When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits

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When networks walk a fine line : balance of excitation and inhibition in spinal motor circuits. / Berg, Rune W.; Willumsen, Alex; Lindén, Henrik.

In: Current Opinion in Physiology, Vol. 8, 2019, p. 76-83.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Berg, RW, Willumsen, A & Lindén, H 2019, 'When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits', Current Opinion in Physiology, vol. 8, pp. 76-83. https://doi.org/10.1016/j.cophys.2019.01.006

APA

Berg, R. W., Willumsen, A., & Lindén, H. (2019). When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits. Current Opinion in Physiology, 8, 76-83. https://doi.org/10.1016/j.cophys.2019.01.006

Vancouver

Berg RW, Willumsen A, Lindén H. When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits. Current Opinion in Physiology. 2019;8:76-83. https://doi.org/10.1016/j.cophys.2019.01.006

Author

Berg, Rune W. ; Willumsen, Alex ; Lindén, Henrik. / When networks walk a fine line : balance of excitation and inhibition in spinal motor circuits. In: Current Opinion in Physiology. 2019 ; Vol. 8. pp. 76-83.

Bibtex

@article{9410ab7e87834e9d95ca15459b7cc1d2,
title = "When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits",
abstract = "Investigations on spinal motor circuits have primarily been related to direct connections to motoneurons and supraspinal input, while the motor pattern generation circuit itself has remained elusive. In the classical half-center model (HCM), motor patterns are generated by feedforward excitation with reciprocal inhibition. However, experiments over the last decade have indicated that inhibition, besides providing reciprocal coordination, may serve additional roles similar to that seen in the brain. Such organization relies on recurrent inhibition to give stability of the spiking activity manifested by simultaneous increases in excitation and inhibition within the network, that is, a {\textquoteleft}balanced network{\textquoteright}. Here we discuss the theoretical concepts and experimental data for and against this architecture in motor circuits, and suggest how it can be integrated in the conventional HCM.",
author = "Berg, {Rune W.} and Alex Willumsen and Henrik Lind{\'e}n",
year = "2019",
doi = "10.1016/j.cophys.2019.01.006",
language = "English",
volume = "8",
pages = "76--83",
journal = "Current Opinion in Physiology",
issn = "2468-8681",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - When networks walk a fine line

T2 - balance of excitation and inhibition in spinal motor circuits

AU - Berg, Rune W.

AU - Willumsen, Alex

AU - Lindén, Henrik

PY - 2019

Y1 - 2019

N2 - Investigations on spinal motor circuits have primarily been related to direct connections to motoneurons and supraspinal input, while the motor pattern generation circuit itself has remained elusive. In the classical half-center model (HCM), motor patterns are generated by feedforward excitation with reciprocal inhibition. However, experiments over the last decade have indicated that inhibition, besides providing reciprocal coordination, may serve additional roles similar to that seen in the brain. Such organization relies on recurrent inhibition to give stability of the spiking activity manifested by simultaneous increases in excitation and inhibition within the network, that is, a ‘balanced network’. Here we discuss the theoretical concepts and experimental data for and against this architecture in motor circuits, and suggest how it can be integrated in the conventional HCM.

AB - Investigations on spinal motor circuits have primarily been related to direct connections to motoneurons and supraspinal input, while the motor pattern generation circuit itself has remained elusive. In the classical half-center model (HCM), motor patterns are generated by feedforward excitation with reciprocal inhibition. However, experiments over the last decade have indicated that inhibition, besides providing reciprocal coordination, may serve additional roles similar to that seen in the brain. Such organization relies on recurrent inhibition to give stability of the spiking activity manifested by simultaneous increases in excitation and inhibition within the network, that is, a ‘balanced network’. Here we discuss the theoretical concepts and experimental data for and against this architecture in motor circuits, and suggest how it can be integrated in the conventional HCM.

U2 - 10.1016/j.cophys.2019.01.006

DO - 10.1016/j.cophys.2019.01.006

M3 - Review

AN - SCOPUS:85061791043

VL - 8

SP - 76

EP - 83

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

SN - 2468-8681

ER -

ID: 221263918