Eva Maria Carlsen, Perrier Lab

Spinal astrocytes control pathological tremor via CB1 receptors

Abstract: Activation of cannabinoid receptors can reduce tremor associated with motor disorders induced by injuries and neurodegenerative diseases. However, the underlying biological system responsible for this effect is still unidentified. We discovered the existence of an intrinsic spinal mechanism that regulates pathological tremor and we found that the activation of CB1 receptors expressed in spinal astrocytes is responsible for the anti-tremor effect produced by cannabinoids. Thus, our data indicate that spinal astrocytes can act as an anti-tremor filter.

NB. This seminar will be held in the Nielsine Nielsen Auditorium.