Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions

Research output: Contribution to journal › Journal article › Research › peer-review

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Using stable isotope tracing to unravel the metabolic components of neurodegeneration : Focus on neuron-glia metabolic interactions. / Westi, Emil W.; Andersen, Jens V.; Aldana, Blanca I.

In: Neurobiology of Disease, Vol. 182, 106145, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Westi, EW, Andersen, JV & Aldana, BI 2023, 'Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions', Neurobiology of Disease, vol. 182, 106145. https://doi.org/10.1016/j.nbd.2023.106145

APA

Westi, E. W., Andersen, J. V., & Aldana, B. I. (2023). Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions. Neurobiology of Disease, 182, [106145]. https://doi.org/10.1016/j.nbd.2023.106145

Vancouver

Westi EW, Andersen JV, Aldana BI. Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions. Neurobiology of Disease. 2023;182. 106145. https://doi.org/10.1016/j.nbd.2023.106145

Author

Westi, Emil W. ; Andersen, Jens V. ; Aldana, Blanca I. / Using stable isotope tracing to unravel the metabolic components of neurodegeneration : Focus on neuron-glia metabolic interactions. In: Neurobiology of Disease. 2023 ; Vol. 182.

Bibtex

@article{530e8a5de5a94847b3774f0b5c1ff849,
title = "Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions",
abstract = "Disrupted brain metabolism is a critical component of several neurodegenerative diseases. Energy metabolism of both neurons and astrocytes is closely connected to neurotransmitter recycling via the glutamate/GABA-glutamine cycle. Neurons and astrocytes hereby work in close metabolic collaboration which is essential to sustain neurotransmission. Elucidating the mechanistic involvement of altered brain metabolism in disease progression has been aided by the advance of techniques to monitor cellular metabolism, in particular by mapping metabolism of substrates containing stable isotopes, a technique known as isotope tracing. Here we review key aspects of isotope tracing including advantages, drawbacks and applications to different cerebral preparations. In addition, we narrate how isotope tracing has facilitated the discovery of central metabolic features in neurodegeneration with a focus on the metabolic cooperation between neurons and astrocytes.",
keywords = "Alzheimer's disease, Amyotrophic lateral sclerosis, Astrocytes, Brain energy metabolism, Huntington's disease, Mass spectrometry, Neurodegenerative disorders, Parkinson's disease",
author = "Westi, {Emil W.} and Andersen, {Jens V.} and Aldana, {Blanca I.}",
note = "Funding Information: The Lundbeck Foundation (grant reference R389-2021-1596 , PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW . The SSADH Association and the H{\o}rslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the H{\o}rslev Foundation are acknowledged for support to BIA. Funding Information: The Lundbeck Foundation (grant reference R389-2021-1596, PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW. The SSADH Association and the H{\o}rslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the H{\o}rslev Foundation are acknowledged for support to BIA. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.nbd.2023.106145",
language = "English",
volume = "182",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Using stable isotope tracing to unravel the metabolic components of neurodegeneration

T2 - Focus on neuron-glia metabolic interactions

AU - Westi, Emil W.

AU - Andersen, Jens V.

AU - Aldana, Blanca I.

N1 - Funding Information: The Lundbeck Foundation (grant reference R389-2021-1596 , PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW . The SSADH Association and the Hørslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the Hørslev Foundation are acknowledged for support to BIA. Funding Information: The Lundbeck Foundation (grant reference R389-2021-1596, PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW. The SSADH Association and the Hørslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the Hørslev Foundation are acknowledged for support to BIA. Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Disrupted brain metabolism is a critical component of several neurodegenerative diseases. Energy metabolism of both neurons and astrocytes is closely connected to neurotransmitter recycling via the glutamate/GABA-glutamine cycle. Neurons and astrocytes hereby work in close metabolic collaboration which is essential to sustain neurotransmission. Elucidating the mechanistic involvement of altered brain metabolism in disease progression has been aided by the advance of techniques to monitor cellular metabolism, in particular by mapping metabolism of substrates containing stable isotopes, a technique known as isotope tracing. Here we review key aspects of isotope tracing including advantages, drawbacks and applications to different cerebral preparations. In addition, we narrate how isotope tracing has facilitated the discovery of central metabolic features in neurodegeneration with a focus on the metabolic cooperation between neurons and astrocytes.

AB - Disrupted brain metabolism is a critical component of several neurodegenerative diseases. Energy metabolism of both neurons and astrocytes is closely connected to neurotransmitter recycling via the glutamate/GABA-glutamine cycle. Neurons and astrocytes hereby work in close metabolic collaboration which is essential to sustain neurotransmission. Elucidating the mechanistic involvement of altered brain metabolism in disease progression has been aided by the advance of techniques to monitor cellular metabolism, in particular by mapping metabolism of substrates containing stable isotopes, a technique known as isotope tracing. Here we review key aspects of isotope tracing including advantages, drawbacks and applications to different cerebral preparations. In addition, we narrate how isotope tracing has facilitated the discovery of central metabolic features in neurodegeneration with a focus on the metabolic cooperation between neurons and astrocytes.

KW - Alzheimer's disease

KW - Amyotrophic lateral sclerosis

KW - Astrocytes

KW - Brain energy metabolism

KW - Huntington's disease

KW - Mass spectrometry

KW - Neurodegenerative disorders

KW - Parkinson's disease

U2 - 10.1016/j.nbd.2023.106145

DO - 10.1016/j.nbd.2023.106145

M3 - Journal article

C2 - 37150307

AN - SCOPUS:85157973592

VL - 182

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

M1 - 106145

ER -

ID: 347400059