Vasopressin binds to microvessels from rat hippocampus.
Research output: Contribution to journal › Journal article › Research › peer-review
Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.
Original language | English |
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Journal | Brain Research |
Volume | 380 |
Issue number | 2 |
Pages (from-to) | 325-30 |
Number of pages | 5 |
ISSN | 0006-8993 |
Publication status | Published - 1986 |
Externally published | Yes |
ID: 14942369