Working memory features are embedded in hippocampal place fields

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Working memory features are embedded in hippocampal place fields. / Varga, Viktor; Petersen, Peter; Zutshi, Ipshita; Huszar, Roman; Zhang, Yiyao; Buzsáki, György.

In: Cell Reports, Vol. 43, No. 3, 113807, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Varga, V, Petersen, P, Zutshi, I, Huszar, R, Zhang, Y & Buzsáki, G 2024, 'Working memory features are embedded in hippocampal place fields', Cell Reports, vol. 43, no. 3, 113807. https://doi.org/10.1016/j.celrep.2024.113807

APA

Varga, V., Petersen, P., Zutshi, I., Huszar, R., Zhang, Y., & Buzsáki, G. (2024). Working memory features are embedded in hippocampal place fields. Cell Reports, 43(3), [113807]. https://doi.org/10.1016/j.celrep.2024.113807

Vancouver

Varga V, Petersen P, Zutshi I, Huszar R, Zhang Y, Buzsáki G. Working memory features are embedded in hippocampal place fields. Cell Reports. 2024;43(3). 113807. https://doi.org/10.1016/j.celrep.2024.113807

Author

Varga, Viktor ; Petersen, Peter ; Zutshi, Ipshita ; Huszar, Roman ; Zhang, Yiyao ; Buzsáki, György. / Working memory features are embedded in hippocampal place fields. In: Cell Reports. 2024 ; Vol. 43, No. 3.

Bibtex

@article{5ccd5807c4ff4c179e8e5fd6caf58f3a,
title = "Working memory features are embedded in hippocampal place fields",
abstract = "Hippocampal principal neurons display both spatial tuning properties and memory features. Whether this distinction corresponds to separate neuron types or a context-dependent continuum has been debated. We report here that the task-context (“splitter”) feature is highly variable along both trial and spatial position axes. Neurons acquire or lose splitter features across trials even when place field features remain unaltered. Multiple place fields of the same neuron can individually encode both past or future run trajectories, implying that splitter fields are under the control of assembly activity. Place fields can be differentiated into subfields by the behavioral choice of the animal, and splitting within subfields evolves across trials. Interneurons also differentiate choices by integrating inputs from pyramidal cells. Finally, bilateral optogenetic inactivation of the medial entorhinal cortex reversibly decreases the fraction of splitter fields. Our findings suggest that place or splitter features are different manifestations of the same hippocampal computation.",
keywords = "assembly, context, CP: Neuroscience, hippocampus, medial entorhinal cortex, spatial alternation, splitter, working memory",
author = "Viktor Varga and Peter Petersen and Ipshita Zutshi and Roman Huszar and Yiyao Zhang and Gy{\"o}rgy Buzs{\'a}ki",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
doi = "10.1016/j.celrep.2024.113807",
language = "English",
volume = "43",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Working memory features are embedded in hippocampal place fields

AU - Varga, Viktor

AU - Petersen, Peter

AU - Zutshi, Ipshita

AU - Huszar, Roman

AU - Zhang, Yiyao

AU - Buzsáki, György

N1 - Publisher Copyright: © 2024 The Author(s)

PY - 2024

Y1 - 2024

N2 - Hippocampal principal neurons display both spatial tuning properties and memory features. Whether this distinction corresponds to separate neuron types or a context-dependent continuum has been debated. We report here that the task-context (“splitter”) feature is highly variable along both trial and spatial position axes. Neurons acquire or lose splitter features across trials even when place field features remain unaltered. Multiple place fields of the same neuron can individually encode both past or future run trajectories, implying that splitter fields are under the control of assembly activity. Place fields can be differentiated into subfields by the behavioral choice of the animal, and splitting within subfields evolves across trials. Interneurons also differentiate choices by integrating inputs from pyramidal cells. Finally, bilateral optogenetic inactivation of the medial entorhinal cortex reversibly decreases the fraction of splitter fields. Our findings suggest that place or splitter features are different manifestations of the same hippocampal computation.

AB - Hippocampal principal neurons display both spatial tuning properties and memory features. Whether this distinction corresponds to separate neuron types or a context-dependent continuum has been debated. We report here that the task-context (“splitter”) feature is highly variable along both trial and spatial position axes. Neurons acquire or lose splitter features across trials even when place field features remain unaltered. Multiple place fields of the same neuron can individually encode both past or future run trajectories, implying that splitter fields are under the control of assembly activity. Place fields can be differentiated into subfields by the behavioral choice of the animal, and splitting within subfields evolves across trials. Interneurons also differentiate choices by integrating inputs from pyramidal cells. Finally, bilateral optogenetic inactivation of the medial entorhinal cortex reversibly decreases the fraction of splitter fields. Our findings suggest that place or splitter features are different manifestations of the same hippocampal computation.

KW - assembly

KW - context

KW - CP: Neuroscience

KW - hippocampus

KW - medial entorhinal cortex

KW - spatial alternation

KW - splitter

KW - working memory

U2 - 10.1016/j.celrep.2024.113807

DO - 10.1016/j.celrep.2024.113807

M3 - Journal article

C2 - 38401118

AN - SCOPUS:85185707346

VL - 43

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 3

M1 - 113807

ER -

ID: 384068444