59, p. 42-49 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway
Olesen, Emma Tina Bisgaard, Moeller, H. B., Assentoft, M., MacAulay, Nanna & Fenton, R. A., 1 Nov 2016, In: American Journal of Physiology: Renal Physiology. 311, 5, p. F935-F944 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion
Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson’s disease
Stahl, K., Rahmani, S., Prydz, A., Skauli, N., MacAulay, Nanna, Mylonakou, M. N., Torp, R., Skare, Ø., Berg, T., Leergaard, T. B., Paulsen, R. E., Ottersen, O. P. & Amiry-Moghaddam, M., 2018, In: PLOS ONE. 13, 3, e0194896.Research output: Contribution to journal › Journal article › Research › peer-review
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TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Toft-Bertelsen, Trine Lisberg & MacAulay, Nanna, 2021, In: Cells. 10, 1, 16 p., 165.Research output: Contribution to journal › Review › Research › peer-review
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TRPing on Cell Swelling-TRPV4 Senses It
Toft-Bertelsen, Trine Lisberg & MacAulay, Nanna, 2021, In: Frontiers in Immunology. 12, 9 p., 730982.Research output: Contribution to journal › Review › Research › peer-review
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TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia
Jo, A. O., Ryskamp, D. A., Phuong, T. T. T., Verkman, A. S., Yarishkin, O., MacAulay, Nanna & Križaj, D., 30 Sep 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 39, p. 13525-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia
Ryskamp, D. A., Jo, A. O., Frye, A. M., Vazquez-Chona, F., MacAulay, Nanna, Thoreson, W. B. & Križaj, D., 19 Nov 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 47, p. 15689-700 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter
Pedersen, K. L., Töllner, K., Römermann, K., Feit, P. W., Erker, T., MacAulay, Nanna & Löscher, W., Sep 2015, In: British Journal of Pharmacology. 172, 18, p. 4464-4480 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural determinants underlying permeant discrimination of the Cx43 hemichannel
Nielsen, B. S., Zonta, F., Farkas, T., Litman, Thomas, Nielsen, Morten Schak & MacAulay, Nanna, 2019, In: Journal of Biological Chemistry. 294, 45, p. 16789-16803 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spontaneously hypertensive rats can become hydrocephalic despite undisturbed secretion and drainage of cerebrospinal fluid
Lolansen, Sara Diana, Barbuskaite, Dagne, Ye, F., Xiang, J., Keep, R. F. & MacAulay, Nanna, 2023, In: Fluids and Barriers of the CNS. 20, 1, 11 p., 53.Research output: Contribution to journal › Journal article › Research › peer-review
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Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?
Toft-Bertelsen, Trine Lisberg, Larsen, B. R. & MacAulay, Nanna, 2018, In: Channels (Austin). 12, 1, p. 100-108Research output: Contribution to journal › Review › Research › peer-review
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Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating
Moeller, H. B., MacAulay, Nanna, Knepper, M. A. & Fenton, R. A., 2009, In: American Journal of Physiology - Renal Physiology. 296, 3, p. F649-57Research output: Contribution to journal › Journal article › Research › peer-review
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Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.
MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to 'Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis'
MacAulay, Nanna, 2021, In: Nature Reviews Neuroscience. 22, p. 651–652Research output: Contribution to journal › Letter › Research › peer-review
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Regulation of the Water Channel Aquaporin-2 via 14-3-3 Theta (θ) and Zeta (ζ)
Møller, H. B., Slengerik-Hansen, J. E., Aroankins, T., Assentoft, M., MacAulay, Nanna, Moestrup, S. K., Bhalla, V. & Fenton, R. A., 29 Jan 2016, In: Journal of Biological Chemistry. 291, p. 2469-2484Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.
Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation and Function of AQP4 in the Central Nervous System
Assentoft, M., Larsen, B. R. & MacAulay, Nanna, Dec 2015, In: Neurochemical Research. 40, 12, p. 2615-2627 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rebuttal from Nanna MacAulay and Christine R. Rose
MacAulay, Nanna & Rose, C. R., 2020, In: Journal of Physiology. 598, 21, p. 4743 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels
Alstrøm, J. S., Stroemlund, L. W., Nielsen, Morten Schak & MacAulay, Nanna, Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 519-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.Research output: Contribution to journal › Journal article › Research › peer-review
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Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality
Lolansen, Sara Diana, Rostgaard, Nina, Capion, T., Norager, N. H., Olsen, M. H., Juhler, Marianne, Mathiesen, Tiit Illimar & MacAulay, Nanna, 2023, In: International Journal of Molecular Sciences. 24, 14, 13 p., 11476.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of rat aquaporin-4 at Ser(111) is not required for channel gating
Assentoft, M., Kaptan, S., Fenton, R. A., Hua, S. Z., de Groot, B. L. & MacAulay, Nanna, Jul 2013, In: Glia. 61, 7, p. 1101–1112 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Permeant-specific gating of connexin 30 hemichannels
Nielsen, B. S., Alstrom, J. S., Nicholson, B., Nielsen, Morten Schak & MacAulay, Nanna, 2017, In: Journal of Biological Chemistry. 292, 49, p. 19999-20009Research output: Contribution to journal › Journal article › Research › peer-review
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Periodic high conductance states in spinal neurons during scratch-like network activity in adult turtles
Alaburda, A., Russo, R., MacAulay, Nanna & Hounsgaard, Jørn Dybkjær, 2005, In: Journal of Neuroscience. 25, p. 6316-6321Research output: Contribution to journal › Journal article › Research › peer-review
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Passive water transport in biological pores
Zeuthen, Thomas & MacAulay, Nanna, 2002, In: International Review of Cytology. 215, p. 203-230Research output: Contribution to journal › Journal article › Research › peer-review
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Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pannexin 1 activation and inhibition is permeant-selective
Nielsen, B. S., Toft-Bertelsen, Trine Lisberg, Lolansen, Sara Diana, Anderson, C. L., Nielsen, Morten Schak, Thompson, R. J. & MacAulay, Nanna, 2020, In: The Journal of Physiology. 598, 2, p. 361-379 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Paediatric hydrocephalus
Kahle, K. T., Klinge, P. M., Koschnitzky, J. E., Kulkarni, A. V., MacAulay, Nanna, Robinson, S., Schiff, S. J. & Strahle, J. M., 2024, In: Nature Reviews Disease Primers. 10, 1, 16 p., 35.Research output: Contribution to journal › Journal article › Research › peer-review
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PKC and AMPK regulation of Kv1.5 potassium channels
Andersen, M. N., Skibsbye, L., Tang, C., Petersen, F., MacAulay, Nanna, Rasmussen, Hanne Borger & Jespersen, Thomas, 2015, In: Channels (Austin). 9, 3, p. 121-8 8 p.Research output: Contribution to journal › Letter › Research › peer-review
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Osmotic water transport in aquaporins: evidence for a stochastic mechanism
Zeuthen, Thomas, Alsterfjord, M., Beitz, E. & MacAulay, Nanna, 15 Oct 2013, In: Journal of Physiology. 591, Pt 20, p. 5017-29 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure
Steffensen, Annette Buur, Edelbo, Beatriche Louise, Barbuskaite, Dagne, Andreassen, Søren Norge, Olsen, M. H., Møller, Kirsten & MacAulay, Nanna, 2023, In: Fluids and Barriers of the CNS. 20, 1, 14 p., 49.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanisms of brain water transport
MacAulay, Nanna, 2021, In: Nature Reviews Neuroscience. 22, p. 326–344 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Molecular mechanisms of brain water transport
MacAulay, Nanna, 2020, University of Copenhagen. 222 p.Research output: Book/Report › Doctoral thesis › Research
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Molecular mechanisms of K+ clearance and extracellular space shrinkage—Glia cells as the stars
MacAulay, Nanna, 2020, In: Glia. 68, 11, p. 2192-2211 20 p.Research output: Contribution to journal › Review › Research › peer-review
