Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Research output: Contribution to journalJournal articleResearchpeer-review

  • Haohao Wu
  • Charles Petitpré
  • Paula Fontanet
  • Anil Sharma
  • Bellardita, Carmelo
  • Rolen M Quadros
  • Paulo R Jannig
  • Yiqiao Wang
  • J Alexander Heimel
  • Kylie K Y Cheung
  • Simone Wanderoy
  • Yang Xuan
  • Konstantinos Meletis
  • Jorge Ruas
  • Channabasavaiah B Gurumurthy
  • Kiehn, Ole
  • Saida Hadjab
  • François Lallemend

Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.

Original languageEnglish
Article number1026
JournalNature Communications
Issue number1
Number of pages13
Publication statusPublished - 2021

    Research areas

  • Animals, Calbindin 1/genetics, Calcium-Binding Proteins/genetics, Co-Repressor Proteins/genetics, Core Binding Factor Alpha 2 Subunit/genetics, Core Binding Factor Alpha 3 Subunit/genetics, Feedback, Sensory/physiology, Ganglia, Spinal/cytology, Gene Expression, LIM Domain Proteins/genetics, Lectins, C-Type/genetics, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Neurons/classification, Nerve Tissue Proteins/genetics, Physical Conditioning, Animal, Proprioception/physiology, Sensory Receptor Cells/classification, Single-Cell Analysis, Spinal Cord/cytology

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