What are the gray and white matter volumes of the human spinal cord?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

What are the gray and white matter volumes of the human spinal cord? / Henmar, Simon; Simonsen, Erik B.; Berg, Rune W.

In: Journal of Neurophysiology, Vol. 124, No. 6, 11.12.2020, p. 1792-1797.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henmar, S, Simonsen, EB & Berg, RW 2020, 'What are the gray and white matter volumes of the human spinal cord?', Journal of Neurophysiology, vol. 124, no. 6, pp. 1792-1797. https://doi.org/10.1152/jn.00413.2020

APA

Henmar, S., Simonsen, E. B., & Berg, R. W. (2020). What are the gray and white matter volumes of the human spinal cord? Journal of Neurophysiology, 124(6), 1792-1797. https://doi.org/10.1152/jn.00413.2020

Vancouver

Henmar S, Simonsen EB, Berg RW. What are the gray and white matter volumes of the human spinal cord? Journal of Neurophysiology. 2020 Dec 11;124(6):1792-1797. https://doi.org/10.1152/jn.00413.2020

Author

Henmar, Simon ; Simonsen, Erik B. ; Berg, Rune W. / What are the gray and white matter volumes of the human spinal cord?. In: Journal of Neurophysiology. 2020 ; Vol. 124, No. 6. pp. 1792-1797.

Bibtex

@article{3e83d05db51d4b34a0ac82eaad1c3424,
title = "What are the gray and white matter volumes of the human spinal cord?",
abstract = "The gray matter of the spinal cord is the seat of somata of various types of neurons devoted to the sensory and motor activities of the limbs and trunk as well as a part of the autonomic nervous system. The volume of the spinal gray matter is an indicator of the local neuronal processing, and this can decrease due to atrophy associated with degenerative diseases and injury. Nevertheless, the absolute volume of the human spinal cord has rarely been reported, if ever. Here, we use high-resolution magnetic resonance imaging, with a cross-sectional resolution of 50 × 50 μm and a voxel size of 0.0005 mm3 to estimate the total gray and white matter volume of a post mortem human female spinal cord. Segregation of gray and white matter was accomplished using deep learning image segmentation. Furthermore, we include data from a male spinal cord of a previously published study. The gray and white matter volumes were found to be 2.87 and 11.33 mL, respectively, for the female and 3.55 and 19.33 mL, respectively, for the male. The gray and white matter profiles along the vertebral axis were found to be strikingly similar, and the volumes of the cervical, thoracic, and lumbosacral sections were almost equal.",
keywords = "Gray matter, Human, MRI, Spinal cord, Substantia grisea, Volume",
author = "Simon Henmar and Simonsen, {Erik B.} and Berg, {Rune W.}",
year = "2020",
month = dec,
day = "11",
doi = "10.1152/jn.00413.2020",
language = "English",
volume = "124",
pages = "1792--1797",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - What are the gray and white matter volumes of the human spinal cord?

AU - Henmar, Simon

AU - Simonsen, Erik B.

AU - Berg, Rune W.

PY - 2020/12/11

Y1 - 2020/12/11

N2 - The gray matter of the spinal cord is the seat of somata of various types of neurons devoted to the sensory and motor activities of the limbs and trunk as well as a part of the autonomic nervous system. The volume of the spinal gray matter is an indicator of the local neuronal processing, and this can decrease due to atrophy associated with degenerative diseases and injury. Nevertheless, the absolute volume of the human spinal cord has rarely been reported, if ever. Here, we use high-resolution magnetic resonance imaging, with a cross-sectional resolution of 50 × 50 μm and a voxel size of 0.0005 mm3 to estimate the total gray and white matter volume of a post mortem human female spinal cord. Segregation of gray and white matter was accomplished using deep learning image segmentation. Furthermore, we include data from a male spinal cord of a previously published study. The gray and white matter volumes were found to be 2.87 and 11.33 mL, respectively, for the female and 3.55 and 19.33 mL, respectively, for the male. The gray and white matter profiles along the vertebral axis were found to be strikingly similar, and the volumes of the cervical, thoracic, and lumbosacral sections were almost equal.

AB - The gray matter of the spinal cord is the seat of somata of various types of neurons devoted to the sensory and motor activities of the limbs and trunk as well as a part of the autonomic nervous system. The volume of the spinal gray matter is an indicator of the local neuronal processing, and this can decrease due to atrophy associated with degenerative diseases and injury. Nevertheless, the absolute volume of the human spinal cord has rarely been reported, if ever. Here, we use high-resolution magnetic resonance imaging, with a cross-sectional resolution of 50 × 50 μm and a voxel size of 0.0005 mm3 to estimate the total gray and white matter volume of a post mortem human female spinal cord. Segregation of gray and white matter was accomplished using deep learning image segmentation. Furthermore, we include data from a male spinal cord of a previously published study. The gray and white matter volumes were found to be 2.87 and 11.33 mL, respectively, for the female and 3.55 and 19.33 mL, respectively, for the male. The gray and white matter profiles along the vertebral axis were found to be strikingly similar, and the volumes of the cervical, thoracic, and lumbosacral sections were almost equal.

KW - Gray matter

KW - Human

KW - MRI

KW - Spinal cord

KW - Substantia grisea

KW - Volume

U2 - 10.1152/jn.00413.2020

DO - 10.1152/jn.00413.2020

M3 - Journal article

C2 - 33085549

AN - SCOPUS:85097749985

VL - 124

SP - 1792

EP - 1797

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 6

ER -

ID: 258441670