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Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume
Soe, R., MacAulay, Nanna & Klærke, Dan Arne, Jun 2009, In: Neuroscience Letters. 457, 2, p. 80-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production
Wardman, Jonathan Henry, Jensen, Mette Nyholm, Andreassen, Søren Norge, Styrishave, Bjarne, Wilhjelm, J. E., Sinclair, A. J. & MacAulay, Nanna, 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 44.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
Oernbo, E. K., Steffensen, Annette Buur, Khamesi, P. R., Toft-Bertelsen, Trine Lisberg, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, N. J., Tritsaris, Katerina, Simonsen, A. H., Lolansen, Sara Diana, Andreassen, Søren Norge, Hasselbalch, Steen, Zeuthen, Thomas, Rose, C. R., Kurtcuoglu, V. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
Lakk, M., Hoffmann, G. F., Gorusupudi, A., Enyong, E., Lin, A., Bernstein, P. S., Toft-Bertelsen, Trine Lisberg, MacAulay, Nanna, Elliott, M. H. & Krizaj, D., 2021, In: Journal of Lipid Research. 62, 15 p., 100145.Research output: Contribution to journal › Journal article › Research › peer-review
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Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
Larsen, B. R., Stoica, A. & MacAulay, Nanna, 22 Apr 2016, In: Frontiers in Physiology. 7, 10 p., 141.Research output: Contribution to journal › Review › Research › peer-review
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Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1
Toft-Bertelsen, Trine Lisberg, Barbuskaite, Dagne, Heerfordt, E. K., Lolansen, Sara Diana, Andreassen, Søren Norge, Rostgaard, Nina, Olsen, M. H., Norager, N. H., Capion, T., Rath, Martin Fredensborg, Juhler, Marianne & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p., 69.Research output: Contribution to journal › Journal article › Research › peer-review
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Kir4.1-mediated spatial buffering of K(+): Experimental challenges in determination of its temporal and quantitative contribution to K(+) clearance in the brain
Larsen, B. R. & MacAulay, Nanna, Oct 2014, In: Channels (Austin). 8, 6, p. 544-550 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KCNQ1 channels sense small changes in cell volume.
Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isoform-specific phosphorylation-dependent regulation of connexin hemichannels
Alstrøm, J. S., Hansen, D. B., Nielsen, Morten Schak & MacAulay, Nanna, 15 Nov 2015, In: Journal of Neurophysiology. 114, 5, p. 3014-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is H95 a pH-dependent gate in aquaporin 4?
Kaptan, S., Assentoft, M., Schneider, H. P., Fenton, R. A., Deitmer, J., MacAulay, Nanna & de Groot, B. L., 1 Dec 2015, In: Structure. 23, 12, p. 2309-2318 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Involvement of Aquaporin-1 in brain water homeostasis
Rasmussen, Dennis Bo, Barbuskaite, Dagne & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, Supplement 1, p. 25 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review
Lolansen, Sara Diana, Rostgaard, N., Oernbo, E. K., Juhler, Marianne, Simonsen, A. H. & MacAulay, Nanna, 2021, In: Disease Markers. 2021, 12 p., 8834822.Research output: Contribution to journal › Review › Research › peer-review
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Inflammatory Markers as Predictors of Shunt Dependency and Functional Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage
Rostgaard, Nina, Olsen, M. H., Capion, T., MacAulay, Nanna & Juhler, Marianne, 2023, In: Biomedicines. 11, 4, 14 p., 997.Research output: Contribution to journal › Journal article › Research › peer-review
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Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research
Juhler, Marianne, Hansen, T. S., Novrup, H. V. G., MacAulay, Nanna & Munch, Tina Nørgaard, 2022, In: World Neurosurgery. 161, p. 424-431 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gβγ Signaling Regulates Aquaporin-2 Trafficking and Urinary Concentration
Olesen, Emma Tina Bisgaard, Poulsen, S. B., MacAulay, Nanna, Rieg, T. & Fenton, R. A., Apr 2016, In: F A S E B Journal. 30, S1Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Glutamate-induced astrocytic [Na+](i) elevation: a mechanism to increase K+ clearance via the Na+/K+-ATPase?
