The structure and function of G-protein-coupled receptors

Research output: Contribution to journal › Journal article › Research › peer-review

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The structure and function of G-protein-coupled receptors. / Rosenbaum, Daniel M; Rasmussen, Søren Gøgsig Faarup; Kobilka, Brian K.

In: Nature, Vol. 459, No. 7245, 21.05.2009, p. 356-63.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rosenbaum, DM, Rasmussen, SGF & Kobilka, BK 2009, 'The structure and function of G-protein-coupled receptors', Nature, vol. 459, no. 7245, pp. 356-63. https://doi.org/10.1038/nature08144

APA

Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009). The structure and function of G-protein-coupled receptors. Nature, 459(7245), 356-63. https://doi.org/10.1038/nature08144

Vancouver

Rosenbaum DM, Rasmussen SGF, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356-63. https://doi.org/10.1038/nature08144

Author

Rosenbaum, Daniel M ; Rasmussen, Søren Gøgsig Faarup ; Kobilka, Brian K. / The structure and function of G-protein-coupled receptors. In: Nature. 2009 ; Vol. 459, No. 7245. pp. 356-63.

Bibtex

@article{5e207d42324b464f85f4e28891bdce0d,
title = "The structure and function of G-protein-coupled receptors",
abstract = "G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.",
keywords = "Animals, Conserved Sequence, Cytoplasm, Humans, Opsins, Protein Conformation, Receptors, G-Protein-Coupled, Signal Transduction",
author = "Rosenbaum, {Daniel M} and Rasmussen, {S{\o}ren G{\o}gsig Faarup} and Kobilka, {Brian K}",
year = "2009",
month = may,
day = "21",
doi = "10.1038/nature08144",
language = "English",
volume = "459",
pages = "356--63",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7245",

}

RIS

TY - JOUR

T1 - The structure and function of G-protein-coupled receptors

AU - Rosenbaum, Daniel M

AU - Rasmussen, Søren Gøgsig Faarup

AU - Kobilka, Brian K

PY - 2009/5/21

Y1 - 2009/5/21

N2 - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

AB - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

KW - Animals

KW - Conserved Sequence

KW - Cytoplasm

KW - Humans

KW - Opsins

KW - Protein Conformation

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

U2 - 10.1038/nature08144

DO - 10.1038/nature08144

M3 - Journal article

C2 - 19458711

VL - 459

SP - 356

EP - 363

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7245

ER -

ID: 120588589