Voltage fluctuations in neurons: signal or noise?

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Voltage fluctuations in neurons: signal or noise? / Yarom, Yosef; Hounsgaard, Jorn.

In: Physiological Reviews, Vol. 91, No. 3, 01.07.2011, p. 917-29.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yarom, Y & Hounsgaard, J 2011, 'Voltage fluctuations in neurons: signal or noise?', Physiological Reviews, vol. 91, no. 3, pp. 917-29. https://doi.org/10.1152/physrev.00019.2010

APA

Yarom, Y., & Hounsgaard, J. (2011). Voltage fluctuations in neurons: signal or noise? Physiological Reviews, 91(3), 917-29. https://doi.org/10.1152/physrev.00019.2010

Vancouver

Yarom Y, Hounsgaard J. Voltage fluctuations in neurons: signal or noise? Physiological Reviews. 2011 Jul 1;91(3):917-29. https://doi.org/10.1152/physrev.00019.2010

Author

Yarom, Yosef ; Hounsgaard, Jorn. / Voltage fluctuations in neurons: signal or noise?. In: Physiological Reviews. 2011 ; Vol. 91, No. 3. pp. 917-29.

Bibtex

@article{a422ba9af91a4392ad09acc3ab5ca1be,
title = "Voltage fluctuations in neurons: signal or noise?",
abstract = "Noise and variability are fundamental companions to ion channels and synapses and thus inescapable elements of brain function. The overriding unresolved issue is to what extent noise distorts and limits signaling on one hand and at the same time constitutes a crucial and fundamental enrichment that allows and facilitates complex adaptive behavior in an unpredictable world. Here we review the growing experimental evidence that functional network activity is associated with intense fluctuations in membrane potential and spike timing. We trace origins and consequences of noise and variability. Finally, we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues for future studies.",
author = "Yosef Yarom and Jorn Hounsgaard",
year = "2011",
month = jul,
day = "1",
doi = "10.1152/physrev.00019.2010",
language = "English",
volume = "91",
pages = "917--29",
journal = "Physiological Reviews",
issn = "0031-9333",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Voltage fluctuations in neurons: signal or noise?

AU - Yarom, Yosef

AU - Hounsgaard, Jorn

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Noise and variability are fundamental companions to ion channels and synapses and thus inescapable elements of brain function. The overriding unresolved issue is to what extent noise distorts and limits signaling on one hand and at the same time constitutes a crucial and fundamental enrichment that allows and facilitates complex adaptive behavior in an unpredictable world. Here we review the growing experimental evidence that functional network activity is associated with intense fluctuations in membrane potential and spike timing. We trace origins and consequences of noise and variability. Finally, we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues for future studies.

AB - Noise and variability are fundamental companions to ion channels and synapses and thus inescapable elements of brain function. The overriding unresolved issue is to what extent noise distorts and limits signaling on one hand and at the same time constitutes a crucial and fundamental enrichment that allows and facilitates complex adaptive behavior in an unpredictable world. Here we review the growing experimental evidence that functional network activity is associated with intense fluctuations in membrane potential and spike timing. We trace origins and consequences of noise and variability. Finally, we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues for future studies.

U2 - 10.1152/physrev.00019.2010

DO - 10.1152/physrev.00019.2010

M3 - Journal article

C2 - 21742791

VL - 91

SP - 917

EP - 929

JO - Physiological Reviews

JF - Physiological Reviews

SN - 0031-9333

IS - 3

ER -

ID: 33757074