Larsen, B. R., Stoica, A., Holm, R., Vilsen, B. & MacAulay, Nanna, Aug 2015, In: Glia. 63, S1, p. E211-E212 2 p., T08-17A .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+ management during neuronal activity
Larsen, B. R., Holm, R., Vilsen, B. & MacAulay, Nanna, 15 Nov 2016, In: The Journal of Physiology. 594, 22, p. 6627-6641 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glial K(+) Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps
MacAulay, Nanna & Zeuthen, Thomas, Nov 2012, In: Neurochemical Research. 37, 11, p. 2299-2309 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Gating of aquaporin 4-phosphorylation versus protonation
Assentoft, M., Kaptan, S., Fenton, R. A., Hua, S. Z., deGroot, B. L. & MacAulay, Nanna, Aug 2015, In: Glia. 63, S1, p. E446-E446 1 p., T15-05A .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1
Søgaard, R., Borre, L., Braunstein, T. H., Madsen, Kenneth Lindegaard & MacAulay, Nanna, 12 Jul 2013, In: The Journal of Biological Chemistry. 288, 28, p. 20195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells
Rosenbaek, L. L., Rizzo, F., MacAulay, Nanna, Staub, O. & Fenton, R. A., Aug 2017, In: American Journal of Physiology: Renal Physiology. 313, 2, p. F495-F504Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
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Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents
MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1
Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated ammonium levels: differential acute effects on three glutamate transporter isoforms
Søgaard, R., Novak, Ivana & MacAulay, Nanna, 2012, In: American Journal of Physiology: Cell Physiology. 302, 6, p. C880-C891 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus
Lolansen, Sara Diana, Rostgaard, Nina, Andreassen, Søren Norge, Simonsen, A. H., Juhler, Marianne, Hasselbalch, Steen & MacAulay, Nanna, 2021, In: Fluids and Barriers of the CNS. 18, 1, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis
MacAulay, Nanna & Toft-Bertelsen, Trine Lisberg, 2023, In: Cell Calcium. 116, 9 p., 102797.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct permeation profiles of the connexin 30 and 43 hemichannels
Hansen, D. B., Braunstein, T. H., Nielsen, Morten Schak & MacAulay, Nanna, 17 Apr 2014, In: FEBS Letters. 588, 8, p. 1446-57 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus
Toft-Bertelsen, Trine Lisberg, Andreassen, Søren Norge, Rostgaard, Nina, Olsen, M. H., Norager, N. H., Capion, T., Juhler, Marianne & MacAulay, Nanna, 2023, In: Biomedicines. 11, 9, 14 p., 2360.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential water permeability and regulation of three aquaporin 4 isoforms
Fenton, R. A., Moeller, H. B., Zelenina, M., Snaebjornsson, M. T., Holen, T. & MacAulay, Nanna, Mar 2010, In: Cellular and Molecular Life Sciences. 67, 5, p. 829-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential proteomic profile of lumbar and ventricular cerebrospinal fluid
Rostgaard, Nina, Olsen, M. H., Ottenheijm, Maud Eline, Drici, L., Simonsen, A. H., Plomgaard, Peter Stendahl, Gredal, Hanne Birgit, Poulsen, Helle Harding, Zetterberg, H., Blennow, K., Hasselbalch, Steen, MacAulay, Nanna & Juhler, Marianne, 2023, In: Fluids and Barriers of the CNS. 20, 1, 13 p., 6.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developmental maturation of activity-induced K+ and pH transients and the associated extracellular space dynamics in the rat hippocampus
Larsen, B. R., Stoica, A. & MacAulay, Nanna, 2019, In: Journal of Physiology. 597, 2, p. 583-597Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Day–night fluctuations in choroid plexus transcriptomics and cerebrospinal fluid metabolomics
Edelbo, Beatriche Louise, Andreassen, Søren Norge, Steffensen, Annette Buur & MacAulay, Nanna, 2023, In: PNAS Nexus. 2, 8, 10 p., pgad262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DRAIN - Double-blind Randomized Acetazolamide trial in Idiopathic Normal pressure hydrocephalus
Virhammar, J., Braun, M., Ekblom, M., Fasth, O., Fallmar, D., Laurell, K., MacAulay, Nanna & Nyholm, D., 2022, In: Fluids and Barriers of the CNS. 19, Supplement 1, p. 10 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion
