The structure and function of G-protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
Original language | English |
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Journal | Nature |
Volume | 459 |
Issue number | 7245 |
Pages (from-to) | 356-63 |
Number of pages | 8 |
ISSN | 0028-0836 |
DOIs | |
Publication status | Published - 21 May 2009 |
- Animals, Conserved Sequence, Cytoplasm, Humans, Opsins, Protein Conformation, Receptors, G-Protein-Coupled, Signal Transduction
Research areas
ID: 120588589