TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

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TSPO Imaging in Glioblastoma Multiforme : A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging. / Jensen, Per; Feng, Ling; Law, Ian; Svarer, Claus; Knudsen, Gitte M; Mikkelsen, Jens D; de Nijs, Robin; Larsen, Vibeke A; Dyssegaard, Agnete; Thomsen, Gerda; Fischer, Walter; Guilloteau, Denis; Pinborg, Lars H.

In: Journal of Nuclear Medicine, Vol. 56, No. 9, 09.2015, p. 1386-90.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Jensen, P, Feng, L, Law, I, Svarer, C, Knudsen, GM, Mikkelsen, JD, de Nijs, R, Larsen, VA, Dyssegaard, A, Thomsen, G, Fischer, W, Guilloteau, D & Pinborg, LH 2015, 'TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging', Journal of Nuclear Medicine, vol. 56, no. 9, pp. 1386-90. https://doi.org/10.2967/jnumed.115.158998

APA

Jensen, P., Feng, L., Law, I., Svarer, C., Knudsen, G. M., Mikkelsen, J. D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D., & Pinborg, L. H. (2015). TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging. Journal of Nuclear Medicine, 56(9), 1386-90. https://doi.org/10.2967/jnumed.115.158998

Vancouver

Jensen P, Feng L, Law I, Svarer C, Knudsen GM, Mikkelsen JD et al. TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging. Journal of Nuclear Medicine. 2015 Sep;56(9):1386-90. https://doi.org/10.2967/jnumed.115.158998

Author

Jensen, Per ; Feng, Ling ; Law, Ian ; Svarer, Claus ; Knudsen, Gitte M ; Mikkelsen, Jens D ; de Nijs, Robin ; Larsen, Vibeke A ; Dyssegaard, Agnete ; Thomsen, Gerda ; Fischer, Walter ; Guilloteau, Denis ; Pinborg, Lars H. / TSPO Imaging in Glioblastoma Multiforme : A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging. In: Journal of Nuclear Medicine. 2015 ; Vol. 56, No. 9. pp. 1386-90.

Bibtex

@article{022c26a2e5bb4a60b9efd99e913f5132,
title = "TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging",
abstract = "UNLABELLED: Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT ((123)I-CLINDE) and amino acid transport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine PET ((18)F-FET) and investigate whether (123)I-CLINDE is superior to (18)F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up.METHODS: Three patients with World Health Organization grade IV GBM were scanned with (123)I-CLINDE SPECT, (18)F-FET PET, and gadolinium-enhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans.RESULTS: The percentage overlap between volumes of interest (VOIs) of increased (18)F-FET uptake and (123)I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for (18)F-FET (79%-93%) than (123)I-CLINDE (15%-30%). In contrast, VOIs of increased contrast enhancement at follow-up compared with baseline overlapped to a greater extent with baseline (123)I-CLINDE VOIs than (18)F-FET VOIs (21% vs. 8% and 72% vs. 55%).CONCLUSION: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at follow-up and may be less susceptible to changes in blood-brain barrier permeability than (18)F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.",
keywords = "Aged, Bicyclo Compounds, Heterocyclic, Biomarkers, Tumor, Brain Neoplasms, Female, Fluorodeoxyglucose F18, Gadolinium, Glioblastoma, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Molecular Imaging, Radiopharmaceuticals, Receptors, GABA, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution, Tomography, Emission-Computed, Tyrosine",
author = "Per Jensen and Ling Feng and Ian Law and Claus Svarer and Knudsen, {Gitte M} and Mikkelsen, {Jens D} and {de Nijs}, Robin and Larsen, {Vibeke A} and Agnete Dyssegaard and Gerda Thomsen and Walter Fischer and Denis Guilloteau and Pinborg, {Lars H}",
note = "{\textcopyright} 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
year = "2015",
month = sep,
doi = "10.2967/jnumed.115.158998",
language = "English",
volume = "56",
pages = "1386--90",
journal = "The Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "9",

}

RIS

TY - JOUR

T1 - TSPO Imaging in Glioblastoma Multiforme

T2 - A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

AU - Jensen, Per

AU - Feng, Ling

AU - Law, Ian

AU - Svarer, Claus

AU - Knudsen, Gitte M

AU - Mikkelsen, Jens D

AU - de Nijs, Robin

AU - Larsen, Vibeke A

AU - Dyssegaard, Agnete

AU - Thomsen, Gerda

AU - Fischer, Walter

AU - Guilloteau, Denis

AU - Pinborg, Lars H

N1 - © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PY - 2015/9

Y1 - 2015/9

N2 - UNLABELLED: Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT ((123)I-CLINDE) and amino acid transport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine PET ((18)F-FET) and investigate whether (123)I-CLINDE is superior to (18)F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up.METHODS: Three patients with World Health Organization grade IV GBM were scanned with (123)I-CLINDE SPECT, (18)F-FET PET, and gadolinium-enhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans.RESULTS: The percentage overlap between volumes of interest (VOIs) of increased (18)F-FET uptake and (123)I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for (18)F-FET (79%-93%) than (123)I-CLINDE (15%-30%). In contrast, VOIs of increased contrast enhancement at follow-up compared with baseline overlapped to a greater extent with baseline (123)I-CLINDE VOIs than (18)F-FET VOIs (21% vs. 8% and 72% vs. 55%).CONCLUSION: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at follow-up and may be less susceptible to changes in blood-brain barrier permeability than (18)F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.

AB - UNLABELLED: Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT ((123)I-CLINDE) and amino acid transport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine PET ((18)F-FET) and investigate whether (123)I-CLINDE is superior to (18)F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up.METHODS: Three patients with World Health Organization grade IV GBM were scanned with (123)I-CLINDE SPECT, (18)F-FET PET, and gadolinium-enhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans.RESULTS: The percentage overlap between volumes of interest (VOIs) of increased (18)F-FET uptake and (123)I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for (18)F-FET (79%-93%) than (123)I-CLINDE (15%-30%). In contrast, VOIs of increased contrast enhancement at follow-up compared with baseline overlapped to a greater extent with baseline (123)I-CLINDE VOIs than (18)F-FET VOIs (21% vs. 8% and 72% vs. 55%).CONCLUSION: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at follow-up and may be less susceptible to changes in blood-brain barrier permeability than (18)F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.

KW - Aged

KW - Bicyclo Compounds, Heterocyclic

KW - Biomarkers, Tumor

KW - Brain Neoplasms

KW - Female

KW - Fluorodeoxyglucose F18

KW - Gadolinium

KW - Glioblastoma

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Molecular Imaging

KW - Radiopharmaceuticals

KW - Receptors, GABA

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Tissue Distribution

KW - Tomography, Emission-Computed

KW - Tyrosine

U2 - 10.2967/jnumed.115.158998

DO - 10.2967/jnumed.115.158998

M3 - Comment/debate

C2 - 26182972

VL - 56

SP - 1386

EP - 1390

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 9

ER -

ID: 162647472