Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. / Wu, Haohao; Petitpré, Charles; Fontanet, Paula; Sharma, Anil; Bellardita, Carmelo; Quadros, Rolen M; Jannig, Paulo R; Wang, Yiqiao; Heimel, J Alexander; Cheung, Kylie K Y; Wanderoy, Simone; Xuan, Yang; Meletis, Konstantinos; Ruas, Jorge; Gurumurthy, Channabasavaiah B; Kiehn, Ole; Hadjab, Saida; Lallemend, François.

In: Nature Communications, Vol. 12, No. 1, 1026, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wu, H, Petitpré, C, Fontanet, P, Sharma, A, Bellardita, C, Quadros, RM, Jannig, PR, Wang, Y, Heimel, JA, Cheung, KKY, Wanderoy, S, Xuan, Y, Meletis, K, Ruas, J, Gurumurthy, CB, Kiehn, O, Hadjab, S & Lallemend, F 2021, 'Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice', Nature Communications, vol. 12, no. 1, 1026. https://doi.org/10.1038/s41467-021-21173-9

APA

Wu, H., Petitpré, C., Fontanet, P., Sharma, A., Bellardita, C., Quadros, R. M., Jannig, P. R., Wang, Y., Heimel, J. A., Cheung, K. K. Y., Wanderoy, S., Xuan, Y., Meletis, K., Ruas, J., Gurumurthy, C. B., Kiehn, O., Hadjab, S., & Lallemend, F. (2021). Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. Nature Communications, 12(1), [1026]. https://doi.org/10.1038/s41467-021-21173-9

Vancouver

Wu H, Petitpré C, Fontanet P, Sharma A, Bellardita C, Quadros RM et al. Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. Nature Communications. 2021;12(1). 1026. https://doi.org/10.1038/s41467-021-21173-9

Author

Wu, Haohao ; Petitpré, Charles ; Fontanet, Paula ; Sharma, Anil ; Bellardita, Carmelo ; Quadros, Rolen M ; Jannig, Paulo R ; Wang, Yiqiao ; Heimel, J Alexander ; Cheung, Kylie K Y ; Wanderoy, Simone ; Xuan, Yang ; Meletis, Konstantinos ; Ruas, Jorge ; Gurumurthy, Channabasavaiah B ; Kiehn, Ole ; Hadjab, Saida ; Lallemend, François. / Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. In: Nature Communications. 2021 ; Vol. 12, No. 1.

Bibtex

@article{78729346db384a6a966d5656692960a0,
title = "Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice",
abstract = "Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.",
keywords = "Animals, Calbindin 1/genetics, Calcium-Binding Proteins/genetics, Co-Repressor Proteins/genetics, Core Binding Factor Alpha 2 Subunit/genetics, Core Binding Factor Alpha 3 Subunit/genetics, Feedback, Sensory/physiology, Ganglia, Spinal/cytology, Gene Expression, LIM Domain Proteins/genetics, Lectins, C-Type/genetics, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Neurons/classification, Nerve Tissue Proteins/genetics, Physical Conditioning, Animal, Proprioception/physiology, Sensory Receptor Cells/classification, Single-Cell Analysis, Spinal Cord/cytology",
author = "Haohao Wu and Charles Petitpr{\'e} and Paula Fontanet and Anil Sharma and Carmelo Bellardita and Quadros, {Rolen M} and Jannig, {Paulo R} and Yiqiao Wang and Heimel, {J Alexander} and Cheung, {Kylie K Y} and Simone Wanderoy and Yang Xuan and Konstantinos Meletis and Jorge Ruas and Gurumurthy, {Channabasavaiah B} and Ole Kiehn and Saida Hadjab and Fran{\c c}ois Lallemend",
year = "2021",
doi = "10.1038/s41467-021-21173-9",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

AU - Wu, Haohao

AU - Petitpré, Charles

AU - Fontanet, Paula

AU - Sharma, Anil

AU - Bellardita, Carmelo

AU - Quadros, Rolen M

AU - Jannig, Paulo R

AU - Wang, Yiqiao

AU - Heimel, J Alexander

AU - Cheung, Kylie K Y

AU - Wanderoy, Simone

AU - Xuan, Yang

AU - Meletis, Konstantinos

AU - Ruas, Jorge

AU - Gurumurthy, Channabasavaiah B

AU - Kiehn, Ole

AU - Hadjab, Saida

AU - Lallemend, François

PY - 2021

Y1 - 2021

N2 - Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.

AB - Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.

KW - Animals

KW - Calbindin 1/genetics

KW - Calcium-Binding Proteins/genetics

KW - Co-Repressor Proteins/genetics

KW - Core Binding Factor Alpha 2 Subunit/genetics

KW - Core Binding Factor Alpha 3 Subunit/genetics

KW - Feedback, Sensory/physiology

KW - Ganglia, Spinal/cytology

KW - Gene Expression

KW - LIM Domain Proteins/genetics

KW - Lectins, C-Type/genetics

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Motor Neurons/classification

KW - Nerve Tissue Proteins/genetics

KW - Physical Conditioning, Animal

KW - Proprioception/physiology

KW - Sensory Receptor Cells/classification

KW - Single-Cell Analysis

KW - Spinal Cord/cytology

U2 - 10.1038/s41467-021-21173-9

DO - 10.1038/s41467-021-21173-9

M3 - Journal article

C2 - 33589589

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1026

ER -

ID: 259454694