Tenna Bering, Rath Lab

Circadian oscillators of the cerebral cortex and cerebellum: evidence of roles and regulation from studies in rodent models

We have investigated the physiological and molecular effects of genetic disruptions in the molecular clock in the cerebral cortex and the cerebellum, respectively. Furthermore, a possible hormonal signaling pathway from the central clock in the suprachiasmaticus nucleus to the circadian oscillators in the cerebral cortex and cerebellum is evaluated using programmable micropumps with corticosterone infused in a rhythm mimicking normal circadian fluctuations.