MacAulay, Nanna & Rose, C. R., 2020, In: Journal of Physiology. 598, 21, p. 4737-4739 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Cotransporters as molecular water pumps
Zeuthen, Thomas & MacAulay, Nanna, 2002, In: International Review of Cytology. 215, p. 259-84 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cotransporter-mediated water transport underlying cerebrospinal fluid formation
Steffensen, Annette Buur, Oernbo, E. K., Stoica, A., Gerkau, N. J., Barbuskaite, Dagne, Tritsaris, Katerina, Rose, C. R. & MacAulay, Nanna, 2018, In: Nature Communications. 9, 1, 13 p., 2167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cotransport of water by Na¿-K¿-2Cl¿ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2
Zeuthen, Thomas & MacAulay, Nanna, 1 Mar 2012, In: Journal of Physiology. 590, Pt 5, p. 1139-54 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses
Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics
Nielsen, B. S., Hansen, D. B., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, Sep 2017, In: Neurochemical Research. 42, 9, p. 2537–2550 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 2002, In: Journal of Physiology. 544, 2, p. 447-458Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase
Blostein, R., Daly, S. E., MacAulay, Nanna, Lane, L. K., Arguello, J. M., Lingrel, J. B., Karlish, S. J., Caplan, M. J. & Dunbar, L., 1998, In: Acta Physiologica Scandinavica. Supplementum. 643, p. 275-81 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform-selective AQP4 inhibitor
Toft-Bertelsen, Trine Lisberg, Larsen, B. R., Christensen, S. K., Khandelia, H., Waagepetersen, Helle S. & MacAulay, Nanna, 2020, In: Glia. 69, 1, p. 28-41 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cl- channels in apoptosis
Wanitchakool, P., Ousingsawat, J., Sirianant, L., MacAulay, Nanna, Schreiber, R. & Kunzelmann, K., Oct 2016, In: European biophysics journal : EBJ. 45, 7, p. 599-610 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chloride transporters as water pumps: Elements in a new model of epithelial water transport: From Molecules to diseases
MacAulay, Nanna, Hamann, Steffen & Zeuthen, Thomas, 2009, Physiology and pathology of chloride transporters and channels in the nervous system. Alvarez-Leefmans, F. & Delpire, E. (eds.). Amsterdam, The Netherlands: Academic Press, p. 547-568 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading
Steffensen, Annette Buur, Sword, J., Croom, D., Kirov, S. A. & MacAulay, Nanna, 2 Sep 2015, In: Journal of Neuroscience. 35, 35, p. 12172-12187 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC
Rosenbaek, L. L., Assentoft, M., Pedersen, N. B., MacAulay, Nanna & Fenton, R. A., 1 Dec 2012, In: Journal of Physiology. 590, Pt 23, p. 6121-39 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in steady-state conformational equilibrium resulting from cytoplasmic mutations of tha Na,K-ATPase a subunit
MacAulay, Nanna, Daly E., S., Javaid Z., Z., Lane K., L. & Blostein, R., 1998, In: Journal of Biological Chemistry. 273, p. 23086-23092Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
MacAulay, Nanna, Keep, R. F. & Zeuthen, Thomas, 2022, In: Fluids and Barriers of the CNS. 19, 1, 18 p., 26.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cerebrospinal fluid osmolality cannot predict development or surgical outcome of idiopathic normal pressure hydrocephalus
Ørnbo, E. K., Steffensen, Annette Buur, Gredal, Hanne Birgit, Poulsen, Helle Harding, Rostgaard, Nina, Rasmussen, C. H., Møller-Nissen, M., Simonsen, A. H., Hasselbalch, Steen, Juhler, Marianne & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 9 p., 52.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cerebral influx of Na+ and Cl- as the osmotherapy-mediated rebound response in rats
Oernbo, E. K., Lykke, K., Steffensen, Annette Buur, Töllner, K., Kruuse, Christina Rostrup, Rath, Martin Fredensborg, Löscher, W. & MacAulay, Nanna, 2018, In: Fluids and Barriers of the CNS. 15, 14 p., 27.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review
Ben-Shoshan, Shai David, Lolansen, Sara Diana, Mathiesen, Tiit Illimar & MacAulay, Nanna, 2023, In: Acta Neurochirurgica. 165, p. 3271-3287 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension
