Vasopressin binds to microvessels from rat hippocampus.
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Vasopressin binds to microvessels from rat hippocampus. / Kretzschmar, R; Landgraf, R; Gjedde, A; Ermisch, A.
In: Brain Research, Vol. 380, No. 2, 1986, p. 325-30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Vasopressin binds to microvessels from rat hippocampus.
AU - Kretzschmar, R
AU - Landgraf, R
AU - Gjedde, A
AU - Ermisch, A
PY - 1986
Y1 - 1986
N2 - Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.
AB - Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.
M3 - Journal article
C2 - 3756483
VL - 380
SP - 325
EP - 330
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -
ID: 14942369