Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain

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Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. / Landau, Anne M.; Noer, Ove; Alstrup, Aage Kristian Olsen; Audrain, Hélène; Wegener, Gregers; Gjedde, Albert; Doudet, Doris J.; Winterdahl, Michael.

In: Molecular Imaging and Biology, Vol. 22, No. 4, 01.08.2020, p. 797-804.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Landau, AM, Noer, O, Alstrup, AKO, Audrain, H, Wegener, G, Gjedde, A, Doudet, DJ & Winterdahl, M 2020, 'Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain', Molecular Imaging and Biology, vol. 22, no. 4, pp. 797-804. https://doi.org/10.1007/s11307-020-01476-x

APA

Landau, A. M., Noer, O., Alstrup, A. K. O., Audrain, H., Wegener, G., Gjedde, A., Doudet, D. J., & Winterdahl, M. (2020). Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. Molecular Imaging and Biology, 22(4), 797-804. https://doi.org/10.1007/s11307-020-01476-x

Vancouver

Landau AM, Noer O, Alstrup AKO, Audrain H, Wegener G, Gjedde A et al. Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. Molecular Imaging and Biology. 2020 Aug 1;22(4):797-804. https://doi.org/10.1007/s11307-020-01476-x

Author

Landau, Anne M. ; Noer, Ove ; Alstrup, Aage Kristian Olsen ; Audrain, Hélène ; Wegener, Gregers ; Gjedde, Albert ; Doudet, Doris J. ; Winterdahl, Michael. / Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. In: Molecular Imaging and Biology. 2020 ; Vol. 22, No. 4. pp. 797-804.

Bibtex

@article{987ad122f8174c1da79f8d605bc04c99,
title = "Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain",
abstract = "Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT2A receptors. Procedures: Isoflurane- and propofol-anesthetised G{\"o}ttingen minipigs were imaged with [11C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping. Results: The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Conclusions: Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.",
keywords = "Animal, G{\"o}ttingen minipig, Isoflurane, PET, Propofol, Serotonin, Swine, [C]MDL100,907",
author = "Landau, {Anne M.} and Ove Noer and Alstrup, {Aage Kristian Olsen} and H{\'e}l{\`e}ne Audrain and Gregers Wegener and Albert Gjedde and Doudet, {Doris J.} and Michael Winterdahl",
note = "Publisher Copyright: {\textcopyright} 2020, World Molecular Imaging Society.",
year = "2020",
month = aug,
day = "1",
doi = "10.1007/s11307-020-01476-x",
language = "English",
volume = "22",
pages = "797--804",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain

AU - Landau, Anne M.

AU - Noer, Ove

AU - Alstrup, Aage Kristian Olsen

AU - Audrain, Hélène

AU - Wegener, Gregers

AU - Gjedde, Albert

AU - Doudet, Doris J.

AU - Winterdahl, Michael

N1 - Publisher Copyright: © 2020, World Molecular Imaging Society.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT2A receptors. Procedures: Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [11C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping. Results: The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Conclusions: Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.

AB - Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT2A receptors. Procedures: Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [11C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping. Results: The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Conclusions: Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.

KW - Animal

KW - Göttingen minipig

KW - Isoflurane

KW - PET

KW - Propofol

KW - Serotonin

KW - Swine

KW - [C]MDL100,907

U2 - 10.1007/s11307-020-01476-x

DO - 10.1007/s11307-020-01476-x

M3 - Journal article

C2 - 31993926

AN - SCOPUS:85078916576

VL - 22

SP - 797

EP - 804

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 4

ER -

ID: 286485318