Wardman, Jonathan Henry, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Jensen, Mette Nyholm, Wilhjelm, J. E., Styrishave, Bjarne, Hamann, Steffen, Heegaard, Steffen, Sinclair, A. J. & MacAulay, Nanna, 2024, In: Fluids and Barriers of the CNS. 21, 1, 20 p., 10.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy: [Inkl. Corrigendum]
Brandt, C., Seja, P., Töllner, K., Römermann, K., Hampel, P., Kalesse, M., Kipper, A., Feit, P. W., Lykke, K., Toft-Bertelsen, Trine Lisberg, Paavilainen, P., Spoljaric, I., Puskarjov, M., MacAulay, Nanna, Kaila, K. & Löscher, W., 2018, In: Neuropharmacology. 143, p. 186-204 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
Hampel, P., Römermann, K., MacAulay, Nanna & Löscher, W., 2018, In: Scientific Reports. 8, 11 p., 9877.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis
Landegren, N., Pourmousa Lindberg, M., Skov, J., Hallgren, Å., Eriksson, D., Lisberg Toft-Bertelsen, T., MacAulay, N., Hagforsen, E., Räisänen-Sokolowski, A., Saha, H., Nilsson, T., Nordmark, G., Ohlsson, S., Gustafsson, J., Husebye, E. S., Larsson, E., Anderson, M. S., Perheentupa, J., Rorsman, F., Fenton, R. A. & 1 others, , Oct 2016, In: Journal of the American Society of Nephrology:JASN. 27, 10, p. 3220-3228Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic connexin hemichannels are regulated by PKC phosphorylation in an isoform-specific manner
MacAulay, Nanna, Alstrom, J. S., Hansen, D. B. & Nielsen, Morten Schak, 2017, In: Glia. 65, S1, p. E64-E64 S17-01.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis
Razzaghi Khamesi, P., Charitatos, V., Heerfordt, E. K., MacAulay, Nanna & Kurtcuoglu, V., 2023, In: Fluids and Barriers of the CNS. 20, 1, 13 p., 18.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aquaporin 4 as a NH3 Channel
Assentoft, M., Kaptan, S., Schneider, H., Deitmer, J. W., de Groot, B. L. & MacAulay, Nanna, 2 Sep 2016, In: The Journal of Biological Chemistry. 291, 36, p. 19184-19195 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH
Søgaard, R., Alsterfjord, M., MacAulay, Nanna & Zeuthen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 733-43 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms
Larsen, B. R. & MacAulay, Nanna, Oct 2017, In: Glia. 65, 10, p. 1668-1681 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels
Hansen, D. B., Ye, Z., Callø, Kirstine, Braunstein, T. H., Hofgaard, J. P., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, 19 Sep 2014, In: The Journal of Biological Chemistry. 289, 38, p. 26058-73 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus
Barbuskaite, Dagne, Ørnbo, E. K., Wardman, Jonathan Henry, Toft-Bertelsen, Trine Lisberg, Conti, E., Andreassen, Søren Norge, Gerkau, N. J., Rose, C. R. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, p. 53 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration
Westgate, C. S. J., Kamp-Jensen, C., Israelsen, I. M. E., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C. A., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rigmor Højland & Eftekhari, S., 2024, In: British Journal of Pharmacology. 181, 1, p. 70-86Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at COOH-terminal serine residues
Assentoft, M., Larsen, B. R., Olesen, Emma Tina Bisgaard, Fenton, R. A. & MacAulay, Nanna, 15 Nov 2014, In: American Journal of Physiology: Cell Physiology. 307, 10, p. C957-C965 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance
Berland, S., Toft-Bertelsen, Trine Lisberg, Aukrust, I., Byska, J., Vaudel, M., Bindoff, L. A., MacAulay, Nanna & Houge, G., 2018, In: Cold Spring Harbor molecular case studies. 4, 1, 10 p., a002303.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 10786
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Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
Research output: Contribution to journal › Review › Research › peer-review
Published -
301
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Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
208
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Cotransporter-mediated water transport underlying cerebrospinal fluid formation
Research output: Contribution to journal › Journal article › Research › peer-review
Published