Lindy Barrett
Senior Group Leader, Broad Institute of MIT and Harvard
“Leveraging iPSC models to study neural development and disease
From https://www.broadinstitute.org/barrett-lab:
We are particularly interested in how epigenetic re-wiring contributes to disease phenotypes, the factors which drive interindividual variation of phenotypes, and whether there are specific molecular or functional points of convergence across disease spectrums. To this end, we use human iPSC models to dissect mechanisms relevant for early human development. Our long-term goal is to leverage molecular and cellular insights to better understand brain development and dysfunction, and to ultimately employ these insights to improve human health.