Søren Gøgsig Faarup Rasmussen
Associate Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
- 1999
- Published
Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI
Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
The effect of pH on ß2 adrenoceptor function
Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter
Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding G-protein coupled receptors and their role in the CNS
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- 2003
- Published
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy
Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Purification and fluorescent labeling of the human serotonin transporter
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
Whorton, M. R., Bokoch, M. P., Rasmussen, Søren Gøgsig Faarup, Huang, B., Zare, R. N., Kobilka, B. & Sunahara, R. K., 1 May 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7682-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A monoclonal antibody for G protein-coupled receptor crystallography
Day, P. W., Rasmussen, Søren Gøgsig Faarup, Parnot, C., Fung, J. J., Masood, A., Kobilka, T. S., Yao, X., Choi, H., Weis, W. I., Rohrer, D. K. & Kobilka, B. K., Nov 2007, In: Nature Methods. 4, 11, p. 927-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor
Rasmussen, Søren Gøgsig Faarup, Choi, H., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., 15 Nov 2007, In: Nature. 450, 7168, p. 383-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Yao, X., Weis, W. I., Stevens, R. C. & Kobilka, B. K., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1266-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1258-65 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
Richter, W., Day, P., Agrawal, R., Bruss, M. D., Granier, S., Wang, Y. L., Rasmussen, Søren Gøgsig Faarup, Horner, K., Wang, P., Lei, T., Patterson, A. J., Kobilka, B. & Conti, M., 23 Jan 2008, In: E M B O Journal. 27, 2, p. 384-93 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, Søren Gøgsig Faarup & Kobilka, B. K., 21 May 2009, In: Nature. 459, 7245, p. 356-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
Yao, X. J., Vélez Ruiz, G., Whorton, M. R., Rasmussen, Søren Gøgsig Faarup, DeVree, B. T., Deupi, X., Sunahara, R. K. & Kobilka, B., 9 Jun 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9501-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Bokoch, M. P., Zou, Y., Rasmussen, Søren Gøgsig Faarup, Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., 7 Jan 2010, In: Nature. 463, 7277, p. 108-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tandem Facial Amphiphiles for Membrane Protein Stabilization
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Structure and function of an irreversible agonist-β(2) adrenoceptor complex
Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, Søren Gøgsig Faarup, Choi, H., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K., 13 Jan 2011, In: Nature. 469, 7329, p. 236-40 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor
Rasmussen, Søren Gøgsig Faarup, Choi, H., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., 13 Jan 2011, In: Nature. 469, 7329, p. 175-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 7932
Most downloads
-
182
downloads
Ligand modulation of sidechain dynamics in a wild-type human GPCR
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
156
downloads
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
115
downloads
Substrate-induced conformational dynamics of the dopamine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
Published