In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation. / Metuh, Pietro; Meneghetti, Marcello; Berg, Rune W.; Markos, Christos.

In: Optical Fiber Technology, Vol. 82, 103632, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Metuh, P, Meneghetti, M, Berg, RW & Markos, C 2024, 'In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation', Optical Fiber Technology, vol. 82, 103632. https://doi.org/10.1016/j.yofte.2023.103632

APA

Metuh, P., Meneghetti, M., Berg, R. W., & Markos, C. (2024). In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation. Optical Fiber Technology, 82, [103632]. https://doi.org/10.1016/j.yofte.2023.103632

Vancouver

Metuh P, Meneghetti M, Berg RW, Markos C. In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation. Optical Fiber Technology. 2024;82. 103632. https://doi.org/10.1016/j.yofte.2023.103632

Author

Metuh, Pietro ; Meneghetti, Marcello ; Berg, Rune W. ; Markos, Christos. / In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation. In: Optical Fiber Technology. 2024 ; Vol. 82.

Bibtex

@article{eda2e877a4f0469a929763bf428b463b,
title = "In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation",
abstract = "Optical neural interfaces combining optogenetics and electrophysiology have been demonstrated as powerful tools for distinguishing the causal roles of neural circuits in the nervous system. Functional optrodes for multipoint stimulation and recording have already been demonstrated in the brain. However, soft and flexible multimodal optrodes for the purpose of probing the spinal cord have remained undeveloped. Here, we present the design and fabrication of a novel optrode for multi-site optical stimulation and electrical recording in the spinal cord by combining optical fiber drawing of polymer material, laser micromachining, and integration of tungsten microelectrodes in a monolithic fiber-based structure. The results from space-resolved scattering measurements, electrochemical impedance spectroscopy, and an acute in vivo electrophysiology experiment in an anesthetized rodent suggest this probe as a potential novel interface, which can serve as a part of therapeutic strategies against neurological conditions and injury in the spinal cord.",
author = "Pietro Metuh and Marcello Meneghetti and Berg, {Rune W.} and Christos Markos",
year = "2024",
doi = "10.1016/j.yofte.2023.103632",
language = "English",
volume = "82",
journal = "Optical Fiber Technology",
issn = "1068-5200",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation

AU - Metuh, Pietro

AU - Meneghetti, Marcello

AU - Berg, Rune W.

AU - Markos, Christos

PY - 2024

Y1 - 2024

N2 - Optical neural interfaces combining optogenetics and electrophysiology have been demonstrated as powerful tools for distinguishing the causal roles of neural circuits in the nervous system. Functional optrodes for multipoint stimulation and recording have already been demonstrated in the brain. However, soft and flexible multimodal optrodes for the purpose of probing the spinal cord have remained undeveloped. Here, we present the design and fabrication of a novel optrode for multi-site optical stimulation and electrical recording in the spinal cord by combining optical fiber drawing of polymer material, laser micromachining, and integration of tungsten microelectrodes in a monolithic fiber-based structure. The results from space-resolved scattering measurements, electrochemical impedance spectroscopy, and an acute in vivo electrophysiology experiment in an anesthetized rodent suggest this probe as a potential novel interface, which can serve as a part of therapeutic strategies against neurological conditions and injury in the spinal cord.

AB - Optical neural interfaces combining optogenetics and electrophysiology have been demonstrated as powerful tools for distinguishing the causal roles of neural circuits in the nervous system. Functional optrodes for multipoint stimulation and recording have already been demonstrated in the brain. However, soft and flexible multimodal optrodes for the purpose of probing the spinal cord have remained undeveloped. Here, we present the design and fabrication of a novel optrode for multi-site optical stimulation and electrical recording in the spinal cord by combining optical fiber drawing of polymer material, laser micromachining, and integration of tungsten microelectrodes in a monolithic fiber-based structure. The results from space-resolved scattering measurements, electrochemical impedance spectroscopy, and an acute in vivo electrophysiology experiment in an anesthetized rodent suggest this probe as a potential novel interface, which can serve as a part of therapeutic strategies against neurological conditions and injury in the spinal cord.

U2 - 10.1016/j.yofte.2023.103632

DO - 10.1016/j.yofte.2023.103632

M3 - Journal article

VL - 82

JO - Optical Fiber Technology

JF - Optical Fiber Technology

SN - 1068-5200

M1 - 103632

ER -

ID: 379869388