TY - JOUR

T1 - Membrane Binding and Modulation of the PDZ Domain of PICK1

AU - Erlendsson, Simon

AU - Madsen, Kenneth Lindegaard

PY - 2015/12

Y1 - 2015/12

N2 - Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.

AB - Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.

KW - PDZ domains

KW - lipid-binding domains

KW - PICK1

KW - scaffolding proteins

U2 - 10.3390/membranes5040597

DO - 10.3390/membranes5040597

M3 - Review

C2 - 26501328

VL - 5

SP - 597

EP - 615

JO - Membranes

JF - Membranes

SN - 2077-0375

IS - 4

ER -